1-h post-load plasma glucose for detecting early stages of prediabetes

Prediabetes is a very prevalent condition associated with an increased risk of developing diabetes and/or other chronic complications, in particular cardiovascular disorders. Early detection is therefore mandatory since therapeutic interventions may limit the development of these complications. Diagnosis of prediabetes is currently based on glycemic criteria (fasting plasma glucose (PG), and/or glycemia at 120 min during a 75 g oral glucose tolerance test (OGTT) and/or glycated hemoglobin (HbA1c). Accumulating longitudinal evi-dence suggests that a 1-hour PG >= 155 mg/dl (8.6 mmol/l) during the OGTT is an earlier marker of prediabetes than fasting PG, 2-h post-load PG, or HbA1c. There is substantial evidence demonstrating that the 1-h post -load PG is a more sensitive predictor of type 2 diabetes, cardiovascular disease, microangiopathy and mortal-ity compared with conventional glucose criteria.The aim of this review is to highlight the paramount importance of detecting prediabetes early in its patho-physiological course. Accordingly, as recommended by an international panel in a recent petition, 1-h post -load PG could replace current criteria for diagnosing early stages of prediabetes before prediabetes evolves as conventionally defined.(c) 2022 Elsevier Masson SAS. All rights reserved.

Automated summary

Prediabetes is a common condition associated with an increased risk of diabetes and chronic complications. Early detection and intervention can limit the development of complications. The measurement of 1-hour post-load plasma glucose (PG) is a more predictive marker for diabetes and cardiovascular diseases. Early detection of prediabetes is crucial.