Related references
Note: Only part of the references are listed.A Review on Poly (ADP-ribose) Polymerase (PARP) Inhibitors and Synthetic Methodologies
Ying Li et al.
CURRENT MEDICINAL CHEMISTRY (2021)
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening
Stefan Gradl et al.
SLAS DISCOVERY (2021)
Histone methyltransferase SMYD2 selective inhibitor LLY-507 in combination with poly ADP ribose polymerase inhibitor has therapeutic potential against high-grade serous ovarian carcinomas
Asako Kukita et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)
Small-molecule inhibitors of lysine methyltransferases SMYD2 and SMYD3: current trends
Edoardo Fabini et al.
FUTURE MEDICINAL CHEMISTRY (2019)
Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2) Inhibitor GSK2816126 in Patients with Advanced Hematologic and Solid Tumors
Timothy A. Yap et al.
CLINICAL CANCER RESEARCH (2019)
Histone lysine methyltransferases in biology and disease
Dylan Husmann et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)
SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia
J. Bu et al.
LEUKEMIA (2018)
The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia
Eytan M. Stein et al.
BLOOD (2018)
Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation
Michael J. Thomenius et al.
PLOS ONE (2018)
Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression
Linda Xiaoyan Li et al.
CELL DEATH & DISEASE (2018)
Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase
Yan Xiong et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity
Kenneth D. Bromberg et al.
NATURE CHEMICAL BIOLOGY (2017)
ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells
Lei Wang et al.
JOURNAL OF GASTRIC CANCER (2017)
Metabolism and disposition of the DOT1L inhibitor, pinometostat (EPZ-5676), in rat, dog and human
Nigel J. Waters et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2016)
Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor
Lorna H. Mitchell et al.
ACS MEDICINAL CHEMISTRY LETTERS (2016)
Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification
Wei-Lin Chen et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2016)
New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms
Sophie S. Spurr et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Discovery of novel small molecule inhibitors of lysine methyltransferase G9a and their mechanism in leukemia cell lines
Shukkoor M. Kondengaden et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer
Nicolas Reynoird et al.
GENES & DEVELOPMENT (2016)
Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays
Shijie Chen et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2016)
Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors
Scott D. Cowen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas
Rishi G. Vaswani et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2
Erik Eggert et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription
Yasushi Takemoto et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors
Pei-Pei Kung et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase
Kyle V. Butler et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Identification of phenoxyacetamide derivatives as novel DOT1L inhibitors via docking screening and molecular dynamics simulation
Minghao Luo et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2016)
Structures of Nahuoic Acids B-E Produced in Culture by a Streptomyces sp Isolated from a Marine Sediment and Evidence for the Inhibition of the Histone Methyl Transferase SETD8 in Human Cancer Cells by Nahuoic Acid A
David E. Williams et al.
JOURNAL OF ORGANIC CHEMISTRY (2016)
The molecular hallmarks of epigenetic control
C. David Allis et al.
NATURE REVIEWS GENETICS (2016)
Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets
Glenn S. Van Aller et al.
STRUCTURE (2016)
Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8
Russell A. Judge et al.
ACS MEDICINAL CHEMISTRY LETTERS (2016)
Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket
Clemens Scheufler et al.
ACS MEDICINAL CHEMISTRY LETTERS (2016)
Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach
Chao Chen et al.
ACS MEDICINAL CHEMISTRY LETTERS (2016)
ZLD1122, a novel EZH2 and EZH1 small molecular inhibitor, blocks H3K27 methylation and diffuse large B cell lymphoma cell growth
Tiantao Gao et al.
RSC ADVANCES (2016)
Selective inhibition of EZH2 by ZLD1039 blocks H3K27methylation and leads to potent anti-tumor activity in breast cancer (vol 6, 20864, 2016)
Xuejiao Song et al.
SCIENTIFIC REPORTS (2016)
Nonhistone Lysine Methylation in the Regulation of Cancer Pathways
Scott M. Carlson et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)
Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer
Chuncheng Hao et al.
CANCER LETTERS (2015)
Structure and Function of SET and MYND Domain-Containing Proteins
Nicholas Spellmon et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)
LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2
Hannah Nguyen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
A SMYD3 Small-Molecule Inhibitor Impairing Cancer Cell Growth
Alessia Peserico et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2015)
Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening
Fanwang Meng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation
Xing Liu et al.
NUCLEIC ACIDS RESEARCH (2015)
Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2
Ramzi F. Sweis et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity
John E. Campbell et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
Selective Inhibitors of Protein Methyltransferases
H. Uemit Kaniskan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Critical roles of non-histone protein lysine methylation in human tumorigenesis
Ryuji Hamamoto et al.
NATURE REVIEWS CANCER (2015)
Small-Molecule Inhibitors of SETD8 with Cellular Activity
Gil Blum et al.
ACS CHEMICAL BIOLOGY (2014)
SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation
Ryuji Hamamoto et al.
CANCER LETTERS (2014)
Deregulated expression of selected histone methylases and demethylases in prostate carcinoma
Filipa Quintela Vieira et al.
ENDOCRINE-RELATED CANCER (2014)
The methyltransferase G9a regulates HoxA9-dependent transcription in AML
Bernhard Lehnertz et al.
GENES & DEVELOPMENT (2014)
Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma
Lucy Gossage et al.
GENES CHROMOSOMES & CANCER (2014)
Association of MLL3 expression with prognosis in gastric cancer
B. Li et al.
GENETICS AND MOLECULAR RESEARCH (2014)
Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8
Anqi Ma et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
SMYD2 is highly expressed in pediatric acute lymphoblastic leukemia and constitutes a bad prognostic factor
Luis Henrique Toshihiro Sakamoto et al.
LEUKEMIA RESEARCH (2014)
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer
Pawel K. Mazur et al.
NATURE (2014)
Role of Histone Lysine Methyltransferases SUV39H1 and SETDB1 in Gliomagenesis: Modulation of Cell Proliferation, Migration, and Colony Formation
Anastasia Spyropoulou et al.
NEUROMOLECULAR MEDICINE (2014)
Effect of the downregulation of SMYD3 expression by RNAi on RIZ1 expression and proliferation of esophageal squamous cell carcinoma
Shang-Wen Dong et al.
ONCOLOGY REPORTS (2014)
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells
Dalia Barsyte-Lovejoy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Structure-activity relationship studies of SETD8 inhibitors
Anqi Ma et al.
MEDCHEMCOMM (2014)
Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a
Ramzi F. Sweis et al.
ACS MEDICINAL CHEMISTRY LETTERS (2014)
The Histone Methyltransferase SMYD2 Methylates PARP1 and Promotes Poly (ADP-ribosyl)ation Activity in Cancer Cells
Lianhua Piao et al.
NEOPLASIA (2014)
An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
Kyle D. Konze et al.
ACS CHEMICAL BIOLOGY (2013)
Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas
Adam M. Fontebasso et al.
ACTA NEUROPATHOLOGICA (2013)
Bromo-deaza-SAH: A potent and selective DOT1L inhibitor
Wenyu Yu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: Reducing cytotoxicity by structural simplification
Shinya Fujishiro et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
Scott R. Daigle et al.
BLOOD (2013)
Identification of EZH2 and EZH1 Small Molecule Inhibitors with Selective Impact on Diffuse Large B Cell Lymphoma Cell Growth
Shivani Garapaty-Rao et al.
CHEMISTRY & BIOLOGY (2013)
The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis
Daechun Kang et al.
GENES CHROMOSOMES & CANCER (2013)
Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP
Feng Liu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases
Fanny L. Cherblanc et al.
NATURE CHEMICAL BIOLOGY (2013)
Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity
Stine Jorgensen et al.
NUCLEIC ACIDS RESEARCH (2013)
The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer
T. Ezponda et al.
ONCOGENE (2013)
Nahuoic Acid A Produced by a Streptomyces sp Isolated From a Marine Sediment Is a Selective SAM-Competitive Inhibitor of the Histone Methyltransferase SETD8
David E. Williams et al.
ORGANIC LETTERS (2013)
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
Sarah K. Knutson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Regulation of estrogen receptor a by histone methyltransferase SMYD2-mediated protein methylation
Xi Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Protein methylation at the surface and buried deep: thinking outside the histone box
Steven G. Clarke
TRENDS IN BIOCHEMICAL SCIENCES (2013)
A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma
Yuan Yuan et al.
ACS CHEMICAL BIOLOGY (2012)
Methylation by Set9 modulates FoxO3 stability and transcriptional activity
Daniel R. Calnan et al.
AGING-US (2012)
SMYD3 Promotes Cancer Invasion by Epigenetic Upregulation of the Metalloproteinase MMP-9
Alicia M. Cock-Rada et al.
CANCER RESEARCH (2012)
Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression
Masashi Takawa et al.
CANCER RESEARCH (2012)
Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation
Glenn S. Van Aller et al.
EPIGENETICS (2012)
PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription
David B. Beck et al.
GENES & DEVELOPMENT (2012)
Synthesis and Structure-Activity Relationship Investigation of Adenosine-Containing Inhibitors of Histone Methyltransferase DOT1L
Justin L. Anglin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2
Weihong Zheng et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells
Junko Kikuchi et al.
LUNG CANCER (2012)
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
Michael T. McCabe et al.
NATURE (2012)
Topological domains in mammalian genomes identified by analysis of chromatin interactions
Jesse R. Dixon et al.
NATURE (2012)
New lysine methyltransferase drug targets in cancer
Tobias Wagner et al.
NATURE BIOTECHNOLOGY (2012)
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
Sarah K. Knutson et al.
NATURE CHEMICAL BIOLOGY (2012)
Epigenetic protein families: a new frontier for drug discovery
Cheryl H. Arrowsmith et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
Michael T. McCabe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
Wei Qi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
Jens G. Lohr et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of Glucocorticoid Receptor target genes
Danielle Bittencourt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
Wenyu Yu et al.
NATURE COMMUNICATIONS (2012)
Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B
Hyun-Soo Cho et al.
NATURE COMMUNICATIONS (2012)
RB1 Methylation by SMYD2 Enhances Cell Cycle Progression through an Increase of RB1 Phosphorylation
Hyun-Soo Cho et al.
NEOPLASIA (2012)
Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis
Erica Ballabio et al.
Cancers (2012)
Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
Scott R. Daigle et al.
CANCER CELL (2011)
High-Resolution Genome-wide Mapping of the Primary Structure of Chromatin
Zhenhai Zhang et al.
CELL (2011)
Essential role of DOT1L in maintaining normal adult hematopoiesis
Anh T. Nguyen et al.
CELL RESEARCH (2011)
Regulation of chromatin by histone modifications
Andrew J. Bannister et al.
CELL RESEARCH (2011)
Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein
Simon M. Carr et al.
EMBO JOURNAL (2011)
DOT1L regulates dystrophin expression and is critical for cardiac function
Anh T. Nguyen et al.
GENES & DEVELOPMENT (2011)
The diverse functions of Dot1 and H3K79 methylation
Anh Tram Nguyen et al.
GENES & DEVELOPMENT (2011)
Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines
Feng Liu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies
Yuan Yao et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
Ryan D. Morin et al.
NATURE (2011)
The Polycomb complex PRC2 and its mark in life
Raphael Margueron et al.
NATURE (2011)
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
Masoud Vedadi et al.
NATURE CHEMICAL BIOLOGY (2011)
Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36
Sergio Fernandes de Almeida et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Condensed DNA: Condensing the concepts
Vladimir B. Teif et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2011)
Structural Basis of Substrate Methylation and Inhibition of SMYD2
Andrew D. Ferguson et al.
STRUCTURE (2011)
Coupling mitosis to DNA replication: The emerging role of the histone H4-lysine 20 methyltransferase PR-Set7
Julien Brustel et al.
TRENDS IN CELL BIOLOGY (2011)
Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2
Mohamed Abu-Farha et al.
JOURNAL OF MOLECULAR CELL BIOLOGY (2011)
A role for DOT1L in MLL-rearranged leukemias
Kathrin M. Bernt et al.
EPIGENOMICS (2011)
PARP inhibitors: its role in treatment of cancer
Alice Chen
Chinese Journal of Cancer (2011)
SET/MYND Lysine Methyltransferases Regulate Gene Transcription and Protein Activity
Kristin Leinhart et al.
GENES (2011)
The NSD3L histone methyltransferase regulates cell cycle and cell invasion in breast cancer cells
Zhangle Zhou et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Epigenetic regulator MLL2 shows altered expression in cancer cell lines and tumors from human breast and colon
Thanemozhi G. Natarajan et al.
CANCER CELL INTERNATIONAL (2010)
Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL Oncogenes
Ming-Jin Chang et al.
CANCER RESEARCH (2010)
Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
Gerben Duns et al.
CANCER RESEARCH (2010)
The Language of Histone Crosstalk
Jung-Shin Lee et al.
CELL (2010)
SET7/9 mediated methylation of non-histone proteins in mammalian cells
Sriharsa Pradhan et al.
Epigenetics (2010)
Methylation of the Retinoblastoma Tumor Suppressor by SMYD2
Louis A. Saddic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53
Jing Huang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases
Yanqi Chang et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Total Synthesis of (+)-Chaetocin and its Analogues: Their Histone Methyltransferase G9a Inhibitory Activity
Eriko Iwasa et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
CoCoCo: a free suite of multiconformational chemical databases for high-throughput virtual screening purposes
Alberto Del Rio et al.
MOLECULAR BIOSYSTEMS (2010)
Lysine Methylation Regulates E2F1-Induced Cell Death
Haroula Kontaki et al.
MOLECULAR CELL (2010)
EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization
S. Goyama et al.
LEUKEMIA (2010)
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
Gorica Nikoloski et al.
NATURE GENETICS (2010)
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
Ryan D. Morin et al.
NATURE GENETICS (2010)
Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling
Ming Hu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes
Jinbo Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Targeting the dynamic HSP90 complex in cancer
Jane Trepel et al.
NATURE REVIEWS CANCER (2010)
Covalent histone modifications - miswritten, misinterpreted and mis-erased in human cancers
Ping Chi et al.
NATURE REVIEWS CANCER (2010)
Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma
Shuhei Komatsu et al.
CARCINOGENESIS (2009)
An operational definition of epigenetics
Shelley L. Berger et al.
GENES & DEVELOPMENT (2009)
A Novel Mammalian Flavin-dependent Histone Demethylase
Aristotele Karytinos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a
Feng Liu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability
Renee D. Paulsen et al.
MOLECULAR CELL (2009)
Protein methyltransferases as a target class for drug discovery
Robert A. Copeland et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294
Yanqi Chang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells
Pierre-Olivier Esteve et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Emerging roles of E2Fs in cancer: an exit from cell cycle control
Hui-Zi Chen et al.
NATURE REVIEWS CANCER (2009)
Role of histone modifications in defining chromatin structure and function
Kathy A. Gelato et al.
BIOLOGICAL CHEMISTRY (2008)
Multiple myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity
Ji-Young Kim et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Regulation of estrogen receptor α by the SET7 lysine methyltransferase
Krithika Subramanian et al.
MOLECULAR CELL (2008)
Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms
Raphael Margueron et al.
MOLECULAR CELL (2008)
The histone methyltransferase SET8 is required for S-phase progression
Stine Jorgensen et al.
JOURNAL OF CELL BIOLOGY (2007)
New nomenclature for chromatin-modifying enzymes
C. David Allis et al.
CELL (2007)
The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3
Masaki Kunizaki et al.
CANCER RESEARCH (2007)
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
Sean D. Taverna et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
Modulation of p53 function by SET8-mediated methylation at lysine 382
Xiaobing Shi et al.
MOLECULAR CELL (2007)
NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis
Gang G. Wang et al.
NATURE CELL BIOLOGY (2007)
High-resolution profiling of histone methylations in the human genome
Artern Barski et al.
CELL (2007)
SET and MYND domain-containing protein 3 decreases sensitivity to dexamethasone and stimulates cell adhesion and migration in NIH3T3 cells
Xue-Gang Luo et al.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2007)
The mammalian epigenome
Bradley E. Bernstein et al.
CELL (2007)
Chromatin modifications and their function
Tony Kouzarides
CELL (2007)
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase
Stefan Kubicek et al.
MOLECULAR CELL (2007)
Repression of p53 activity by Smyd2-mediated methylation
Jing Huang et al.
NATURE (2006)
The retinoblastoma tumor-suppressor gene, the exception that proves the rule
D. W. Goodrich
ONCOGENE (2006)
Enhanced SMYD3 expression is essential for the growth of breast cancer cells
R Hamamoto et al.
CANCER SCIENCE (2006)
A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5′ flanking region of SMYD3 is a risk factor for human cancers
M Tsuge et al.
NATURE GENETICS (2005)
Molecular pathogenesis and a consequent classification of multiple myeloma
PL Bergsagel et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9
D Greiner et al.
NATURE CHEMICAL BIOLOGY (2005)
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications
DR Ciocca et al.
CELL STRESS & CHAPERONES (2005)
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9
M Tachibana et al.
GENES & DEVELOPMENT (2005)
The nucleosome: From genomic organization to genomic regulation
S Khorasanizadeh
CELL (2004)
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells
R Hamamoto et al.
NATURE CELL BIOLOGY (2004)
Histone demethylation mediated by the nuclear arnine oxidase homolog LSD1
YJ Shi et al.
CELL (2004)
Regulation of p53 activity through lysine methylation
S Chuikov et al.
NATURE (2004)
Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase
K Sawada et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Isolation of p53-target genes and their functional analysis
Y Nakamura
CANCER SCIENCE (2004)
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
AP Bracken et al.
EMBO JOURNAL (2003)
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
CG Kleer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders
M Autiero et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2003)
Structure of the catalytic domain of human DOT1L, a Non-SET domain nucleosomal histone methyltransferase
JR Min et al.
CELL (2003)
The active site of the SET domain is constructed on a knot
SA Jacobs et al.
NATURE STRUCTURAL BIOLOGY (2002)
Structure of the neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase
X Zhang et al.
CELL (2002)
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis
M Tachibana et al.
GENES & DEVELOPMENT (2002)
Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase
J Fang et al.
CURRENT BIOLOGY (2002)
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation
K Nishioka et al.
GENES & DEVELOPMENT (2002)
MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia
M Ruault et al.
GENE (2002)
Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase
HB Wang et al.
MOLECULAR CELL (2001)
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability
AHFM Peters et al.
CELL (2001)
SET domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3
M Tachibana et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression
D O'Carroll et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Regulation of chromatin structure by site-specific histone H3 methyltransferases
S Rea et al.
NATURE (2000)
The language of covalent histone modifications
BD Strahl et al.
NATURE (2000)
Share Paper
