Journal
CURRENT GENETICS
Volume 68, Issue 5-6, Pages 537-550Publisher
SPRINGER
DOI: 10.1007/s00294-022-01254-y
Keywords
Peroxisomes; ER; Contact sites; Yeast; Pex30; Pex11
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Funding
- Department of Biotechnology (DBT), Government of India [BT/PR25097/NER/95/1013/2017]
- Top-up of Start-Up grant from IIT Guwahati
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Peroxisomes are dynamic organelles involved in various cellular functions, and their biogenesis and inter-organelle contacts are regulated by two protein families, Pex11 and Pex30.
Peroxisomes are highly dynamic organelles present in most eukaryotic cells. They also play an important role in human health and the optimum functioning of cells. An extensive repertoire of proteins is associated with the biogenesis and function of these organelles. Two protein families that are involved in regulating peroxisome number in a cell directly or indirectly are Pex11 and Pex30. Interestingly, these proteins are also reported to regulate the contact sites between peroxisomes and other cell organelles such as mitochondria, endoplasmic reticulum and lipid droplets. In this manuscript, we review our current knowledge of the role of these proteins in peroxisome biogenesis in various yeast species. Further, we also discuss in detail the role of these protein families in the regulation of inter-organelle contacts in yeast.
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