Journal
DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 192, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2022.110096
Keywords
Sodium glucose cotransporter 2; Hyperglycemia; Ischemia; Mesangial cells; Pericytes
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SGLT2 is upregulated in mesangial cells and pericytes due to high glucose and ischemia, which can directly exacerbate ischemia in the kidney interstitial legion, heart, and brain. The overexpression of SGLT2 in these cells can lead to organ failures through damages or loss of capillaries and dysfunctions of mesangial cells, which can be attenuated by SGLT2 inhibitors.
SGLT2 is expressed in mesangial cells and pericytes, and is upregulated by high glucose and ischemia. Upregulated SGLT2 in both cells might directly worsen ischemia in kidney interstitial legion, heart and brain. The overexpression of SGLT2 in these cells could induce various organ failures via damages or loss of capillaries and dysfunctions of mesangial cells, which are attenuated by SGLT2 inhibitors.
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