Multi-scale numerical simulation on mechano-transduction of osteocytes in different gravity fields

A three-dimensional model for osteocyte was established to research the mechanisms of mechano-transduction and amplification of primary cilium and osteocyte process in every gravity field. The results showed that significant stress concentration was observed in the area of physical connection between TES and the osteocyte process, where the fluid shear stress (FSS) was around two orders of magnitude higher than that in other areas. Due to the significant amplification effect of the TES structure on mechanical stimulation, making osteocyte process the optimal mechanical receptor. In microgravity, the mechanical signal conduction ability of the osteocyte decreased significantly..

Automated summary

A three-dimensional model of osteocyte was established to investigate the mechanisms of mechano-transduction and amplification of primary cilium and osteocyte process in different gravity fields. The study found that there was significant stress concentration in the area where TES and the osteocyte process were physically connected, with fluid shear stress (FSS) two orders of magnitude higher than in other areas. The TES structure had a significant amplification effect on mechanical stimulation, making the osteocyte process the optimal mechanical receptor. In microgravity, the mechanical signal conduction ability of the osteocyte decreased significantly.