4.6 Article

New insights into SARS-CoV-2 Lumipulse G salivary antigen testing: accuracy, safety and short TAT enhance surveillance

Related references

Note: Only part of the references are listed.
Article Infectious Diseases

Preventing COVID-19 outbreaks through surveillance testing in healthcare facilities: a modelling study

Tim Litwin et al.

Summary: This study establishes an individual-based model to compare different testing strategies and finds that active testing in mental health hospitals and similar facilities can significantly reduce the number of COVID-19 outbreaks.

BMC INFECTIOUS DISEASES (2022)

Letter Medical Laboratory Technology

Spike vs. nucleocapsid serum antigens for COVID-19 diagnosis and severity assessment

Julien Favresse et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2022)

Article Medicine, General & Internal

Feasibility of SARS-CoV-2 Surveillance Testing Among Children and Childcare Workers at German Day Care Centers A Nonrandomized Controlled Trial

Johannes Forster et al.

Summary: The study conducted surveillance for SARS- CoV-2 in 9 German day care centers was feasible and well accepted. Mathematical modeling estimated that testing can minimize the spread of SARS-CoV-2 in day care centers.

JAMA NETWORK OPEN (2022)

Review Medicine, General & Internal

Updated picture of SARS-CoV-2 variants and mutations

Giuseppe Lippi et al.

Summary: The global burden of COVID-19 continues to rise, with cases and deaths increasing and no definitive treatment identified. While vaccines have been developed and widely used, their effectiveness is challenged by various factors, including the emergence of new variants.

DIAGNOSIS (2022)

Article Medicine, General & Internal

The University of Padua salivary-based SARS-CoV-2 surveillance program minimized viral transmission during the second and third pandemic wave

Daniela Basso et al.

Summary: Salivary-based surveillance with contact tracing effectively allowed to limit SARS-CoV-2 contagion, also in a population with a high incidence.

BMC MEDICINE (2022)

Letter Medical Laboratory Technology

Diagnostic accuracy of the ultrasensitive S-PLEX SARS-CoV-2 N electrochemiluminescence immunoassay

Giuseppe Lippi et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2022)

Article Medical Laboratory Technology

Ad interim recommendations for diagnosing SARS-CoV-2 infection by the IFCC SARS-CoV-2 variants working group

Giuseppe Lippi et al.

Summary: This document aims to update previous guidelines for diagnosing acute SARS-CoV-2 infection, considering the mutated genetics and altered characteristics of new lineages and sub-lineages. It provides indications for using different diagnostic strategies in specific clinical settings and offers tentative indications for identifying new lineages and sub-lineages of the virus.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2022)

Article Infectious Diseases

Surveillance and return to work of healthcare workers following SARS-CoV-2 Omicron variant infection, Sheffield, England, 17 January to 7 February 2022

Mohammed Raza et al.

Summary: Our surveillance of 240 healthcare workers from Sheffield Teaching Hospitals, England, shows that more than half of the affected staff can return to work before day 10 of isolation, and over 25% are eligible on day 6, pending two successive negative antigen tests. This is favorable for maintaining continuity of healthcare services.

EUROSURVEILLANCE (2022)

Article Medicine, General & Internal

Prospective health surveillance for COVID-19 among health care workers at a university medical center in Taiwan, January to June 2020

Sung-Ching Pan et al.

Summary: This article describes a prospective health surveillance of HCP and COVID-19 containment measures in a teaching hospital in Taiwan, successfully preventing COVID-19 infections.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2022)

Article Public, Environmental & Occupational Health

COVID-19 Mortality and Vaccine Coverage — Hong Kong Special Administrative Region, China, January 6, 2022–March 21, 2022

Dallas J. Smith et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2022)

Review Medicine, General & Internal

Performance of Antigen Detection Tests for SARS-CoV-2: A Systematic Review and Meta-Analysis

Anastasia Tapari et al.

Summary: This article conducts a systematic review and meta-analysis of antigen-based diagnostic tests for COVID-19, comparing different methods and performance. The findings suggest that the performance of tests varies based on sample sources and rapid methods, emphasizing the influence of viral load on test sensitivity.

DIAGNOSTICS (2022)

Review Medicine, General & Internal

Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection

Jacqueline Dinnes et al.

Summary: Accurate rapid diagnostic tests for SARS-CoV-2 infection are crucial in managing the COVID-19 pandemic. This review assesses the diagnostic accuracy of rapid antigen tests for the diagnosis of SARS-CoV-2 infection. The study finds that sensitivity varies in different population groups and that assays meeting appropriate performance standards could replace laboratory-based RT-PCR tests in certain situations. However, the variable sensitivity of antigen tests means that false negatives are possible. Further research is needed to evaluate the effectiveness of screening programs and the use of antigen test-based repeat testing strategies.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2022)

Review Medicine, General & Internal

Fujirebio Lumipulse SARS-CoV-2 antigen immunoassay: pooled analysis of diagnostic accuracy

Giuseppe Lippi et al.

Summary: This study provides a pooled analysis of the accuracy of the Fujirebio Lumipulse SARS-CoV-2 Antigen chemiluminescent immunoassay for diagnosing acute SARS-CoV-2 infections. The analysis shows that this method has good diagnostic sensitivity and specificity, making it a valuable option for complementing and integrating with molecular testing for SARS-CoV-2 in the current pandemic.

DIAGNOSIS (2022)

Review Biochemical Research Methods

SARS-CoV-2 pandemic: a review of molecular diagnostic tools including sample collection and commercial response with associated advantages and limitations

Harikrishnan Jayamohan et al.

Summary: The unprecedented global pandemic of SARS-CoV-2 has pushed the limits of modern viral diagnostics, highlighting both the advantages and limitations of current technologies while prompting efforts to expand diagnostic capacity. Key observations in functionality of current SARS-CoV-2 diagnostic methods have been put forth, with emphasis on critical aspects such as sample collection, testing models, and commercial responses. Integrated nature of assays is stressed, where issues in sample collection and preparation could impact overall performance in a clinical setting.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2021)

Article Virology

The effectiveness of active surveillance measures for COVID-19 cases in Pudong New Area Shanghai, China, 2020

Hanzhao Liu et al.

Summary: This study highlights the importance of active surveillance for potential COVID-19 cases, as demonstrated by shortened time intervals from illness onset to both the first medical visit and isolation, contributing to the effective control of the COVID-19 outbreak in Pudong, Shanghai.

JOURNAL OF MEDICAL VIROLOGY (2021)

Article Medicine, General & Internal

Head-to-Head Comparison of Rapid and Automated Antigen Detection Tests for the Diagnosis of SARS-CoV-2 Infection

Julien Favresse et al.

Summary: This study compared the clinical performance of five antigen detection tests for SARS-CoV-2 infection, with the VITROS automated assay showing 100% sensitivity and specificity for Ct values <= 33, outperforming rapid antigen detection tests and aligning with RT-PCR.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Infectious Diseases

Evaluation of false positives in the SARS-CoV-2 quantitative antigen test

Ryo Kobayashi et al.

Summary: The study highlights the frequency of false-positive reactions in SARS-CoV-2 quantitative antigen testing, especially in saliva samples. Non-specific reactions in the antigen test may lead to judgment differences compared to nucleic acid amplification testing. Centrifugation should be appropriately repeated before measurement to avoid false positives.

JOURNAL OF INFECTION AND CHEMOTHERAPY (2021)

Review Chemistry, Physical

Diagnostics for SARS-CoV-2 infections

Bhavesh D. Kevadiya et al.

Summary: The outbreak of SARS-CoV-2 causing COVID-19 has led to diverse and severe symptoms, making accurate diagnosis a key challenge. Rapid diagnosis and treatment measures are crucial in controlling the spread of the virus. The development of diagnostic tools, including nanomaterial-based ones, is essential in the fight against the pandemic.

NATURE MATERIALS (2021)

Article Medicine, General & Internal

Active Surveillance of Asymptomatic, Presymptomatic, and Oligosymptomatic SARS-CoV-2-Infected Individuals in Communities Inhabiting Closed or Semi-closed Institutions

Nicolas Ambrosis et al.

Summary: This study utilized a pooling approach to detect COVID-19 outbreaks at early stages in closed or semi-closed institutions, helping to contain the virus and potentially save lives of high-risk individuals. Sensitivity in sample pools was adequate with a high concordance rate compared to individual testing, demonstrating the efficiency and effectiveness of this strategy in low-to-moderate prevalence settings.

FRONTIERS IN MEDICINE (2021)

Article Medical Laboratory Technology

Salivary SARS-CoV-2 antigen rapid detection: A prospective cohort study

Daniela Basso et al.

Summary: Self-collected saliva is a valid alternative to NPS for SARS-CoV-2 detection by molecular testing, and also shows effectiveness in CLEIA antigen testing. CLEIA antigen is highly accurate in distinguishing positive and negative NPS, while saliva POC antigen has limited sensitivity depending on viral loads.

CLINICA CHIMICA ACTA (2021)

Article Public, Environmental & Occupational Health

ORIGINAL RESEARCH Underlying Medical Conditions and Severe Illness Among 540,667 Adults Hospitalized With COVID-19, March 2020-March 2021

Lyudmyla Kompaniyets et al.

Summary: This study identified that obesity, diabetes with complications, and anxiety disorders were the strongest risk factors for severe COVID-19 illness. Careful evaluation and management of underlying conditions among patients with COVID-19 can help reduce the risk of severe illness.

PREVENTING CHRONIC DISEASE (2021)

Article Public, Environmental & Occupational Health

Surveillance on Healthcare Workers During the First Wave of SARS-CoV-2 Pandemic in Italy: The Experience of a Tertiary Care Pediatric Hospital

Valentina Guarnieri et al.

Summary: Healthcare workers are central in managing the COVID-19 pandemic, and monitoring them through screening programs is crucial to prevent virus spread. A study conducted in a hospital in Florence found a certain percentage of infection among healthcare workers using RT-PCR and RST screening, with most infections occurring in non-COVID-19 dedicated areas.

FRONTIERS IN PUBLIC HEALTH (2021)

Review Medicine, General & Internal

Pandemics Throughout the History

Shrikanth Sampath et al.

Summary: Throughout history, deadly pandemics have occurred, causing death and destruction. Understanding the mechanisms of these pandemics is crucial for controlling the spread and preventing new ones. Public health agencies need to enhance preparedness to prevent future pandemics.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

Review Dentistry, Oral Surgery & Medicine

Exploring salivary diagnostics in COVID-19: a scoping review and research suggestions

Priyanka Kapoor et al.

Summary: Saliva as an alternate diagnostic sample for SARS-CoV-2 infection offers advantages such as simple sample collection method, point-of-care testing for initial screening in community or hospital settings, and reducing patient discomfort. However, there is heterogeneity and gaps in methodology in the current literature, highlighting the need for more robust study design to generate higher levels of evidence.

BDJ OPEN (2021)

Article Medical Laboratory Technology

SARS-CoV-2 identification and IgA antibodies in saliva: One sample two tests approach for diagnosis

Ada Aita et al.

CLINICA CHIMICA ACTA (2020)