Making liver cancer cells go ARGh!

A recent study by Missiaen et al (2022) uncovers hepatocellular carcinoma (HCC) cells to downregulate urea cycle enzymes and rely on the uptake of exogenous arginine and GCN2 kinase-dependent cell-cycle arrest for survival. These results offer new avenues for combinatorial targeting of liver cancer.

Automated summary

A recent study has revealed that hepatocellular carcinoma cells suppress the urea cycle enzymes and depend on the uptake of exogenous arginine and GCN2 kinase-induced cell-cycle arrest for survival. These findings present new possibilities for combination therapy in liver cancer.