Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 17, Issue 20, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202200628
Keywords
boronate ester; dynamic covalent; hydrogel; polymers; supramolecular chemistry
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Funding
- IAF-PP (A*STAR, HMBS Domain) [H20C6a0033]
- National Research Foundation Investigatorship [NRFI07-2021-0021]
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A supramolecular hydrogel system was prepared by forming dynamic covalent crosslinks between 4-carboxyphenylboronic acid (CPBA) and polyvinyl alcohol (PVA). The hydrogel system was further crosslinked with either calcium ions or branched polyethylenimine (PEI) to generate hydrogels with different properties.
Supramolecular hydrogels have attracted considerable interest due to their unique stimuli-responsive and self-healing properties. However, these hydrogel systems are usually achieved by covalent grafting of supramolecular units onto the polymer backbone, which in turn limits their reprocessability. Herein, we prepared a supramolecular hydrogel system by forming dynamic covalent crosslinks between 4-carboxyphenylboronic acid (CPBA) and polyvinyl alcohol (PVA). The system was then further crosslinked with either calcium ions or branched polyethylenimine (PEI) to generate hydrogels with distinctly different properties. Incorporation of calcium ions resulted in the formation of hydrogels with higher storage modulus of 7290 Pa but without self-healing properties. On the other hand, PEI-crosslinked hydrogel (PVA-CPBA-PEI) exhibited >2000% critical strain value, demonstrated high stability over 52 days and showed sustained antibacterial effect. A combination of supramolecular interactions and dynamic covalent crosslinks can be an alternate strategy to fabricate next-generation hydrogel materials.
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