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Unraveling Major Proteins of Mycobacterium tuberculosis Envelope

Journal

CURRENT PROTEOMICS
Volume 19, Issue 5, Pages 372-379

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570164619666220908141130

Keywords

Mycobacterium tuberculosis; cell envelope; cell membrane; proteins; tuberculosis; drug-resistant

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This review provides an overview of the importance of the cell envelope and the functions offered by the associated proteins. Selective targeting of the mycobacterial envelope has the potential to address the problems associated with the current drug regimen and could lead to the development of more effective and safer drugs against all forms of tuberculosis infections.
Although treatable, resistant form of tuberculosis (TB) has posed a major impediment to the effective TB control programme. As the Mycobacterium tuberculosis cell envelope is closely associated with its virulence and resistance, it is very important to understand the cell envelope for better treatment of causative pathogens. Cell membrane plays a crucial role in imparting various cell functions. Proteins being the functional moiety, it is impossible to characterize the functional properties based on genetic analysis alone. Proteomic based research has indicated mycobacterial envelope as a good source of antigens/proteins. Envelope/membrane and associated proteins have an anticipated role in biological processes, which could be of vital importance to the microbe, and hence could qualify as drug targets. This review provides an overview of the prominent and biologically important cell envelope and highlights the different functions offered by the proteins associated with it. Selective targeting of the mycobacterial envelope offers an untapped opportunity to address the problems associated with the current drug regimen and also will lead to the development of more potent and safer drugs against all forms of tuberculous infections.

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