Diagnostic value of Serum Amyloid A, Interleukin-6 in gravidas with spontaneous preterm birth

Purpose: Spontaneous preterm birth (SPB) can't be predicted accurately nowadays. We aim to investigate the value of serum amyloid A(SAA) and interleukin-6(IL-6) for forecasting the risk of SPB. Methods: A total of 302 pregnant women who completed delivery in our hospital from January 2019 to December 2021 were included. According to gestational days, they were divided into the case group (28-33(+6) weeks, 41 cases; 34-36(+6) weeks, 96 cases) and the control group (37-42 weeks, 165 cases). The general data of the two groups were analyzed and the values of SAA and IL-6 in speculating the risk of SPB were studied in this study. Results: The levels of SAA and IL-6 in the case group were higher than those in the control group(P < 0.05), and the most practical value of SAA and IL-6 access SPB risk were 17.35 mg/L, 112.41 pg/mL respectively. The area under the ROC curve of diagnosis to predict SPB were 0.8849, 0.8664. Conclusions: The assessment of SPB risk by SAA and IL-6 bearscertain clinical value, which could assist clinicians in recognizing and evaluating the potential dangers of SPB.

Automated summary

The study aimed to investigate the value of serum amyloid A (SAA) and interleukin-6 (IL-6) in predicting the risk of spontaneous preterm birth (SPB). The results showed that the levels of SAA and IL-6 were higher in the SPB case group compared to the control group and had good predictive value for SPB risk.