Journal
COORDINATION CHEMISTRY REVIEWS
Volume 469, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2022.214687
Keywords
MSNs-based nanoplatforms; Nanodynamic therapy; Radicals; Synergistic therapy; Multimodal theranostics
Categories
Funding
- National Natural Science Foundation of China [81603058]
- China Postdoctoral Science Foundation [2021M690483]
- Youth Project of Liaoning Provincial Education Department [LJKQZ2021030]
Ask authors/readers for more resources
Nanodynamic therapies using nanosensitizers triggered by various activators or reactions in tumor microenvironment have emerged as attractive strategies for treating deep-seated tumors. Mesoporous silica nanoparticles (MSNs) and MSNs-based hybrid nanoparticles are promising candidates for nanodynamic therapies due to their large surface area, high pore volume, biosafety, and easy surface modification. This review summarizes the antitumor mechanisms and latest progress in the construction, modification, and application of MSNs-based nanodynamic therapies, including photodynamic therapy, chemodynamic therapy, sonodynamic therapy, thermodynamic therapy, radiodynamic therapy, and electrodynamic therapy. The challenges and prospects for clinical applications of MSNs-based ROS-activated cancer treatments are also discussed.
Nanodynamic therapies that generate free radicals/reactive oxygen species (ROS) in situ have the possibility to treat deep-seated tumors and have gradually become attractive treatment strategies. Nanosensitizers are triggered either by exogenous/endogenous activators such as near-infrared light, ultrasound, X-ray, and microwave or by internal chemical/biological reaction in tumor microenvironment to generate free radicals for nanodynamic treatments. Mesoporous silica nanoparticles (MSNs) or MSNs-based hybrid nanoparticles are expected as suitable candidates in nanodynamic therapies, which possesses promising properties, such as large surface area, high pore volume, excellent biosafety, and easily modified surface. Herein, we explain and discuss the antitumor mechanism of MSNs-based nanodynamic therapies and multi-dynamic combination therapies. In addition, we summarize the latest progress in the construction, modification and application of MSNs-based nanodynamic therapies involving photodynamic therapy (PDT), chemodynamic therapy (CDT), sonodynamic therapy (SDT), thermodynamic therapy (TDT), radiodynamic therapy (RDT), and electrodynamic therapy (EDT). Finally, the challenges faced by MSNs-based nanodynamic therapies are elaborated and the development prospects for clinical applications of MSNs-based ROS-activated cancer treatments are also discussed in detail. (c) 2022 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available