Ultrasensitive electrochemical sensor for the detection of carbamazepine based on gadolinium vanadate nanostructure decorated functionalized carbon nanofiber nanocomposite

The gadolinium vanadate nanostructure decorated functionalized carbon nanofiber (GdVO4/f-CNF) nanocomposite was prepared by the hydrothermal method, which is fabricated on a glassy carbon electrode (GCE) for the determination of carbamazepine (CBZ). The structural morphology of the hydrothermally synthesized GdVO4/f-CNF material was investigated by several spectroscopy methods such as FESEM, HRTEM, EDS-mapping, XRD, XPS, and Raman. Moreover, the electrical conductivity of our synthesized material was inspected by the electrochemical impedance spectroscopy (EIS) analysis, and the electrochemical performance towards CBZ was inspected by the cyclic voltammetry (CV) and amperometry (AMP) analysis under optimized conditions. The AMP determination of CBZ exhibits the lowest level LOD of 0.0018 mu M and a good linear range of 0.01-157 mu M. Additionally, our proposed sensor was used to determine the CBZ in the pharmaceutical and, human urine samples which have exposed the acceptable recoveries.

Automated summary

The gadolinium vanadate nanostructure decorated functionalized carbon nanofiber (GdVO4/f-CNF) nanocomposite was prepared using the hydrothermal method and fabricated on a glassy carbon electrode (GCE) for the determination of carbamazepine (CBZ). The structural morphology of the synthesized material was characterized using various spectroscopy methods, and its electrical conductivity and electrochemical performance towards CBZ were assessed. The nanocomposite exhibited a low LOD and a wide linear range for AMP determination of CBZ. The proposed sensor showed acceptable recoveries in pharmaceutical and human urine samples.