Journal
CURRENT MEDICINAL CHEMISTRY
Volume 30, Issue 35, Pages 3942-3954Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867329666221006115329
Keywords
Alpha lipoic acid; oxidative stress; inflammation; novel therapeutic use; lipid peroxidation; metal overload
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Alpha-lipoic acid (ALA) is a potent antioxidant used in the management of diabetic neuropathy and has potential applications in other diseases related to oxidative stress, inflammation, and metal overload. This review summarizes recent clinical trials and describes the uses of ALA in managing neuropathies. The unique pharmacological actions of ALA, combined with its low toxicity, have prompted trials on its potential therapeutic uses in diseases associated with increased oxidative stress, inflammation, and metal overload.
Alpha-lipoic acid (ALA) is a potent antioxidant used in the management of diabetic neuropathy due to its ability to prevent neuronal lipid peroxidation. ALA also chelates transition metals, which can be beneficial in some diseases related to metal overload. Due to its unique antioxidant properties, ALA has potential novel applications in other diseases related to oxidative stress and inflammation. This review summarizes aspects of recent clinical trials and describes the uses of ALA in managing neuropathies. The unique pharmacological actions of ALA, coupled with relatively low toxicity, have led to several trials on the potential therapeutic uses of ALA in the management of diseases associated with increased oxidative stress, inflammation, and metal overload.
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