Synthesis of Chiral α-Substituted β-Aminophosphine Derivatives through Asymmetric Hydrophosphinylation Utilizing Secondary Phosphine Sulfides

The organocatalytic enantioselective hydrophosphinylation of various secondary phosphine sulfides with aromatic and aliphatic nitroalkenes is presented in this study. The reaction produced chiral 13-nitrophosphine sulfides with excellent yields and enantioselectivities (up to 99% yield and 99% ee). Furthermore, the chiral beta-nitrophosphine sulfides can be easily converted into alpha-substituted beta-aminophosphine, which is a family of useful P, N-ligands and phosphine catalysts.

Automated summary

This study presents an efficient organocatalytic method for the enantioselective hydrophosphinylation of various phosphine sulfides with aromatic and aliphatic nitroalkenes, resulting in chiral 13-nitrophosphine sulfides with high yields and enantioselectivities. Furthermore, the chiral beta-nitrophosphine sulfides can be easily converted into useful P, N-ligands and phosphine catalysts.