Cell death: All roads lead to mitochondria

Mitochondria are central to apoptosis, an immunologically silent form of cell death. The mitochondrial, or ''intrinsic'', apoptotic pathway is activated when the permeabilized mitochondrial membrane of stressed cells releases apoptotic effectors. A new study now characterizes how mitochondria are involved in the switch from pyroptotic to necroptotic cell death.

Automated summary

Mitochondria play a crucial role in cell death by activating the apoptotic pathway and being involved in the transition of cell death forms.