4.7 Review

Liquid Biopsy and Immuno-Oncology for Advanced Nonsmall Cell Lung Cancer

Related references

Note: Only part of the references are listed.
Article Oncology

Camrelizumab Plus Carboplatin and Paclitaxel as First-Line Treatment for Advanced Squamous NSCLC (CameL-Sq): A Phase 3 Trial

Shengxiang Ren et al.

Summary: This study demonstrates the effectiveness and safety of camrelizumab plus chemotherapy as a first-line treatment for advanced squamous NSCLC, with on-treatment ctDNA dynamics showing potential as a predictor of efficacy.

JOURNAL OF THORACIC ONCOLOGY (2022)

Article Biochemistry & Molecular Biology

On-treatment blood TMB as predictors for camrelizumab plus chemotherapy in advanced lung squamous cell carcinoma: biomarker analysis of a phase III trial

Tao Jiang et al.

Summary: Camrelizumab plus chemotherapy has been shown to significantly improve the treatment outcomes for patients with advanced lung squamous cell carcinoma, but there is still a lack of predictive biomarkers.

MOLECULAR CANCER (2022)

Review Oncology

Targeting KRAS Mutant in Non-Small Cell Lung Cancer: Novel Insights Into Therapeutic Strategies

Anne-Laure Desage et al.

Summary: This article discusses new therapeutic strategies targeting KRAS G12C and promising approaches of combined therapy to overcome acquired resistance, highlighting their importance in non-small cell lung cancer.

FRONTIERS IN ONCOLOGY (2022)

Article Oncology

Clinical Utility of Liquid Biopsy (Cell-free DNA) Based EGFR Mutation Detection Post treatment Initiation as a Disease Monitoring Tool in Patients With Advanced EGFR-mutant NSCLC

Vichitra Behel et al.

Summary: This study assessed the potential of cell-free DNA (cfDNA)-based epidermal growth factor receptor (EGFR) mutation testing as a disease monitoring tool in patients with non-small cell lung cancer (NSCLC). The results showed that clearance of plasma-ctDNA post first-line treatment initiation is associated with significantly longer survival in patients with EGFR-mutant NSCLC.

CLINICAL LUNG CANCER (2022)

Review Medicine, General & Internal

Discordance of immunotherapy response predictive biomarkers between primary lesions and paired metastases in tumours: A systematic review and meta-analysis

Yutian Zou et al.

Summary: This study included 56 studies and found a high discordance rate for PD-L1, PD-1, PD-L2, and TIL levels, while TMB and MSI status were less likely to change between primary tumors and paired metastases.

EBIOMEDICINE (2021)

Article Oncology

Blood tumor mutation burden can predict the clinical response to immune checkpoint inhibitors in advanced non-small cell lung cancer patients

Xi Chen et al.

Summary: This study confirmed the feasibility of using large panels to estimate TMB and demonstrated that bTMB can serve as a potential biomarker for predicting the efficacy of ICIs in NSCLC. Patients with higher TMB values had superior progression-free survival, indicating the potential of TMB as a predictive biomarker for immunotherapy efficacy.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Article Oncology

PD-L1 Expression in Circulating Tumor Cells as a Promising Prognostic Biomarker in Advanced Non-small-cell Lung Cancer Treated with Immune Checkpoint Inhibitors

Filippo G. Dall'Olio et al.

Summary: This study found that PD-L1 expression on CTCs is correlated with overall survival in lung cancer patients, while CTC number is associated with baseline tumor size.

CLINICAL LUNG CANCER (2021)

Review Oncology

Meta-analysis of immune-related adverse events in phase 3 clinical trials assessing immune checkpoint inhibitors for lung cancer

Alvise Berti et al.

Summary: This study systematically reviewed and meta-analyzed the toxicity of ICIs in lung cancer patients, finding that immunotherapy has a lower risk of irAEs compared to chemotherapy, especially in monoimmunotherapy. Detailed comparisons between different ICIs provided treatment-related risk profiles for organ-specific irAEs.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

Review Oncology

Liquid Biopsy: From Discovery to Clinical Application

Catherine Alix-Panabieres et al.

Summary: CTC and ctDNA have been recognized as promising biomarkers with various clinical applications, including early cancer detection and therapeutic monitoring. However, challenges such as standardization and validation of clinical effectiveness need to be addressed in this dynamic field of translational cancer research.

CANCER DISCOVERY (2021)

Article Immunology

Novel Biomarkers of Dynamic Blood PD-L1 Expression for Immune Checkpoint Inhibitors in Advanced Non-Small-Cell Lung Cancer Patients

Qiao Yang et al.

Summary: This study found that increased expression of PD-L1 mRNA and exoPD-L1 in the early stage of ICIs treatment may serve as positive biomarkers of efficacy and overall survival in advanced NSCLC patients.

FRONTIERS IN IMMUNOLOGY (2021)

Article Oncology

Early plasma circulating tumor DNA (ctDNA) changes predict response to first-line pembrolizumab-based therapy in non-small cell lung cancer (NSCLC)

Biagio Ricciuti et al.

Summary: In patients with advanced NSCLC, changes in ctDNA levels after pembrolizumab treatment may predict treatment response before radiological assessment. Early decreases in ctDNA corresponded with clinical benefit, suggesting a potential role for ctDNA as an early pharmacodynamic biomarker of response or resistance to immunotherapies.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

Longitudinal Evaluation of PD-L1 Expression on Circulating Tumor Cells in Non-Small Cell Lung Cancer Patients Treated with Nivolumab

Mio Ikeda et al.

Summary: In non-small cell lung cancer patients, sequential evaluation of PD-L1 expression on CTCs can predict long-term efficacy of nivolumab treatment. Patients with PD-L1 positivity rates >= 7.7% at week 8 had significantly longer progression-free survival compared to those with <7.7%.

CANCERS (2021)

Article Oncology

Blood Tumor Mutational Burden as a Predictive Biomarker in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)

Yuhui Ma et al.

Summary: This study aimed to investigate the impact of blood tumor mutational burden (bTMB) on advanced NSCLC in Southwest China. The findings suggest that bTMB is a validated predictive biomarker for determining the clinical outcome of advanced NSCLC patients and may serve as a feasible predictor of the clinical benefit of immunotherapies in this population.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Plasma EGFR mutation abundance affects clinical response to first-line EGFR-TKIs in patients with advanced non-small cell lung cancer

Xiaohong Wang et al.

Summary: This study revealed that plasma EGFR mutation abundance impacts clinical response to EGFR-TKIs in advanced NSCLC patients, with patients above 0.1% abundance showing higher survival and objective response rates. Liquid biopsy screening based on plasma NGS is reliable for detecting drug resistance and actionable somatic mutations.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Article Medical Laboratory Technology

Programmed Cell Death Ligand 1-Expressing Circulating Tumor Cells: A New Prognostic Biomarker in Non-Small Cell Lung Cancer

Lea Sinoquet et al.

Summary: The presence of PD-L1(+) CTCs is associated with poor prognosis in patients with advanced NSCLC, showing low concordance with PD-L1 expression in tumor tissue, and further studies with larger samples are needed for confirmation.

CLINICAL CHEMISTRY (2021)

Article Oncology

Circulating tumor DNA as a biomarker for monitoring early treatment responses of patients with advanced lung adenocarcinoma receiving immune checkpoint inhibitors

Paul van der Leest et al.

Summary: Monitoring changes in circulating tumor DNA (ctDNA) levels can serve as a proxy for early tumor response to immunotherapy in metastasized non-small-cell lung cancer (NSCLC) patients, correlating with durable clinical benefit (DCB), progression-free survival (PFS), and overall survival (OS). Patients with a significant decrease (>30%) in ctDNA levels show longer PFS and OS, suggesting that ctDNA dynamics is a promising tool for assessing treatment outcomes in NSCLC patients receiving immune checkpoint inhibitors (ICI).

MOLECULAR ONCOLOGY (2021)

Article Oncology

Clinical potential of circulating free DNA and circulating tumour cells in patients with metastatic non-small-cell lung cancer treated with pembrolizumab

Patricia Mondelo-Macia et al.

Summary: In this study, the value of liquid biopsy analyses, including cfDNA and CTCs, as a prognostic or predictive tool in guiding pembrolizumab therapy for NSCLC was explored. Patients with high baseline cfDNA levels had poorer progression-free survival and overall survival, while those with unfavorable changes in cfDNA levels over 12 weeks had a higher risk of disease progression. Detection of CTCs using the CellSearch(R) system was associated with shorter PFS and OS in patients. The combination of CTCs and cfDNA levels was identified as an early independent predictor of disease progression.

MOLECULAR ONCOLOGY (2021)

Review Oncology

Prognostic significance of programmed cell death-ligand 1 expression on circulating tumor cells in various cancers: A systematic review and meta-analysis

Yushu Ouyang et al.

Summary: Our meta-analysis found that PD-L1 positive expression on CTCs predicted better survival prognosis for ICI treatment but worse survival for other therapies. Post-treatment PD-L1(+) CTCs predicted worse PFS and OS. The prognostic value of PD-L1(+) CTCs was significantly modulated by comparison models.

CANCER MEDICINE (2021)

Article Oncology

ctDNA Predicts Overall Survival in Patients With NSCLC Treated With PD-L1 Blockade or With Chemotherapy

Wei Zou et al.

Summary: In this study, the association between ctDNA MMPM levels at 6 weeks post-treatment and OS in advanced non-small-cell lung cancer patients treated with atezolizumab or docetaxel was investigated. The results suggest that ctDNA has the potential to serve as a noninvasive early liquid biopsy predictor for OS, highlighting the need for further studies to demonstrate its clinical utility.

JCO PRECISION ONCOLOGY (2021)

Article Oncology

Comprehensive analysis of blood-based biomarkers for predicting immunotherapy benefits in patients with advanced non-small cell lung cancer

Cheol-Kyu Park et al.

Summary: In patients with advanced non-small cell lung cancer undergoing immune checkpoint inhibitor treatment, levels of CTC, PBC, and cfDNA may serve as biomarkers for predicting survival benefits, aiding in risk stratification.

TRANSLATIONAL LUNG CANCER RESEARCH (2021)

Article Medicine, Research & Experimental

The Different Facets of Liquid Biopsy: A Kaleidoscopic View

Zahra Eslami-S et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2020)

Editorial Material Multidisciplinary Sciences

Perspective: The future of liquid biopsy

Catherine Alix-Panabieres

NATURE (2020)

Article Biochemistry & Molecular Biology

Noninvasive Early Identification of Therapeutic Benefit from Immune Checkpoint Inhibition

Barzin Y. Nabet et al.

Article Medicine, General & Internal

Atezolizumab for First-Line Treatment of PD-L1-Selected Patients with NSCLC

Roy S. Herbst et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Oncology

International liquid biopsy standardization alliance white paper

Dana Connors et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

Article Medicine, General & Internal

Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer

M. D. Hellmann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Oncology

Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA

Sarah B. Goldberg et al.

CLINICAL CANCER RESEARCH (2018)

Article Multidisciplinary Sciences

Evaluation of PD-L1 expression on vortex-isolated circulating tumor cells in metastatic lung cancer

Manjima Dhar et al.

SCIENTIFIC REPORTS (2018)

Review Medicine, General & Internal

Application of Cell-free DNA Analysis to Cancer Treatment

Ryan B. Corcoran et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer

Martin Reck et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Oncology

Frequent expression of PD-L1 on circulating breast cancer cells

Martine Mazel et al.

MOLECULAR ONCOLOGY (2015)

Article Medicine, General & Internal

Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer

H. Borghaei et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)