Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 244, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2022.114060
Keywords
PM2; 5; Lung injury; Probiotics; Gut Microbiota; Th17; Treg
Categories
Funding
- National Natural Science Foundation of China [82104824]
- China Postdoctoral Science Foundation [2020M683645XB, 2022M710566]
- Science and Technology of Sichuan Province [2020YFS0312]
- Health Commission of Sichuan Province [20PJ160]
- Xinglin Program of Chongqing TCM/TCM-integrated Key discipline [2021-ZDXK-bsh02]
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This study found that probiotic intervention can prevent lung damage caused by PM2.5, and the mechanisms mainly include inhibiting inflammatory response, regulating Th17/Treg balance, and maintaining intestinal environment stability.
The imbalance of intestinal microbiota and inflammatory response is crucial in the development of lung injury induced by PM2.5. In recent years, probiotics have attracted great attention for their health benefits in inflammatory diseases and regulating intestinal balance, but their intricate mechanisms need further experiments to elucidate. In our research, a rat lung damage model induced by PM2.5 exposure in real environment was established to explore the protective properties of probiotics on PM2.5 exposure injury and its related mechanism. The results indicated that compared with the AF control group, rats in the PM2.5 group gained weight slowly, ate less and had yellow hair. The results of pathological and immunohistochemical examinations showed that the inflammatory infiltration of lung tissue was alleviated after probiotic treatment. The Lung function results also showed the improvement effects of probiotics administration. In addition, probiotics could promote the balance of Th17 and Treg cells, inhibit cytokines expression (TNF-alpha, IL-6, IL-113, IL-17A), and increase the concentration of anti-inflammatory factors (IL-10, TGF-13). In addition, 16 S rRNA sequence analysis showed that probiotic treatment could reduce microbiota abundance and diversity, increase the abundance of possible beneficial bacteria, and decrease the abundance of bacteria associated with inflammation. In general, probiotic intervention was found to have preventive effects on the occurrence of PM2.5 induced pathological injury, and the mechanism was associate with to the inhibition of inflammatory response, regulation of Th17/Treg balance and maintenance of intestinal internal environment stability.
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