4.1 Article

Ozanimod as a novel oral small molecule therapy for the treatment of Crohn's disease: The YELLOWSTONE clinical trial program

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Ozanimod: A First-in-Class Sphingosine 1-Phosphate Receptor Modulator for the Treatment of Ulcerative Colitis

David Choi et al.

Summary: Ozanimod has shown promising clinical efficacy in the treatment of ulcerative colitis, significantly increasing clinical remission rates and treatment effectiveness. While its unique safety profile requires extensive evaluation, as a new generation oral treatment, Ozanimod has the potential to play an important role in UC therapy.

ANNALS OF PHARMACOTHERAPY (2022)

Article Gastroenterology & Hepatology

Risk of Relapse in Patients With Ulcerative Colitis With Persistent Endoscopic Healing: A Durable Treatment Endpoint

Sushrut Jangi et al.

Summary: Patients with active UC treated-to-target of clinical remission, who achieve and maintain symptomatic remission and EH over consecutive endoscopies, have a low risk of relapse, particularly in a subset of patients who simultaneously achieve histological remission. Therefore, persistent EH may be an important indicator of deep remission.

JOURNAL OF CROHNS & COLITIS (2021)

Review Oncology

Immunogenicity Challenges Associated with Subcutaneous Delivery of Therapeutic Proteins

Nicole L. Jarvi et al.

Summary: The subcutaneous route of administration provides convenient delivery, but may lead to enhanced immunogenicity; unwanted antibody response can impact pharmacokinetics and efficacy of biologics; careful consideration is needed for the unique immunogenic challenges associated with subcutaneous protein administration.

BIODRUGS (2021)

Article Gastroenterology & Hepatology

STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD

Dan Turner et al.

Summary: STRIDE-II presents treatment targets for both adult and pediatric IBD, including long-term and short-term goals. These targets cover aspects such as clinical response, endoscopic healing, quality of life, and growth, providing guidance for improving patient outcomes.

GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Long-Term Efficacy and Safety of Ozanimod in Moderately to Severely Active Ulcerative Colitis: Results From the Open-Label Extension of the Randomized, Phase 2TOUCHSTONE Study

William J. Sandborn et al.

Summary: The study examined the long-term safety and efficacy of Ozanimod in patients with moderately to severely active ulcerative colitis, showing continued benefits in clinical response, endoscopic improvement, and biomarker measures with 1 mg daily dosage. The high rate of study participation and long-term benefit indicates the potential of Ozanimod as a treatment option for UC patients.

JOURNAL OF CROHNS & COLITIS (2021)

Article Gastroenterology & Hepatology

Complete Resolution of Mucosal Neutrophils Associates With Improved Long-Term Clinical Outcomes of Patients With Ulcerative Colitis

Rish K. Pai et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

Article Clinical Neurology

Effect of the sphingosine-1-phosphate receptor modulator ozanimod on leukocyte subtypes in relapsing MS

Sarah Harris et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2020)

Editorial Material Gastroenterology & Hepatology

Defining Endpoints and Biomarkers in Inflammatory Bowel Disease: Moving the Needle Through Clinical Trial Design

Maria T. Abreu et al.

GASTROENTEROLOGY (2020)

Article Gastroenterology & Hepatology

ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 2: IBD scores and general principles and technical aspects

Andreas Sturm et al.

JOURNAL OF CROHNS & COLITIS (2019)

Review Immunology

A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease

Qingdong Guan

JOURNAL OF IMMUNOLOGY RESEARCH (2019)

Article Health Care Sciences & Services

Development and validation of the Crohn's disease patient-reported outcomes signs and symptoms (CD-PRO/SS) diary

Peter D. R. Higgins et al.

JOURNAL OF PATIENT-REPORTED OUTCOMES (2018)

Article Gastroenterology & Hepatology

Development and validation of a histological index for UC

Mahmoud H. Mosli et al.

Article Pharmacology & Pharmacy

Results From the First-in-Human Study With Ozanimod, a Novel, Selective Sphingosine-1-Phosphate Receptor Modulator

Jonathan Q. Tran et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2017)

Review Clinical Neurology

Sphingosine 1-Phosphate Receptor Modulators for the Treatment of Multiple Sclerosis

Burhan Z. Chaudhry et al.

NEUROTHERAPEUTICS (2017)

Article Gastroenterology & Hepatology

Standardisation of Study Protocols - Pros and Cons

Geert D'Haens

JOURNAL OF CROHNS & COLITIS (2016)

Article Gastroenterology & Hepatology

Central Endoscopy Reading in Inflammatory Bowel Diseases

Julian Panes et al.

JOURNAL OF CROHNS & COLITIS (2016)

Article Medicine, General & Internal

Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease

B. G. Feagan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Clinical Neurology

Sphingosine 1-Phosphate Receptor Modulators in Multiple Sclerosis

Adnan M. Subei et al.

CNS DRUGS (2015)

Review Gastroenterology & Hepatology

Central endoscopy reads in inflammatory bowel disease clinical trials: The role of the imaging core lab

Harris Ahmad et al.

GASTROENTEROLOGY REPORT (2014)

Article Medicine, General & Internal

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

Ludwig Kappos et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Medicine, General & Internal

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

Jeffrey A. Cohen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Review Immunology

Finding a way out: lymphocyte egress from lymphoid organs

Susan R. Schwab et al.

NATURE IMMUNOLOGY (2007)

Article Medicine, General & Internal

Adalimumab induction therapy for Crohn disease previously treated with infliximab - A randomized trial

William J. Sandborn et al.

ANNALS OF INTERNAL MEDICINE (2007)