Journal
CLINICAL INFECTIOUS DISEASES
Volume 76, Issue 6, Pages 1121-1124Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciac867
Keywords
tuberculosis; TB; adverse events; elderly
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This study found that a significant proportion of patients being treated for drug-susceptible tuberculosis experienced moderate to severe adverse events that required treatment interruption or changes in drug regimens, with the elderly being more affected. Therefore, there is a need for safer and more effective treatment options.
Of 373 patients treated for drug-susceptible tuberculosis, 35.4% (46.2% aged >= 65 years) developed moderate/severe adverse events that required treatment interruption (34.8%), first-line drug discontinuation (26.2%, primarily pyrazinamide), second-line drug initiation (30.0%), and treatment duration up to 3.8 months longer. More safe and effective options are needed, including for the elderly.
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