Journal
DRUG DISCOVERY TODAY
Volume 27, Issue 11, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2022.103352
Keywords
Adipokines; Inflammation; Arthritis; Musculoskeletal diseases; Metabolic Syndrome
Categories
Funding
- Xunta de Galicia (Servizo Galego de Saude, SERGAS) [ISCIII/SER-GAS]
- Instituto de Salud Carlos III (ISCIII) and FEDER [18/00188, CD21/00042, RD21/0002/0025, PI20/00902]
- Xunta de Galicia [IN606A-2020/010]
- Secretaria de Estado de Universidades, Investigacion, Desarrollo e Innovacion, Ministerio de Universidades [FPU2018-04165]
- Research Executive Agency of the European Union [734899]
- Xunta de Galicia, Conselleria de Educacion, Universidade e Formacion Profesional and Conselleria de Economia, Emprego e Industria (GAIN) [GPC IN607B2019/10]
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Recent research has shown that adipokines play important roles not only in adipose signaling, but also in musculoskeletal diseases, potentially impacting disease progression and treatment response.
Adipokines are the principal mediators in adipose signaling. Nevertheless, besides their role in energy storage, these molecules can be produced by other cells, such as immune cells or chondrocytes. Given their pleiotropic effects, research over the past few years has also focused on musculoskeletal diseases, showing that these adipokines might have relevant roles in worsening the disease or improving the treatment response. In this review, we summarize recent advances in our understanding of adipokines and their role in the most prevalent musculoskeletal immune and inflammatory disorders.
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