Journal
CHEMISTRY & BIODIVERSITY
Volume 19, Issue 12, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202200343
Keywords
Myristica malabarica; malabaricones; isolation and characterization by single crystal XRD and 2D NMR; anti-proliferative activity
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Phytochemical investigation of the methanol extract of Myristica malabarica fruit rind led to the isolation of eight known compounds. In vitro assay showed that these compounds exhibited moderate anti-proliferative activity against human ovarian cancer cells.
Phytochemical investigation of the methanol extract of the fruit rind of Myristica malabarica led to the isolation of eight known compounds that were identified as malabaricones A-D, promalabaricones B and C, 1-(2,6-dihydroxyphenyl)tetradecan-1-one, and ericanone by comparison with literature spectroscopic data. The structures of malabaricones A-D, promalabaricone B, and 1-(2,6-dihydroxyphenyl)tetradecan-1-one were confirmed by X-ray crystallography. In vitro assay of the isolated phenols indicated that they exhibited moderate anti-proliferative activity against the A2780 human ovarian cancer cell. Compounds (1, 3, 5, 6 and 7) had the most potent activities, whereas the anti-proliferative activities of compounds 2 and 4 were less potent.
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