Biomechanical validation of structural optimized patient-specific mandibular reconstruction plate orienting additive manufacturing

Background and objective: Owing to the unexpected in vivo fracture failure of the original design, struc-tural optimized patient-specific mandibular reconstruction plates (PSMRPs) were created to boost the biomechanical performance of bridging segmental bony defect in the mandibular reconstruction after tumor resection. This work aimed to validate the biomechanical benefit of the structural optimized PAM-RPs relative to the original design and compare the biomechanical performance between PSMRP1 with generic contour customization and PSMRP2 with a tangent arc upper margin in mandibular angle region.Methods: Finite Element Analysis (FEA) was used to evaluate the biomechanical behavior of mandibu-lar reconstruction assemblies (MRAs) concerning these two structural optimized PSMRPs by simulating momentary left group clenching and incisal clenching tasks. Bonded contact was set between mandibu-lar bone and fixation screws and between PSMRP and fixation screws in the MRA, while the frictionless connection was allocated between mandibular bone and PSMRP. The loads were applied on four principal muscles, including masseter, temporalis, lateral and medial pterygoid, whose magnitudes along the three orthogonal directions. The mandibular condyles were retrained in all three directions, and either the left molars or incisors area were restrained from moving vertically. Results: The peak von Mises stresses of structural optimized PSMRPs (264 MPa, 296 MPa) were way lower than that of the initial PSMRP design (393 MPa), with 33 and 25% reduction during left group clenching. The peak magnitude of von Mises stress, minimum principal stress, and maximum principal strain of PSMRP1 (264 MPa, 254 MPa;-297 MPa,-285 MPa; 0.0 020, 0.0 020) was lower than that of PSMRP2 (296 MPa, 286 MPa;-319 MPa,-306 MPa; 0.0 022, 0.0 020), while the peak maximum principal stress of PSMRP1 (275 MPa, 257 MPa) was higher than that of PSMRP2 (254 MPa, 235 MPa) during both left group clenching and incisal clenching tasks.Conclusions: The structural optimized PSMRPs reveal their biomechanical advantage compared with the original design. The PSMRP1 presents better biomechanical performance to the patient-specific mandibu-lar reconstruction than PSMRP2 as a result of its superior safety, preferable flexibility, and comparable stability. The PSMRP2 provides biomechanical benefit in reducing the maximum tension than PSMRP1, indicated by lower peak maximum principal stress, through tangent arc upper margin in mandibular an-gle region.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

The study validates the biomechanical benefit of the structural optimized patient-specific mandibular reconstruction plates (PSMRPs) compared to the original design. PSMRP1 shows better biomechanical performance in patient-specific mandibular reconstruction than PSMRP2, while PSMRP2 provides biomechanical benefit in reducing the maximum tension.