Rituximab in Subepidermal Blistering Diseases

Letter Dermatology

The safety of rituximab for the treatment of autoimmune blistering diseases: A systematic review

Arooj Mohammed et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

Review Geriatrics & Gerontology

Treatment of Bullous Pemphigoid in People Aged 80 Years and Older: A Systematic Review of the Literature

Meital Oren-Shabtai et al.

Summary: Bullous pemphigoid commonly affects older adults, with systemic corticosteroids being the main therapy but having significant adverse effects. Topical corticosteroids show the highest complete response rate in older patients, while biologics like omalizumab and rituximab can achieve complete remission on minimal therapy, albeit with rituximab being associated with relatively high mortality rate. Topical corticosteroids remain the first-line treatment for bullous pemphigoid in older adults, while biological agents require careful patient selection.

DRUGS & AGING (2021)

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Article Dermatology

International multicentre observational study to assess the efficacy and safety of a 0.5 mg kg(-1) per day starting dose of oral corticosteroids to treat bullous pemphigoid

V. Hebert et al.

Summary: The study assessed the safety and efficacy of oral prednisone in treating bullous pemphigoid, with results showing that a dose of 0.5 mg kg(-1) per day can effectively control disease activity. This treatment option is suitable for patients with mild or moderate BP and good general condition.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Dermatology

International multicentre observational study to assess the efficacy and safety of a 0.5 mg kg(-1) per day starting dose of oral corticosteroids to treat bullous pemphigoid

V. Hebert et al.

Summary: The study found that a daily dose of 0.5 mg kg(-1) of oral prednisone is a safe and effective treatment option for patients with mild or moderate bullous pemphigoid, especially those with good general condition.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Dermatology