Incidence, risk factors and predictors of cardiovascular mortality for aortic stenosis among patients with diabetes mellitus

Aims: To find the incidence, risk factors and predictors of cardiovascular (CV) mortality for aortic stenosis (AS) in patients with type 2 diabetes mellitus (T2DM). Methods: Between 2014 and 2019, 20,979 patients with T2DM who underwent echocardiography were enrolled for analysis. The mean follow-up period was 34 months. Multiple risk factors and outcomes for patients with and without AS were presented. Results: AS was present in 776 (3.70%) patients. Age, female, chronic kidney disease, hyperlipidemia, and peripheral arterial disease statistically increased risk of AS. The CV mortality (adjusted hazard ratio [aHR] = 1.97; 95% confidence interval [CI] 1.336 - 2.906, p < 0.001) and risk of hospitalization for heart failure (HHF) (aHR = 1.73, 95% CI 1.442-2.082, p < 0.001) were significantly increased in patients with AS, without significant differences in acute myocardial infarction and stroke. Severity of AS, body mass index (< 27 kg/m(2)), hyper-tension, hyperuricemia, left ventricular dysfunction (ejection fraction < 50%), and hematocrit (< 38%) were significantly associated with increased CV mortality and HHF. Conclusions: AS was associated with an increased risk of CV mortality and HHF in patients with T2DM.

Automated summary

This study aimed to investigate the incidence, risk factors, and predictors of cardiovascular mortality for aortic stenosis in type 2 diabetes patients. The results showed that aortic stenosis was associated with an increased risk of cardiovascular mortality and hospitalization for heart failure, with age, female gender, chronic kidney disease, hyperlipidemia, and peripheral arterial disease being significant risk factors for aortic stenosis.