4.7 Article

Higher Levels of Cerebrospinal Fluid and Plasma Neurofilament Light in Human Immunodeficiency Virus-associated Distal Sensory Polyneuropathy

Related references

Note: Only part of the references are listed.
Article Medicine, Research & Experimental

Neurofilament proteins as a potential biomarker in chemotherapy-induced polyneuropathy

Petra Huehnchen et al.

Summary: This study identifies neurofilament light chain (NFL) as a potential biomarker for chemotherapy-induced polyneuropathy (CIPN). In an in vitro model, NFL was released from sensory neurons treated with paclitaxel and showed an inverse correlation with cell viability. In a clinical study, NFL concentrations significantly increased in paclitaxel-treated patients with CIPN but not in patients receiving chemotherapy without CIPN or controls. This suggests that NFL could serve as a biomarker for early diagnosis of CIPN.

JCI INSIGHT (2022)

Review Neurosciences

CNS Neurotoxicity of Antiretrovirals

Tyler Lanman et al.

Summary: The development of novel antiretroviral treatments has marked a significant turning point in the battle against HIV, but HIV-associated neurocognitive disorder (HAND) remains prevalent. Research has explored the neurotoxic effects of these medications, raising questions about their impact on neurocognitive and neuropsychiatric function in HIV patients, while also discussing the concept of accelerated aging and potential treatments for HAND in HIV-positive individuals.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Neurofilament light chain, a biomarker for polyneuropathy in systemic amyloidosis

Jelger Louwsma et al.

Summary: The study found that sNfL levels are increased in patients with PNP in both AL and ATTRv amyloidosis, and are related to the severity of PNP in ATTRv amyloidosis. This suggests that sNfL may be a promising biomarker for detecting PNP.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2021)

Article Behavioral Sciences

Serum neurofilament light chain in chronic inflammatory demyelinating polyneuropathy

Tomohiro Hayashi et al.

Summary: The study aimed to investigate whether serum NfL levels can serve as a biomarker of disease activity and treatment response in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Results showed that baseline sNfL levels in CIDP patients before treatment were significantly higher than those in healthy controls, and these levels decreased significantly after treatment.

BRAIN AND BEHAVIOR (2021)

Review Pharmacology & Pharmacy

Neuroinflammation in HIV-Related Neuropathic Pain

Huan-Jun Lu et al.

Summary: Chronic pain is a common issue in HIV-infected patients, mainly neuropathic pain. The main mechanisms of neuropathic pain in HIV include injury caused by HIV proteins, nervous system sensitization, and neuroinflammation response, which still require further research for clarification.

FRONTIERS IN PHARMACOLOGY (2021)

Article Clinical Neurology

Prevention of HIV-1 TAT Protein-Induced Peripheral Neuropathy and Mitochondrial Disruption by the Antimuscarinic Pirenzepine

May Madi Han et al.

Summary: HIV-associated distal sensory polyneuropathy (HIV-DSP) affects about one third of people with HIV and is characterized by distal axon degeneration. This study found that modulation of TAT expression and use of a M1R antagonist, pirenzepine (PZ), may be a viable treatment for HIV-DSP. However, some neuropathic indices may be due to DOX treatment rather than TAT expression.

FRONTIERS IN NEUROLOGY (2021)

Article Clinical Neurology

Predictors of worsening neuropathy and neuropathic pain after 12 years in people with HIV

Ronald J. Ellis et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)

Review Clinical Neurology

Quality of Life in Painful Peripheral Neuropathies: A Systematic Review

Ayesha Girach et al.

PAIN RESEARCH & MANAGEMENT (2019)

Article Immunology

Chronic Distal Sensory Polyneuropathy Is a Major Contributor to Balance Disturbances in Persons Living With HIV

Duaa Z. Sakabumi et al.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2019)

Article Clinical Neurology

Serum and cerebrospinal neurofilament light chain levels in patients with acquired peripheral neuropathies

Sara Mariotto et al.

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM (2018)

Article Psychology, Clinical

Defining Neurocognitive Impairment in HIV: Deficit Scores Versus Clinical Ratings

K. Blackstone et al.

CLINICAL NEUROPSYCHOLOGIST (2012)

Article Immunology

Risk Factors for Falls in HIV-Infected Persons

Kristine M. Erlandson et al.

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2012)

Article Neurosciences

HIV peripheral neuropathy progression: protection with glucose-lowering drugs?

Scott R. Evans et al.

JOURNAL OF NEUROVIROLOGY (2012)

Article Neurosciences

Differential effects of HIV infected macrophages on dorsal root ganglia neurons and axons

Katrin Hahn et al.

EXPERIMENTAL NEUROLOGY (2008)

Article Clinical Neurology

Updated research nosology for HIV-associated neurocognitive disorders

A. Antinori et al.

NEUROLOGY (2007)

Article Neurosciences

Clinical validation of the NeuroScreen

RJ Ellis et al.

JOURNAL OF NEUROVIROLOGY (2005)