Journal
DYES AND PIGMENTS
Volume 205, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2022.110590
Keywords
Synovium; Targeting peptide; Fluorogenic probe; Peptide complex; Fluorescence imaging
Funding
- Basic Science Research Program through the National Research Foundation (NRF) of Korea - Ministry of Education [2018-R1A6A1A03025124]
- Bio & Medical Technology Development Program of the NRF of Korea - Ministry of Science ICT [2022- R1F1A1069954, 2022-M3A9H1014157, 2021-M3A9I5030523]
- Korea Health Technology R & D Project of the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI21C0239]
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A new synovium-homing tri-peptide, DRL, was developed through peptide screening and functionalized to visualize the synovium. The TAMRA-conjugated DRL, named DRL-TAM, demonstrated remarkable visualization ability on synovial-derived cells and synovial-related organs in cell screening and in vivo fluorescence imaging studies. This study opens up new possibilities for the diagnosis and treatment of synovium-related diseases.
The development of new cell-/organ-targeting peptides has been highlighted across various basic research fields and industries. In this work, a new synovium-homing tri-peptide, DRL, was developed through peptide screening and was functionalized to visualize the synovium via 5-carboxytetramethylrhodamine (TAMRA; TAM) conju-gation. The TAMRA-conjugated DRL, named DRL-TAM , showed a bright red emission in cells and tissues with high biocompatibility (low cytotoxicity and biotoxicity). In the cell screening and in vivo fluorescence imaging studies, DRL-TAM demonstrated a remarkable visualization ability on the synovial-derived cells and synovial-related organs. DRL-TAM, as an advanced next generation of synovium-homing peptide, could open up new possibilities for the synovium-related disease diagnosis and treatment.
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