Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 217, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2022.112659
Keywords
Cellulosic textile; clove nano composite; Wound dressing; Wound healing
Funding
- Isfahan University of Medical Sciences, Iran
- Iran's National Elites Foundation
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This study develops a flexible cellulosic textile nanocomposite with clove herbal medicine and demonstrates its potential applications in antimicrobial activity and wound healing. The nano emulsion containing clove herbal medicine was confirmed to contain eugenol and had a mean size between 100 and 300 nm. The wound dressing showed high antimicrobial activity and significant improvement in in vivo wound healing and in vitro cellular compatibility.
Clove (Syzygium aromaticum) is one of the useful herbal medicine to prevent the bacteria infection. This herbal medicine plant shows high antimicrobial, antioxidant, and anti-inflammation activities because the essential oil and extract of this herb contains a rich source of phenolic compounds. The important phenolic compound of the herb is eugenol. In this study, we endeavored to develop the flexible cellulosic textile nanocomposite by dipping the cellulosic textile in a nano emulsion containing clove herbal medicine (32%wt). This nanocomposite was subjected to detail analyzes using Fourier Transform Infrared Spectroscopy (FTIR), field-emission scanning electron microscope (FESEM) and gas chromatography-mass spectrometry (GC-MS). The mean size of this nano emulsion as measured by electron microscopy is between 100 and 300 nm. The presence of eugenol in this nano emulsion has been confirmed by GC-MS. The wound dressing shows high antimicrobial activity against E. coli (3 +/- 0.11 mm), P. aeruginosa (2.8 +/- 0.06 mm), S. epidemidis (2.9 +/- 0.09 mm), and S. aureus (2.6 +/- 0.07 mm). This nano composite showed significant improvement in in vivo wound healing and in vitro cellular compatibility. Nearly 85% of the operation wound was healed during14 days. Accordingly, cellulosic textile/clove wound dressing can be a potential candidate for biomedical application and pre-clinical surveys.
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