Rituximab in Subepidermal Blistering Diseases

Background: Although rituximab is known to be effective in the treatment of pemphigus, its role in subepidermal autoimmune blistering diseases is unclear and currently limited to off-label use. Summary: This is a meta-analysis of case reports, case series, and retrospective studies on the effectiveness and safety of rituximab in bullous pemphigoid, mucous membrane pemphigoid, ocular pemphigoid, and epidermolysis bullosa acquisita. We compared remission and relapse rates in patients who received rituximab with those who only received conventional medical therapy. Comparisons were also made among disease subgroups. Key Message: The present analysis suggests that patients with subepidermal autoimmune blistering diseases treated with rituximab achieve a higher rate of complete remission and encounter their first relapse after a longer time interval. However, time to remission and total relapse rates were similar between groups. Adverse events and mortality rates were no more common in patients who received rituximab. This analysis was limited by the absence of randomized controlled trials and the observation that rituximab was used as a late rescue therapy in most reports. In conclusion, rituximab may be effective in subepidermal blistering disease, but randomized controlled studies are required for the validation of current observational data.

Automated summary

This meta-analysis suggests that rituximab may be effective in achieving higher rates of complete remission and delayed first relapse in patients with subepidermal autoimmune blistering diseases. However, there were no significant differences in time to remission and total relapse rates between rituximab-treated patients and those who received conventional medical therapy. Adverse events and mortality rates were not increased in patients treated with rituximab. However, the limitations of this analysis include the absence of randomized controlled trials and the use of rituximab as a late rescue therapy in most cases. Further studies are needed to validate these observational findings.