Journal
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
Volume 64, Issue 8, Pages 502-510Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1369/0022155416656940
Keywords
antimicrobial proteins; cytoskeleton; human labial gland; immunohistochemistry; minor salivary gland
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Human labial glands secrete mucous and serous substances for maintaining oral health. The normal microbial flora of the oral cavity is regulated by the acquired and innate immune systems. The localization and distribution of proteins of the innate immune system were investigated in serous acinar cells and the ductal system by the method of immunohistochemistry. Numerous antimicrobial proteins could be detected in the labial glands: -defensin-1, -2, -3; lysozyme; lactoferrin; and cathelicidin. Cytoskeletal components such as actin, myosin II, cytokeratins 7 and 19, - and -tubulin were predominantly observed in apical cell regions and may be involved in secretory activities.
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