4.7 Article

Cadmium exposure causes mitochondrial fission and fusion disorder in the pig hypothalamus via the PI3K/AKT pathway

Related references

Note: Only part of the references are listed.
Article Environmental Sciences

The antagonistic effect of selenium on lead-induced apoptosis and necroptosis via P38/JNK/ERK pathway in chicken kidney

Zhiruo Miao et al.

Summary: Lead and selenium interact in chicken kidneys, and selenium can regulate the signaling pathway activated by lead, reducing the damage to chicken kidney cells.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Article Environmental Sciences

Glyphosate damages blood-testis barrier via NOX1-triggered oxidative stress in rats: Long-term exposure as a potential risk for male reproductive health

Jing-Bo Liu et al.

Summary: Long-term exposure to GLY adversely affects BTB integrity and disrupts spermatogenesis.

ENVIRONMENT INTERNATIONAL (2022)

Article Fisheries

Exposure to imidacloprid induce oxidative stress, mitochondrial dysfunction, inflammation, apoptosis and mitophagy via NF-kappaB/JNK pathway in grass carp hepatocytes

Zhiruo Miao et al.

Summary: Exposure to IMI caused oxidative stress in grass carp hepatocytes, leading to mitochondrial dysfunction, inflammation, apoptosis, and mitophagy.

FISH & SHELLFISH IMMUNOLOGY (2022)

Article Engineering, Environmental

Cadmium exposure triggers oxidative stress, necroptosis, Th1/Th2 imbalance and promotes inflammation through the TNF-α/NF-ΚB pathway in swine small intestine

Xiaoming Chen et al.

Summary: The study revealed that cadmium induced toxic effects in pig intestines primarily through activating necroptosis and inflammation pathways, resulting in damage. Additionally, cadmium caused an imbalance in Th1/Th2 immunity, exacerbating inflammatory responses.

JOURNAL OF HAZARDOUS MATERIALS (2022)

Article Engineering, Environmental

Chlorpyrifos triggers epithelioma papulosum cyprini cell pyroptosis via miR-124-3p/CAPN1 axis

Zhiying Miao et al.

Summary: CPF exposure induces pyroptosis in EPC cells by regulating the miR-124-3p/CAPN1 axis. Pyroptosis leads to mitochondrial dysfunction and upregulation of inflammatory genes.

JOURNAL OF HAZARDOUS MATERIALS (2022)

Article Marine & Freshwater Biology

Tea polyphenols alleviates acetochlor-induced apoptosis and necroptosis via ROS/MAPK/NF-κB signaling in Ctenopharyngodon idellus kidney cells

Xia Zhao et al.

Summary: The present study demonstrates the effects of acetochlor exposure on fish cells, including oxidative stress, mitochondrial damage, lactate accumulation, and cell death. However, tea polyphenols can alleviate these issues and protect cells from oxidative stress.

AQUATIC TOXICOLOGY (2022)

Article Marine & Freshwater Biology

Eucalyptol relieves imidacloprid-induced autophagy through the miR-451/Cab39/AMPK axis in Ctenopharyngodon idellus kidney cells

Xiaojing Li et al.

Summary: This study examined the effect of IMI exposure on autophagy in fish kidney cells and the potential of eucalyptol to protect against the toxicity of IMI. The results showed that IMI induced autophagy in the cells, while eucalyptol treatment alleviated the autophagy and its associated signals. These findings provide insights into the mechanism of biological threat posed by IMI exposure to fish and the potential application of eucalyptol in aquaculture.

AQUATIC TOXICOLOGY (2022)

Article Biochemistry & Molecular Biology

The protective effect of selenoprotein M on non-alcoholic fatty liver disease: the role of the AMPKα1-MFN2 pathway and Parkin mitophagy

Jingzeng Cai et al.

Summary: This study reveals the role of selenoprotein M (SELENOM) in maintaining mitophagy in high-fat diet-induced non-alcoholic fatty liver disease (NAFLD). SELENOM downregulation aggravates hepatic steatosis, inflammation, and fibrosis, while reducing mitophagy and increasing mitochondrial apoptosis. SELENOM overexpression activates Parkin-mediated mitophagy, reducing mitochondrial apoptosis and removing damaged mitochondria.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Article Fisheries

The endoplasmic reticulum-mitochondrial crosstalk is involved in the mitigation mechanism of eucalyptol on imidacloprid toxicity in Ctenopharyngodon idellus kidney cells

Xiaojing Li et al.

Summary: Imidacloprid, a widely used insecticide in agriculture, poses a threat to aquatic organisms. Eucalyptol, a compound found in plants, has a protective effect against imidacloprid-induced cell damage and dysimmunity by restoring endoplasmic reticulum stress and mitochondrial balance. These findings provide insights into the biological threat posed by imidacloprid exposure to fish and the potential application of eucalyptol in aquaculture.

FISH & SHELLFISH IMMUNOLOGY (2022)

Article Environmental Sciences

Polystyrene microplastics-induced cardiotoxicity in chickens via the ROS-driven NF-?B-NLRP3-GSDMD and AMPK-PGC-1a axes

Yue Zhang et al.

Summary: The study found that microplastics caused severe pathological damage to the hearts of chickens, leading to myocardial pyroptosis, inflammation, and mitochondrial damage. PS-MPs triggered alterations in NF-kappa B-NLRP3-GSDMD and AMPK-PGC-1 alpha pathways via ROS overload, resulting in oxidative stress, myocardial pyroptosis, inflammation, mitochondrial dysfunction, and energy metabolism disorders.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Article Environmental Sciences

Oxidative stress mediated by the TLR4/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice?

Hao Wu et al.

Summary: Microplastics can induce uterine fibrosis in female mice by triggering oxidative stress and activating the Notch and TGF-f3 signaling pathways through the TLR4/NOX2 signaling axis. Inhibition of the TLR4/NOX2 signaling pathway can reduce the expression of fibrotic genes, suggesting it as a potential therapeutic option to alleviate the reproductive toxicity of microplastics.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Article Biochemistry & Molecular Biology

miR-20b suppresses mitochondrial dysfunction-mediated apoptosis to alleviate hyperoxia-induced acute lung injury by directly targeting MFN1 and MFN2

Genhua Mu et al.

Summary: The study revealed that miR-20b plays a crucial role in hyperoxia-induced acute lung injury (HALI) by regulating mitochondrial fusion proteins and mitigating cellular damage and apoptosis. These findings offer new insights into the pathogenesis of HALI.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2021)

Article Environmental Sciences

Typical phthalic acid esters induce apoptosis by regulating the PI3K/Akt/Bcl-2 signaling pathway in rat insulinoma cells

Liping Li et al.

Summary: The combined effect of DEHP and DBP promotes pancreatic beta cell apoptosis through a ROS-mediated PI3K/Akt/Bcl-2 pathway, significantly higher than the effects of each PAE alone. This effect is not currently considered in safety standards and studies, highlighting the need for further research to establish more impactful and safer standards.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Environmental Sciences

Pig lung fibrosis is active in the subacute CdCl2 exposure model and exerts cumulative toxicity through the M1/M2 imbalance

Shi Xu et al.

Summary: The study found that subacute CdCl2 exposure leads to lung tissue fibrosis in pigs, resulting in symptoms such as increased Cd content, down-regulation of miR-20a-3p, imbalance of M1/M2, and decreased LXA4/FPR2 content, activating multiple pathways leading to an increase in fibrosis-related factor expression.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Pharmacology & Pharmacy

Cadmium induces apoptosis of pig lymph nodes by regulating the PI3K/AKT/HIF-1α pathway

Lu Yiming et al.

Summary: The study revealed that Cd exposure resulted in increased Cd deposition, elevated apoptosis rates, and oxidative stress in pig lymph nodes. Additionally, Cd induced mitochondrial dynamics disorder, altered expression levels of apoptosis-related genes, and downregulated the expression of PI3K/AKT/HIF-1 alpha signaling pathway in the lymph nodes.

TOXICOLOGY (2021)

Article Food Science & Technology

Chronic oral exposure to cadmium causes liver inflammation by NLRP3 inflammasome activation in pubertal mice

Xusheng Li et al.

Summary: Pubertal mice exposed to low-dose cadmium exhibit liver inflammation and severe injury, including inflammatory hepatocyte infiltration, increased apoptotic cells, and upregulation of cytokine expression.

FOOD AND CHEMICAL TOXICOLOGY (2021)

Article Environmental Sciences

Cadmium induces the thymus apoptosis of pigs through ROS-dependent PTEN/PI3K/AKT signaling pathway

Yiming Zhang et al.

Summary: Cadmium accumulation in pigs can induce apoptosis in thymus cells and activate oxidative stress pathways, leading to oxidative damage to immune tissues. Additionally, exposure to cadmium can affect antioxidant indices and alter the levels of related genes in the PTEN/PI3K/AKT pathway, ultimately impacting cell survival.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

Review Biochemistry & Molecular Biology

Mitochondrial dynamics in health and disease

Nethmi M. B. Yapa et al.

Summary: Mitochondria in animals form interconnected tubular networks through fission and fusion mechanisms, which are crucial for maintaining cellular and organismal health. Imbalance in mitochondrial dynamics can lead to diseases, including neurodegenerative disorders.

FEBS LETTERS (2021)

Article Pharmacology & Pharmacy

Cadmium disrupts mitochondrial distribution and activates excessive mitochondrial fission by elevating cytosolic calcium independent of MCU-mediated mitochondrial calcium uptake in its neurotoxicity

Ju Tang et al.

Summary: Cadmium exposure slows down the rapid movement of mitochondria in neurons, leading to abnormal distribution and excessive fragmentation of mitochondria, ultimately causing mitochondrial membrane potential loss and neuronal damage. Chelating overloaded cytosolic calcium is a promising strategy to prevent cadmium-induced neurotoxicity.

TOXICOLOGY (2021)

Article Environmental Sciences

Cadmium induces apoptosis of human granulosa cell line KGN via mitochondrial dysfunction-mediated pathways

Guofeng Xu et al.

Summary: Cadmium exposure triggers apoptosis in KGN cells by inducing mitochondrial dysfunction, including excessive ROS production and intracellular Ca2+ overload. Activation of downstream signaling pathways following mitochondrial dysfunction may contribute to granulosa cell death and female reproductive toxicity after exposure to Cd.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Pharmacology & Pharmacy

Subacute cadmium exposure promotes M1 macrophage polarization through oxidative stress-evoked inflammatory response and induces porcine adrenal fibrosis

Yujie Yao et al.

Summary: The study revealed that cadmium can induce porcine adrenal fibrosis by activating oxidative stress-mediated inflammatory signaling pathways and promoting polarization of macrophages towards the M1 phenotype.

TOXICOLOGY (2021)

Article Biochemistry & Molecular Biology

Ameliorative Effect of Selenomethionine on Cadmium-Induced Hepatocyte Apoptosis via Regulating PI3K/AKT Pathway in Chickens

Xiaoyu Xiong et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2020)

Article Biochemistry & Molecular Biology

Prohibitin levels regulate OMA1 activity and turnover in neurons

Corey J. Anderson et al.

CELL DEATH AND DIFFERENTIATION (2020)

Article Engineering, Environmental

Chlorpyrifos induces the apoptosis and necroptosis of L8824 cells through the ROS/PTEN/PI3K/AKT axis

Lanqiao Wang et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

Review Environmental Sciences

The Effects of Cadmium Toxicity

Giuseppe Genchi et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

Review Biochemistry & Molecular Biology

Cadmium-Induced Oxidative Stress: Focus on the Central Nervous System

Jacopo J. Branca et al.

ANTIOXIDANTS (2020)

Article Environmental Sciences

Protocatechuic acid mitigates cadmium-induced neurotoxicity in rats: Role of oxidative stress, inflammation and apoptosis

Ebtesam M. Al Olayan et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article Biochemistry & Molecular Biology

Mitochondrial fusion and maintenance of mitochondrial homeostasis in diabetic retinopathy

Arul J. Duraisamy et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

Review Geochemistry & Geophysics

Cadmium in soils and groundwater: A review

Andreas Kubier et al.

APPLIED GEOCHEMISTRY (2019)

Review Biochemistry & Molecular Biology

Cadmium and Plant Development: An Agony from Seed to Seed

Michiel Huybrechts et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Cell Biology

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

Rumani Singh et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Engineering, Environmental

The antagonistic effect of selenium on cadmium-induced apoptosis via PPAR-γ/PI3K/Akt pathway in chicken pancreas

Xi Jin et al.

JOURNAL OF HAZARDOUS MATERIALS (2018)

Review Cell Biology

Cadmium-induced neurotoxicity: still much ado

Jacopo Junio Valerio Branca et al.

NEURAL REGENERATION RESEARCH (2018)

Article Medical Laboratory Technology

Role of mitochondria in apoptotic and necroptotic cell death in the developing brain

Claire Thornton et al.

CLINICA CHIMICA ACTA (2015)

Article Gastroenterology & Hepatology

FAM3A Activates PI3K p110α/Akt Signaling to Ameliorate Hepatic Gluconeogenesis and Lipogenesis

Chunjiong Wang et al.

HEPATOLOGY (2014)

Article Ophthalmology

PEDF Improves Mitochondrial Function in RPE Cells During Oxidative Stress

Yuan He et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2014)

Article Food Science & Technology

Herbacetin induces apoptosis in HepG2 cells: Involvements of ROS and PI3K/Akt pathway

Yan Qiao et al.

FOOD AND CHEMICAL TOXICOLOGY (2013)