Journal
EMBO MOLECULAR MEDICINE
Volume 14, Issue 11, Pages -Publisher
WILEY
DOI: 10.15252/emmm.202013260
Keywords
cannabis; e-cigarettes; environment; iPSC; opioids
Categories
Funding
- Stanford Cardiovascular Institute, Tobacco-Related Disease Research Program (TRDRP) [27IR-0012]
- Steven M. Gootter Foundation [P01 HL152953]
- American Heart Association [20YVNR3500014]
- Stanford Maternal & Child Health Research Institute (MCHRI) Tip Grant
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Induced pluripotent stem cells (iPSCs) are a powerful modeling system to investigate the effects of environmental exposure on the cardiovascular system. They can elucidate the impacts of environmental factors and genetic polymorphisms on cardiovascular diseases.
Induced pluripotent stem cells (iPSCs) are a powerful modeling system for medical discovery and translational research. To date, most studies have focused on the potential for iPSCs for regenerative medicine, drug discovery, and disease modeling. However, iPSCs are also a powerful modeling system to investigate the effects of environmental exposure on the cardiovascular system. With the emergence of e-cigarettes, air pollution, marijuana use, opioids, and microplastics as novel cardiovascular risk factors, iPSCs have the potential for elucidating the effects of these toxins on the body using conventional two-dimensional (2D) arrays and more advanced tissue engineering approaches with organoid and other three-dimensional (3D) models. The effects of these environmental factors may be enhanced by genetic polymorphisms that make some individuals more susceptible to the effects of toxins. iPSC disease modeling may reveal important gene-environment interactions that exacerbate cardiovascular disease and predispose some individuals to adverse outcomes. Thus, iPSCs and gene-editing techniques could play a pivotal role in elucidating the mechanisms of gene-environment interactions and understanding individual variability in susceptibility to environmental effects.
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