Journal
DRUG DELIVERY
Volume 29, Issue 1, Pages 2723-2733Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717544.2022.2112115
Keywords
Periplaneta americana; ulcerative colitis; oral drug administration; Eudragit S100; microparticles; polypeptide
Categories
Funding
- department of science & technology of Liaoning province [2021-BS-131]
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In this study, a pH-dependent drug delivery method using polymer cellulose acetate was developed to deliver active components to the inflamed colon for the treatment of ulcerative colitis, avoiding degradation in the stomach.
Ulcerative colitis (UC) is a chronic disease, which can result the inflammation of the rectum, mucosa of the colon, and submucosa. The active component such as polypeptide in Periplaneta americana, which is one of the most common insects in the nature, can be extracted to treat UC. However, the active components in Periplaneta americana extract (PAE) can be degraded in the stomach due to its extreme acidic environment and enzyme. In this study, we developed a pH-dependent drug delivery method using polymer cellulose acetate (Eudragit S100) as a carrier to deliver high concentration PAE to inflamed colon. Both in vitro and in vivo results showed the PAE-Eudragit-S100 could treat UC through delivering active drug components to colon without degradation.
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