Journal
DRUG DELIVERY
Volume 29, Issue 1, Pages 3213-3217Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717544.2022.2134507
Keywords
Prepontine cisternal; intrathecal; craniofacial; cancer pain; technical note
Categories
Funding
- National Natural Science Foundation of China [81671962]
- Key Research and Development Program of Hunan Province [2020SK2097]
- Key Laboratory of Hunan Province [2018TP1009]
- Huizhiyucai Project of the Third Xiangya Hospital, Central South University
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This study reports the experience of using intrathecal targeted drug delivery for the management of cancer-related craniofacial pain. By placing the catheter tip in the prepontine cistern, effective pain relief can be achieved without significant complications.
Intrathecal targeted drug delivery provides effective relief for cancer-related pain. However, its validation in management of craniofacial pain remains much less widely practiced, mainly due to the localized diffusion of analgesic agent with current approach. Here, we report our experience of prepontine cisternal routine for placement and implantation of intrathecal targeted drug delivery in two cases of cancer-related craniofacial pain. Lumbar cannulation was applied and the intrathecal catheter tip was positioned at the prepontine cistern under fluoroscopic guidance during the surgical implantation. Postoperative imaging confirmed that the catheter tip was successfully placed in the prepontine cisternal space. Satisfactory control of pain was achieved after intrathecal therapy, with significant reduction of background and breakthrough cancer pain. None obvious complications were observed in this study. Thus, our novel intrathecal routine may provide an alternative option for craniofacial pain caused by tumor, who were insufficiently treated by oral analgesic agents.
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