Utility of Acetylenedicarboxylate in Organic Synthesis

Although, recent reviews demonstrated intensively on the reactivity of dimethyl acetylenedicarboxylate (DMAD) in organic synthesis, its reactions have still get importance addition in that field. Moreover, and due to the huge amount of published literatures dealing with the reactions of DMAD, we are trying to give more focus on the important missed reactions in addition to give more light to updated publications. DMAD is an organic compound with the formula (C6H6O4), and it is a diester in which the ester groups are conjugated with a triple bond. As such, DMAD is highly electrophilic and a widely employed as a dienophile in cycloaddition reactions, like the Diels-Alder reaction. Many organic compounds specially the heterocyclic ones were prepared via its reactions.