Curcumin Combats against Organophosphate Pesticides Toxicity: A Review of the Current Evidence and Molecular Pathways

Organophosphate compounds are regarded as a class of pesticides that are used in farming. Their extensive use, especially in developing countries, is a serious public health problem. Numerous studies have shown the effects of these toxins on various parts of the human and other vertebrates' bodies, including the cardiovascular, hepatobiliary, renal, and reproductive systems. Curcumin is a polyphenol compound obtained from the rhizome of the Curcuma longa. Curcumin has been known as a dietary spice, food additive, and traditional medicine since many years ago. In recent decades, the medicinal characteristics, clinical aspects, and biological activity of curcumin have been extensively examined. The most examined positive characteristics of curcumin are its anti-inflammatory and anti-oxidant qualities. This review will deal with the pharmacological properties of curcumin as well as an update of currently available studies in terms of curcumin's uses and function against organophosphate pesticides-induced toxicity on different human organs.

Automated summary

Organophosphate compounds as pesticides are a serious public health issue, particularly in developing countries. Studies have shown their harmful effects on various systems in humans and vertebrates. Curcumin, derived from the rhizome of Curcuma longa, has been extensively studied for its anti-inflammatory and antioxidant properties. This review focuses on the pharmacological properties of curcumin and its role in combating organophosphate pesticide-induced toxicity in different human organs.