Design of portable electrochemiluminescence sensing systems for point-of-care-testing applications

Point-of-care testing (POCT) technology is highly desirable for clinical diagnosis, healthcare monitoring, food safety inspection, and environment surveillance, because it enables rapid detection anywhere, any-time, and by anyone. Electrochemiluminescence (ECL) has been widely used in chemo-/bio analysis due to its advantages such as high sensitivity, simplicity, rapidity and easy to control, and is now attracting increasing attention for POCT applications. However, to realize the accurate on-site quantitation, it is still challenging to develop portable devices which can precisely collect, analyze, transmit and display the ECL signals. This review will focus on how to develop a portable ECL device by summarizing recent examples and analyzing their key components part by part. Then the possible solutions to the existing challenges in the development and applications of portable ECL devices are summarized and discussed in detail, followed by offering future perspectives. We attempted to provide an appealing viewpoint to inspire in-terested researchers to comprehend and explore portable ECL sensing systems for practical applications and even commercialization.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

POCT technology is highly desirable for various applications, and electrochemiluminescence (ECL) is a promising method due to its advantages. However, developing portable ECL devices that can accurately quantify on-site remains challenging. This review focuses on summarizing recent examples of portable ECL devices and analyzing their key components, discussing the challenges and potential solutions, and providing future perspectives.