Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 219, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2022.112857
Keywords
Curdlan oligosaccharides; pH-responsive micelles; Gut microbiota
Funding
- National Key R & D Program of China
- National Key Research and Development Program of China
- Program of Introducing Talents of Discipline to Universities
- [2021YFC2101100]
- [2017YFD0400302]
- [111-2-06]
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An amphiphilic polymer based on octenyl succinic anhydride-modified curdlan oligosaccharide (MCOS) was synthesized, which self-assembled into spherical micelles with pH-responsive property. It exhibited high loading capacity for polyphenols and showed sustained release in the simulated intestinal fluid, demonstrating potential for colon-targeted delivery of hydrophobic polyphenols.
An amphiphilic polymer based on octenyl succinic anhydride-modified curdlan oligosaccharide (MCOS) was synthesized. The critical micelle concentration of MCOS was 3.91 mu g.mL(-1). MCOS could self-assemble into spherical micelles with a particle size of 230.1 nm and a zeta potential of 37.9 mV. When used for polyphenol encapsulation, the loading capacity of curcumin and quercetin-co-encapsulated micelles was higher than that of single-polyphenol encapsulated micelles. In vitro gastrointestinal release test showed that the MCOS micelle presented a pH-dependent release, released a little polyphenol in simulated gastric fluid, but presented sustained release in the simulated intestinal fluid. The gastrointestinal-digested polyphenol-loaded micelles exhibited excellent antioxidant ability. In vitro human fecal fermentation indicated that the MCOS carrier could promote the production of short-chain fatty acids by gut microbiota and exhibited the highest relative abundance of Megamonas. In addition, the supplementation of curcumin and quercetin-co-loaded MCOS micelles increased the relative abundance of Bifidobacterium and inhibited the growth of Escherichia_Shigella. These findings indicated that the MCOS carrier can be potentially used for the colon-targeted delivery of hydrophobic polyphenols due to its pH-responsive property.
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