Monitoring the Awake and Anesthetized Unconscious States Using Bispectral Index and Electroencephalographic Connectivity Measures

Objective. Our objective was to compare three electroencephalography (EEG)-based methods with anesthesiologist clinical judgment of the awake and anesthetized unconscious states. Methods. EEG recorded from 25 channels and from four channel bilateral Bispectral index (BIS) electrodes were collected from 20 patients undergoing surgery with general anesthesia. To measure connectivity we applied Directed Transfer Function (DTF) in eight channels of the EEG, and extracted data from BIS over the same time segments. Shannon's entropy was applied to assess the complexity of the EEG signal. Discriminant analysis was used to evaluate the data in relation to clinical judgment. Results. Assessing anesthetic state relative clinical judgment, the bilateral BIS gave the highest accuracy (ACC) (95.4%) and lowest false positive discovery rate (FDR) (0.5%) . Equivalent DTF gave 94.5% for ACC and 2.6% for FDR. Combining all methods gave ACC = 94.9% and FDR = 1%. Generally, entropy scored lower on ACC and higher on FDR than the other methods (ACC 90.87% and FDR 4.6%). BIS showed at least a one minute delay in 18 of the 20 patients. Conclusions. Our results show that BIS and DTF both have a high ACC and low FDR. Because of time delays in BIS values, we recommend combining the two methods.

Automated summary

This study compared three EEG-based methods with anesthesiologist clinical judgment of awake and anesthetized unconscious states. The results showed that bilateral BIS method had the highest accuracy and lowest false positive rate, while entropy scored lower on accuracy and higher on false positive rate. Therefore, it is recommended to combine BIS and DTF methods to assess anesthesia state.