4.6 Article

Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

The Pseudo-Natural Product Rhonin Targets RHOGDI

Mohammad Akbarzadeh et al.

Summary: This study combines biological relevance and fragment-based design to discover novel compounds with potential new biological targets. Through synthesizing pseudo-natural products, a first small-molecule ligand of RHOGDI1 was identified.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Review Chemistry, Multidisciplinary

Chemical Evolution of Natural Product Structure

Michael Grigalunas et al.

Summary: This article introduces the concept, design, and development workflow of pseudo-natural products, and discusses their relationship with natural products and cheminformatic analysis.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Review Chemistry, Multidisciplinary

Ketones as strategic building blocks for the synthesis of natural product-inspired compounds

Daniel J. Foley et al.

Summary: Natural product-inspired compound collections are important sources for discovering new bioactive compounds for treating diseases. Ketones, with their variety of synthetic transformations, prevalence as commercial building blocks, and relative ease of synthesis, can be valuable as starting materials for the synthesis of natural product-inspired compounds. This review explores the use of ketones as general precursors and summarizes the synthetic transformations available for the annulation of natural product ring-systems to ketone starting materials.

CHEMICAL SOCIETY REVIEWS (2022)

Article Chemistry, Multidisciplinary

Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol-Inspired Compound Collection

Thomas Whitmarsh-Everiss et al.

Summary: This study identified potent and selective inhibitors of cholesterol transport proteins through the synthesis of a diverse sterol-inspired compound collection, demonstrating a general strategy for future applications. The strategy may be applicable to other therapeutically relevant sterol-binding proteins.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Medicinal

Pseudonatural Products Occur Frequently in Biologically Relevant Compounds

Jose-Manuel Gally et al.

Summary: This study introduces a new methodology for classifying fragment combinations and characterizing pseudonatural products using Python package. By analyzing the pairwise relative position of fragments within molecules, 18 different possible fragment combination categories were identified. Comparison with natural product references revealed that approximately 23% of biologically relevant compounds in the database comply with the PNP definition.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2021)

Review Chemistry, Multidisciplinary

Pseudo Natural Products-Chemical Evolution of Natural Product Structure

George Karageorgis et al.

Summary: PNPs are compounds formed by combining NP fragments in unique ways, inheriting important biological characteristics of NPs while exhibiting unprecedented bioactivity. The importance of design principles, synthesis, and biological research on PNP scaffolds is emphasized. PNPs are considered as a human-driven branch of the evolution of natural product structure.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Multidisciplinary Sciences

Natural product fragment combination to performance-diverse pseudo-natural products

Michael Grigalunas et al.

Summary: Natural product structure and fragment-based compound development inspire the design of pseudo-natural products through combinations of fragments to create chemically and biologically diverse compound classes. A library of 244 pseudo-natural products was synthesized and evaluated in cell painting essays, revealing the phenotypic role of individual fragments in determining bioactivity.

NATURE COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

Combination of Pseudo-Natural Product Design and Formal Natural Product Ring Distortion Yields Stereochemically and Biologically Diverse Pseudo-Sesquiterpenoid Alkaloids

Jie Liu et al.

Summary: This study describes the synthesis and biological evaluation of a new compound class inspired by natural products, combining the pseudo-natural product design strategy and ring distortion approach. The resulting pseudo-sesquiterpenoid alkaloids are chemically and biologically diverse, with their biological performance dependent on the structure of sesquiterpene lactone-derived scaffolds and the stereochemistry of pyrrolidine fragments. The compound collection led to the discovery of a novel chemotype inhibiting Hedgehog-dependent osteoblast differentiation.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Multidisciplinary

Synthesis of Indofulvin Pseudo-Natural Products Yields a New Autophagy Inhibitor Chemotype

Annina Burhop et al.

Summary: By combining fragments derived from natural products in new ways, a collection of pseudo-NPs known as indofulvins has been created. These compounds define a new chemotype of autophagy inhibitors targeting mitochondrial respiration, showing potential pharmacological properties.

ADVANCED SCIENCE (2021)

Article Chemistry, Multidisciplinary

Phenotyping Reveals Targets of a Pseudo-Natural-Product Autophagy Inhibitor

Daniel J. Foley et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Principle and design of pseudo-natural products

George Karageorgis et al.

NATURE CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Pseudo-natural products and natural product-inspired methods in chemical biology and drug discovery

Michael Grigalunas et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2020)

Article Chemistry, Medicinal

Opportunities for Tapping into Three-Dimensional Chemical Space through a Quaternary Carbon

Tanaji T. Talele

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Re-engineering natural products to engage new biological targets

Stephen E. Motika et al.

NATURAL PRODUCT REPORTS (2020)

Article Biochemistry & Molecular Biology

Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor

Micael Rodrigues Cunha et al.

RSC MEDICINAL CHEMISTRY (2020)

Review Chemistry, Medicinal

State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures

Christian Espinosa-Bustos et al.

FUTURE MEDICINAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Swiss Target Prediction: updated data and new features for efficient prediction of protein targets of small molecules

Antoine Daina et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Chemistry, Multidisciplinary

Design, Synthesis, and Phenotypic Profiling of Pyrano-Furo-Pyridone Pseudo Natural Products

Andreas Christoforow et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Chemistry, Multidisciplinary

Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and-3

Javier Ceballos et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Chemistry, Multidisciplinary

Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIβ

Lea Kremer et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Chemistry, Organic

Guided by Evolution: Biology-Oriented Synthesis of Bioactive Compound Classes

George Karageorgis et al.

SYNTHESIS-STUTTGART (2019)

Article Biochemistry & Molecular Biology

The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype

Tabea Schneidewind et al.

CELL CHEMICAL BIOLOGY (2019)

Article Chemistry, Multidisciplinary

Charting Biologically Relevant Spirocyclic Compound Space

Gerhard Mueller et al.

CHEMISTRY-A EUROPEAN JOURNAL (2017)

Article Chemistry, Multidisciplinary

Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell-based Compound Discovery and Target Prediction

Lea Kremer et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Review Biochemistry & Molecular Biology

Hedgehog Signaling: From Basic Biology to Cancer Therapy

Fujia Wu et al.

CELL CHEMICAL BIOLOGY (2017)

Review Chemistry, Medicinal

Recent advances of chroman-4-one derivatives: Synthetic approaches and bioactivities

Saeed Emami et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Review Chemistry, Multidisciplinary

The Chemistry of Griseofulvin

Asger B. Petersen et al.

CHEMICAL REVIEWS (2014)

Article Chemistry, Multidisciplinary

Biology-Oriented Synthesis: Harnessing the Power of Evolution

Hilde van Hattum et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Review Biochemistry & Molecular Biology

Natural products as starting points for the synthesis of complex and diverse compounds

Karen C. Morrison et al.

NATURAL PRODUCT REPORTS (2014)

Article Chemistry, Multidisciplinary

Natural-product-derived fragments for fragment-based ligand discovery

Bjoern Over et al.

NATURE CHEMISTRY (2013)

Review Cell Biology

The mechanisms of Hedgehog signalling and its roles in development and disease

James Briscoe et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Review Chemistry, Multidisciplinary

Biology-Oriented Synthesis

Stefan Wetzel et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Review Cell Biology

Gli Proteins in Development and Disease

Chi-chung Hui et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)

Review Chemistry, Medicinal

Small-Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics

Stefan Peukert et al.

CHEMMEDCHEM (2010)

Review Biotechnology & Applied Microbiology

Biosynthesis and biotechnological production of flavanones: current state and perspectives

Zachary L. Fowler et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2009)

Article Chemistry, Medicinal

Natural product-likeness score and its application for prioritization of compound libraries

Peter Ertl et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2008)

Article Biotechnology & Applied Microbiology

Relating protein pharmacology by ligand chemistry

Michael J. Keiser et al.

NATURE BIOTECHNOLOGY (2007)

Article Chemistry, Medicinal

Novel procedure for modeling ligand/receptor induced fit effects

W Sherman et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Use of an induced fit receptor structure in virtual screening

W Sherman et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2006)

Article Biochemistry & Molecular Biology

Purmorphamine activates the Hedgehog pathway by targeting Smoothened

S Sinha et al.

NATURE CHEMICAL BIOLOGY (2006)

Article Multidisciplinary Sciences

Kinetic suppression of microtubule dynamic instability by griseofulvin: Implications for its possible use in the treatment of cancer

D Panda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway

X Wu et al.

CHEMISTRY & BIOLOGY (2004)

Review Chemistry, Multidisciplinary

Natural product hybrids as new leads for drug discovery

LF Tietze et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)