Novel Proline Derivatives for Treating COVID-19

Article Chemistry, Medicinal

Novel Nitrile Peptidomimetics for Treating COVID-19

C. S. Brian Chia

ACS Medicinal Chemistry Letters (2022)

Review Biochemistry & Molecular Biology

An overview of current drugs and prophylactic vaccines for coronavirus disease 2019 (COVID-19)

Armina Alagheband Bahrami et al.

Summary: Designing and producing an effective vaccine is crucial in reducing and controlling the spread of diseases. Many companies have invested significant resources in developing vaccines during the COVID-19 pandemic. The available COVID-19 vaccines can be classified into four platforms, and various drugs have been found to affect the progression of the disease.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

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Review Biochemistry & Molecular Biology

Molecular and Clinical Investigation of COVID-19: From Pathogenesis and Immune Responses to Novel Diagnosis and Treatment

Narjes Riahi Kashani et al.

Summary: This review provides up-to-date knowledge on the origin and evolution, structure, genetic diversity, route of transmission, pathogenesis, new diagnostic, and treatment strategies of SARS-CoV-2 (Alpha to Omicron), as well as the psychological and economic impact of the COVID-19 pandemic on individuals and their lives worldwide.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Article Chemistry, Medicinal

Evolutionary and Structural Insights about Potential SARS-CoV-2 Evasion of Nirmatrelvir

Kai S. Yang et al.

Summary: The approval of the combination therapy PAXLOVID has boosted morale in fighting the COVID-19 pandemic. The analysis in the article discusses possible mutations in the M-Pro that could lead to acquired viral resistance to nirmatrelvir and its implications for fighting future drug-resistant viral variants.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Review Multidisciplinary Sciences

Remdesivir for the treatment of patients hospitalized with COVID-19 receiving supplemental oxygen: a targeted literature review and meta-analysis

Rachel Beckerman et al.

Summary: This study conducted a network meta-analysis to assess the efficacy of remdesivir in hospitalized patients with COVID-19 requiring supplemental oxygen. The results showed that remdesivir can reduce mortality and improve recovery among COVID-19 patients, particularly those receiving supplemental oxygen treatment.

SCIENTIFIC REPORTS (2022)

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Review Pharmacology & Pharmacy

Potential SARS-CoV-2 main protease inhibitors

Riddhidev Banerjee et al.

Summary: This review focuses on recent developments in the search for small-molecule inhibitors targeting the SARS-CoV-2 M-pro, aiming at discovering and designing drugs targeting the key target in the viral replication cycle.

DRUG DISCOVERY TODAY (2021)

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Review Medicine, General & Internal

Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality: systematic review and meta-analysis

Stella Talic et al.

Summary: This systematic review and meta-analysis suggest that personal protective and social measures like handwashing, mask wearing, and physical distancing are associated with reductions in the incidence of COVID-19. However, due to heterogeneity of the studies, meta-analysis for other interventions like quarantine, isolation, universal lockdowns, and closures was not possible, and further research is needed.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Medicine, General & Internal