4.7 Article

Difenoconazole causes cardiotoxicity in common carp (Cyprinus carpio): Involvement of oxidative stress, inflammation, apoptosis and autophagy

Related references

Note: Only part of the references are listed.
Article Environmental Sciences

DNA damage and cell apoptosis induced by fungicide difenoconazole in mouse mononuclear macrophage RAW264.7

Ruirui Li et al.

Summary: The study revealed the cytotoxic effect of fungicide DFC on mouse monocyte macrophage RAW264.7, including inhibiting cell viability, inducing DNA damage, and enhancing apoptosis.

ENVIRONMENTAL TOXICOLOGY (2022)

Article Environmental Sciences

Microplastics reduce the bioaccumulation and oxidative stress damage of triazole fungicides in fish

Changsheng Li et al.

Summary: The study investigated the single and combined effects of polystyrene microplastics (PS-MPs) and the triazole fungicide difenoconazole on zebrafish. It was found that PS-MPs reduced the bioaccumulation of difenoconazole in zebrafish and alleviated oxidative stress damage in the liver. Transcriptome and qRT-PCR data revealed the association of multiple pathways in difenoconazole response, with the presence of PS-MPs ameliorating gene expression changes.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Article Environmental Sciences

Sub-Chronic Difenoconazole Exposure Induced Gut Microbiota Dysbiosis in Mice

Zhiwei Bao et al.

Summary: The study revealed that exposure to DIF significantly impacted the mucus barrier and gut microbiota composition in mice, leading to changes in mucin protein expression and microbial diversity over time.

TOXICS (2022)

Article Environmental Sciences

Difenoconazole causes spleen tissue damage and immune dysfunction of carp through oxidative stress and apoptosis

Feixue Liu et al.

Summary: With the increasing use of pesticides, there is a growing concern about the levels of residual pesticides in the aquatic environment and their impact on non-target organisms. This study focused on the acute toxic effects of difenoconazole (DFZ), a class of long-lasting fungicides, on the spleen tissue of carp. The results showed that DFZ caused severe histopathology, apoptosis, oxidative stress, and inflammation in the spleen tissue of carp, leading to tissue damage. These findings highlight the importance of ensuring the safety of aquatic organisms in pesticide usage.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Article Environmental Sciences

Gestational exposure to tebuconazole affects the development of rat fetal Leydig cells

Feifei Ma et al.

Summary: Exposure to tebuconazole in utero causes the proliferation of fetal Leydig cells, possibly through effects on cell autophagy and proliferation mechanisms.

CHEMOSPHERE (2021)

Article Environmental Sciences

The heart of the adult goldfish Carassius auratus as a target of Bisphenol A: a multifaceted analysis

Mariacristina Filice et al.

Summary: In this study, the effects of in vivo exposure to BPA on the heart physiology, morphology, and oxidative balance in goldfish were investigated. High concentrations of BPA negatively affected cardiac hemodynamics and resulted in structural changes in the myocardium. The findings suggest that BPA may induce deleterious morpho-functional alterations in the adult goldfish heart in a time- and concentration-dependent manner.

ENVIRONMENTAL POLLUTION (2021)

Article Environmental Sciences

Difenoconazole induces oxidative DNA damage and mitochondria mediated apoptosis in SH-SY5Y cells

Xin Wang et al.

Summary: Difenoconazole exhibits neurotoxicity at the cellular level, causing cell apoptosis and DNA damage, and adversely affecting cell function.

CHEMOSPHERE (2021)

Article Environmental Sciences

The effects of fipronil exposure on oxidative stress, non-specific immunity, autophagy, and apoptosis in the common carp

Jianjun Chen et al.

Summary: The study evaluated the effect of fipronil on the immune response, oxidative stress, autophagy, and apoptosis in carp. Results showed significant changes in various parameters in carp exposed to fipronil, with increased impact with longer exposure times. The findings suggest that fipronil could potentially harm carp and should be used cautiously to protect aquatic ecosystems.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

Article Immunology

Vibrio alginolyticus Triggers Inflammatory Response in Mouse Peritoneal Macrophages via Activation of NLRP3 Inflammasome

Jinxin Wang et al.

Summary: The study demonstrates the significant role of the NLRP3 pathway in V. alginolyticus-triggered inflammatory response in mouse peritoneal macrophages, with the inhibition of NLRP3 alleviating the inflammation.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Plant Sciences

Fungicide Difenoconazole Induced Biochemical and Developmental Toxicity in Wheat (Triticum aestivum L.)

Runqiang Liu et al.

Summary: Difenoconazole exposure inhibits plant growth by reducing root and shoot development, decreasing chlorophyll biosynthesis, and inducing oxidative stress, ultimately leading to impaired wheat plant growth and development.

PLANTS-BASEL (2021)

Review Biochemistry & Molecular Biology

Regulation of Cancer Metastasis by TRAIL/Death Receptor Signaling

You-Take Oh et al.

Summary: The involvement of the TRAIL/death receptor signaling pathway in the regulation of cancer invasion and metastasis is complex, with both positive and negative roles reported. The underlying molecular mechanisms are even more complicated. This review focuses on discussing the current understanding of how TRAIL/death receptor-mediated signaling regulates cancer cell invasion and metastasis.

BIOMOLECULES (2021)

Article Environmental Sciences

Difenoconazole induces cardiovascular toxicity through oxidative stress-mediated apoptosis in early life stages of zebrafish (Danio rerio)

Jiansheng Zhu et al.

Summary: The study found that DIF induced cardiovascular toxicity in zebrafish embryos, resulting in decreased hatching rate, survival rate, heart rate, and increased malformation rate. DIF exacerbated oxidative stress, triggering cardiovascular apoptosis and inhibiting cardiac muscle contraction, which could be restored by the antioxidant N-acetyl-L-cysteine (NAC).

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Food Science & Technology

Three widely used pesticides and their mixtures induced cytotoxicity and apoptosis through the ROS-related caspase pathway in HepG2 cells

Tiancai Wang et al.

Summary: The study found that Difenoconazole, cypermethrin, and triazophos exhibit cytotoxicity and induce apoptosis in human hepatocellular carcinoma cells. Mixtures of these pesticides showed stronger toxic effects on cells compared to individual pesticides.

FOOD AND CHEMICAL TOXICOLOGY (2021)

Article Engineering, Environmental

Degradation of difenoconazole in water and soil: Kinetics, degradation pathways, transformation products identification and ecotoxicity assessment

Yanli Man et al.

Summary: The laboratory experiments revealed that difenoconazole undergoes oxidation, dechlorination, and hydroxylation reactions in the environment, leading to the formation of various transformation products. Four novel transformation products showed lower acute toxicity compared to difenoconazole, but were predicted to be chronically very toxic to fish, posing a potential threat to aquatic ecosystems.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Environmental Sciences

Oxidative stress induced by ultrafine carbon black particles can elicit apoptosis in vivo and vitro

Yanting Li et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article

Apoptosis (programmed cell death) and its signals - A review

E. Obeng

BRAZILIAN JOURNAL OF BIOLOGY (2020)

Review Cell Biology

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

Mark S. D'Arcy

CELL BIOLOGY INTERNATIONAL (2019)

Review Biochemistry & Molecular Biology

Autophagy-dependent cell death

Donna Denton et al.

CELL DEATH AND DIFFERENTIATION (2019)

Article Environmental Sciences

Developmental toxicity of penconazole in Zebrfish (Danio rerio) embryos

Feyza Icoglu Aksakal et al.

CHEMOSPHERE (2018)

Review Biochemistry & Molecular Biology

Transcriptional Regulation by Nrf2

Claudia Tonelli et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Review Biochemistry & Molecular Biology

Computer-Aided Targeting of the PI3K/Akt/mTOR Pathway: Toxicity Reduction and Therapeutic Opportunities

Tan Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Review Biochemistry & Molecular Biology

Autophagy: Renovation of Cells and Tissues

Noboru Mizushima et al.

Article Engineering, Environmental

Effects of Pesticides Monitored with Three Sampling Methods in 24 Sites on Macroinvertebrates and Microorganisms

Ralf B. Schaefer et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2011)

Review Biochemistry & Molecular Biology

The role of mitochondria in apoptosis

Seon-Yong Jeong et al.

BMB REPORTS (2008)

Article Biochemistry & Molecular Biology

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

O Micheau et al.

Article Plant Sciences

Antioxidants, oxidative damage and oxygen deprivation stress: a review

O Blokhina et al.

ANNALS OF BOTANY (2003)

Article Cardiac & Cardiovascular Systems

Oxidative stress and apoptosis in heart dysfunction

D Kumar et al.

Review Biochemistry & Molecular Biology

The physiological role of the creatine kinase system: Evolution of views

TY Lipskaya

BIOCHEMISTRY-MOSCOW (2001)