Journal
DYES AND PIGMENTS
Volume 205, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2022.110541
Keywords
pH probe; Quinolizinium; Photo-induced electron transfer; Cellular imaging
Funding
- Shenzhen Science and Technology Innovation Commission [JCYJ20170818104257975]
- Hong Kong Research Grants Council [PolyU 153001/17P]
- State Key Laboratory of Chemical Biology and Drug Discovery
- Hong Kong Polytechnic University
- Innovation and Technology Commission [PRP/075/19FX]
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A new type of quinolizinium-based fluorescent probes has been developed for cell imaging with tunable pH responsiveness. These probes exhibit turn On fluorescence response upon acidification through modulation of photoinduced electron transfer (PET) from the N,N-dialkyl aniline substituent to the quinolizinium core skeleton. They demonstrate tunable emission properties and pH responsiveness with pKa ranging from <2.1 to 6.1, thanks to the steric effect of N,N-dialkyl anilines. Successful application for in vivo pH sensing in lysosome in live cells has been achieved.
A new class of quinolizinium-based tunable pH fluorescent probes for cell imaging was developed. The probes showed turn On fluorescence response upon acidification brought by a modulation of photoinduced electron transfer (PET) from the N,N-dialkyl aniline substituent to the quinolizinium core skeleton. These novel PET-based pH fluorescent probes displayed tunable emission properties in between 478 and 509 nm. Also, the probes exhibited tunable pH responsiveness with pKa ranging from <2.1 to 6.1 contributed by the steric effect of N,N-dialkyl anilines. They were successfully applied to in vivo pH sensing in lysosome in live cells.
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