4.5 Review

Synthetic and Medicinal Perspective of 1,2,4-Triazole as Anticancer Agents

Related references

Note: Only part of the references are listed.
Review Chemistry, Physical

Synthetic and medicinal perspective of antileishmanial agents: An overview

Swati Pawar et al.

Summary: Leishmaniasis is a common neglected tropical disease that affects over 98 countries and millions of people each year. It poses severe risks to the genetic inheritance and host immunity of over one billion individuals. Currently, there is no specific treatment available, thus there is an urgent need for novel therapies. This review presents the synthesis of various compounds that show great potential against leishmaniasis and its causative species, providing insights for new drug development.

JOURNAL OF MOLECULAR STRUCTURE (2023)

Review Chemistry, Medicinal

The Antibacterial Activity of 1,2,3-triazole- and 1,2,4-Triazole-containing Hybrids against Staphylococcus aureus: An Updated Review (2020-Present)

Jie Li et al.

Summary: This review provides an update on the latest developments of 1,2,3-triazole and 1,2,4-triazole-containing hybrids with anti-S. aureus activity.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2022)

Review Chemistry, Medicinal

Synthesis and Clinical Development of Palbociclib: An Overview

Debabrata Konar et al.

Summary: Breast cancer is the second most common cancer in women in the United States, with increasing cases of patients developing resistance to traditional therapies. Palbociclib, a novel drug targeting CDK4 and CDK6, has been granted accelerated approval by the FDA for combination therapy in postmenopausal women with ER+, HER2- metastatic breast cancer, highlighting the need for new treatments in advanced breast cancer and resistance.

MEDICINAL CHEMISTRY (2022)

Review Chemistry, Organic

Microwave-assisted diversified synthesis of pyrimidines: An overview

Kapil Kumar

Summary: Pyrimidines and their hybrid molecules have been favored by organic chemists for their richness in natural and synthetic compounds, with microwave-assisted synthetic protocols playing a significant role in construction. In recent years, solid-supported protocols and ionic liquid-catalyzed strategies have been utilized for the synthesis of pyrimidine and its derivatives, showing excellent yield and adherence to green chemistry principles. Additionally, microwave-irradiated approaches have been found to be more efficient compared to conventional methods, leading to better reaction time, yield, and atom economy.

JOURNAL OF HETEROCYCLIC CHEMISTRY (2022)

Review Biochemistry & Molecular Biology

Strategies for synthesis of 1,2,4-triazole-containing scaffolds using 3-amino-1,2,4-triazole

Shima Nasri et al.

Summary: Compounds containing 1,2,4-triazole scaffolds play a crucial role in drug discovery, this review article summarizes their pharmacological significance and synthesis strategies, encouraging further research to discover new drug candidates.

MOLECULAR DIVERSITY (2022)

Review Environmental Sciences

A comprehensive review of 1,2,4-triazole fungicide toxicity in zebrafish (Danio rerio): A mitochondrial and metabolic perspective

Tao Huang et al.

Summary: This critical review synthesizes peer-reviewed literature on triazole fungicide exposures in the zebrafish model. The data suggests that exposure to triazoles impairs mitochondrial function, oxidative stress, and lipid metabolism in zebrafish, leading to developmental delays, deformity, and aberrant behaviors. The review also identifies novel biomarkers of triazole fungicide exposure.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Review Chemistry, Medicinal

Antioxidant Activity of 1,2,4-Triazole and its Derivatives: A Mini-Review

Anna Pachuta-Stec

Summary: Free radicals, by-products of enzymatic reactions in the body, are involved in various diseases and aging processes. Antioxidants, both natural and synthetic, play a crucial role in neutralizing free radicals and maintaining a balance in the body. The search for new synthetic compounds with antioxidant properties is an important area of research in medicinal chemistry.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2022)

Review Chemistry, Medicinal

An Important Potential Anti-Epileptic/Anticonvulsant Active Group: A Review of 1,2,4-Triazole Groups and Their Action

Ying Wang et al.

Summary: The triazole compounds have significant importance in medicinal chemistry and play a key role in the design and development of anticonvulsant agents. They possess great research potential and value in the field of antiepileptic drugs.

DRUG RESEARCH (2022)

Review Chemistry, Multidisciplinary

Recent investigation on heterocycles with one nitrogen [piperidine, pyridine and quinoline], two nitrogen [1,3,4-thiadiazole and pyrazole] and three nitrogen [1,2,4-triazole]: a review

Zabiulla et al.

Summary: Heterocycles are the largest division in classical organic chemistry, with significant biological and industrial importance. They play a crucial role in pharmaceuticals, agrochemicals, and various industrial applications. The unique ability of heterocycles to display substituents around a core scaffold in defined three-dimensional representations has been exploited by the drug industry.

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY (2022)

Article Chemistry, Multidisciplinary

Synthesis of heterocyclic (triazole, furoxan, furazan) fused pyridazine di-N-oxides via hypervalent iodine oxidation

Qi Zhang et al.

Summary: A novel synthesis method for heterocyclic fused pyridazine di-N-oxides (triazole, furoxan, furazan) was described. The use of PIDA as a mild oxidant allowed for efficient synthesis of these motifs, solving the issues of harsh conditions and cumbersome manipulation in existing methods. Furthermore, the first synthesis of triazole fused pyridazine di-N-oxide provides a valuable building block for the preparation of biologically relevant molecules and energetic compounds.

NEW JOURNAL OF CHEMISTRY (2022)

Article Biochemistry & Molecular Biology

Molecular docking studies, biological evaluation and synthesis of novel 3-mercapto-1,2,4-triazole derivatives

Javad Ghanaat et al.

Summary: A series of new 3-mercapto-1,2,4-triazole derivatives were successfully synthesized in this study and screened for their anti-proliferative activity using MTT reduction assay, demonstrating significant cytotoxicity. Compounds with 3,4,5-trimethoxy moiety showed the highest activity against ovarian cancer cell line.

MOLECULAR DIVERSITY (2021)

Review Oncology

Synthetic and Medicinal Perspective of Fused-Thiazoles as Anticancer Agents

Swati Pawar et al.

Summary: Cancer is the second leading cause of human mortality after cardiovascular disease, with symptoms mainly depending on the specific type such as liver, lung, stomach, breast, and colon cancer being the most common. It is characterized by uncontrolled growth of malignant cells arising from abnormal growth in normal cells, resulting in a change in cell proliferation and differentiation mechanism.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2021)

Review Chemistry, Medicinal

1,2,4-Triazole hybrids with potential antibacterial activity against methicillin-resistantStaphylococcus aureus

Xuemei Ge et al.

Summary: MRSA, a significant pathogen in hospitals and communities, requires urgent development of novel antimicrobial agents. 1,2,4-triazole hybrids, with diverse mechanisms of antibacterial activity, exhibit broad-spectrum antibacterial activity against clinically important drug-resistant pathogens, including MRSA.

ARCHIV DER PHARMAZIE (2021)

Article Chemistry, Physical

Synthesis and anticancer activity of new spirooxindoles incorporating[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine moiety

Liangkun Ji et al.

Summary: A series of new spirooxindole derivatives were designed, synthesized, and characterized, with some compounds showing potent antiproliferative activities against cancer cell lines. Compound 4d, in particular, exhibited stronger activity compared to the positive control.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Article Chemistry, Medicinal

Synthesis and antitumor effects of a new class of 1,2,4-triazole derivatives

Zheng Wu et al.

Summary: The new class of 1,2,4-triazole derivatives bearing disulfide bond showed promising results as antitumor agents, with compounds 9e, 9g, and 10h displaying better cytotoxic activity on SMMC-7721 cells. These compounds also exhibited low cytotoxicity on normal cell line L929, making them potential candidates for further research in cancer treatment.

MEDICINAL CHEMISTRY RESEARCH (2021)

Article Biochemistry & Molecular Biology

Unravelling the anticancer potency of 1,2,4-triazole-N-arylamide hybrids through inhibition of STAT3: synthesis and in silico mechanistic studies

Abdallah Turky et al.

Summary: The study focused on the design, synthesis, pharmacokinetic profiles, and in vitro anticancer activity of novel C3-linked 1,2,4-triazole-N-arylamide hybrids for inhibition of STAT3. Four derivatives showed promising cytotoxic effects against selected cancer cells, with compound 12 exhibiting the highest potency. These compounds were analyzed for their potential as drug candidates based on their ADMET properties.

MOLECULAR DIVERSITY (2021)

Article Biochemistry & Molecular Biology

Probing phenylcarbamoylazinane-1,2,4-triazole amides derivatives as lipoxygenase inhibitors along with cytotoxic, ADME and molecular docking studies

Saima Muzaffar et al.

Summary: The study successfully synthesized a series of new derivatives with high inhibitory potential against 15-lipoxygenase, some of which also exhibited high cellular viability.

BIOORGANIC CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Design and synthesis of novel quinoline/chalcone/1,2,4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases

Aliaa M. Mohassab et al.

Summary: A series of new quinoline/chalcone hybrids containing 1,2,4-triazole moiety were designed and synthesized in this study, showing moderate to good activity against various cancer cell lines. Some of these compounds exhibited promising antiproliferative activities and displayed high binding affinities in inhibiting EGFR and BRAF(V600E) kinases.

BIOORGANIC CHEMISTRY (2021)

Review Chemistry, Medicinal

Synthetic and medicinal perspective of quinolines as antiviral agents

Ramandeep Kaur et al.

Summary: Quinoline scaffold plays a crucial role in medicinal agents, exhibiting useful biological activities such as anticancer and antibacterial properties. Despite various synthetic strategies developed worldwide, limitations such as side product formation and the use of expensive metal catalysts still exist, prompting ongoing efforts to develop efficient and cost-effective synthetic protocols.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Chemistry, Medicinal

A review: Pharmacological aspects of metal based 1,2,4-triazole derived Schiff bases

Wardha Zafar et al.

Summary: Clinical reports have emphasized the increasing threat of multidrug resistance due to antibiotic resistance. Research has shown that organic compounds now require metal ions for bio-transformation in order to enhance their potentiality against resistance. Metal based drugs have played an imperative role in developing new strategies with significant biological activity, safety, and efficacy. In recent years, metal based compounds have been of great interest for treating various diseases, filling the gap left by conventional methodologies.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Chemistry, Medicinal

Advances in the application of 1,2,4-triazole-containing hybrids as anti-tuberculosis agents

Yingdong Cao et al.

Summary: 1,2,4-triazole hybrids show promise as potential antitubercular agents, with the ability to enhance efficacy and reduce side effects through multiple mechanisms of action.

FUTURE MEDICINAL CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Design, Synthesis, Molecular Modeling, Anticancer Studies, and Density Functional Theory Calculations of 4-(1,2,4-Triazol-3-ylsulfanylmethyl)-1,2,3-triazole Derivatives

Adeeb Al Sheikh Ali et al.

Summary: New conjugates of 1,2,3-triazoles linked to 1,2,4-triazoles were synthesized and screened for anticancer activity against various cancer cell lines, showing promising results. The compounds with the highest potency demonstrated superior interactions with the target protein and exhibited significant anticancer activity. DFT calculations were performed to confirm the results of molecular docking and experimental findings.

ACS OMEGA (2021)

Article Chemistry, Multidisciplinary

Synthesis and Screening of New [1,3,4]Oxadiazole, [1,2,4]Triazole, and [1,2,4]Triazolo[4,3-b][1,2,4]triazole Derivatives as Potential Antitumor Agents on the Colon Carcinoma Cell Line (HCT-116)

El-sayed M. Abdelrehim

Summary: New derivatives of [1,3,4]oxadiazole-2-thione and triazole-3-thione were synthesized through various organic reactions. Screening results showed that some synthesized compounds exhibited cytotoxic activity against human colon carcinoma cancer cell lines.

ACS OMEGA (2021)

Article Chemistry, Medicinal

Synthesis and anticancer activity evaluation of naphthalene-substituted triazole spirodienones

Lan Luo et al.

Summary: The newly synthesized compound 6a has shown promising anticancer activity by inhibiting cell growth and inducing apoptosis in vitro, as well as suppressing tumor growth in vivo, indicating its potential as a future anticancer agent.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Medicinal

Discovery of [1,2,4]triazolo[1,5-a]pyrimidines derivatives as potential anticancer agents

Jin-Ling Huo et al.

Summary: Compound 6i showed potent anti-proliferative activity against MGC-803 with good safety in vivo. Mechanistic studies revealed that 6i induced apoptosis in MGC-803 cells through multiple pathways, suggesting its potential as a template for anti-cancer agents.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Medicinal

Design, synthesis and biological evaluation of imidazole and triazole-based carbamates as novel aromatase inhibitors

Alessandra Ammazzalorso et al.

Summary: Novel aromatase inhibitors based on triazole and imidazole-based carbamate derivatives were designed and synthesized, with compounds 13a and 15c showing dose-dependent inhibition of cell viability on the human breast cancer cell line MCF7. Docking simulations were also carried out to elucidate the binding modes of these active compounds to target human aromatase at a molecular level.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Organic

Recent advances in the chemistry of 1,2,4-triazoles: Synthesis, reactivity and biological activities

Abderrahmen Abdelli et al.

Summary: 1,2,4-Triazoles are important heterocyclic motifs widely present in molecular architectures with medicinal and pharmaceutical properties. This review focuses on synthetic approaches towards 1,2,4-triazole derivatives in the last decade and provides an overview of the biological properties of triazole derivatives in the last two years.

TETRAHEDRON LETTERS (2021)

Review Chemistry, Medicinal

1,2,4-Triazoles as Important Antibacterial Agents

Malgorzata Strzelecka et al.

Summary: Compounds containing the 1,2,4-triazole ring exhibit multidirectional biological activity and significant antibacterial properties, making them promising candidates for the development of novel antimicrobial agents to combat microbial resistance issues. Further research and rational design are needed to fully harness the potential of this scaffold.

PHARMACEUTICALS (2021)

Article Chemistry, Medicinal

Synthesis, biological evaluation, and structure-activity relationships of new tubulin polymerization inhibitors based on 5-amino-1,2,4-triazole scaffold

Fang Yang et al.

Summary: Thirty new 5-amino-1H-1,2,4-triazoles were synthesized and evaluated for antiproliferative activities, with compounds IIa, IIIh, and IIIm showing significant activity. Compound IIIm caused G2/M phase arrest in HeLa cells, while IIa exhibited the most potent tubulin polymerization inhibitory activity. Molecular modeling studies suggest that these compounds have potential for developing novel tubulin polymerization inhibitors with anticancer activity.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

Article Chemistry, Medicinal

Discovery of antiproliferative and anti-FAK inhibitory activity of 1,2,4-triazole derivatives containing acetamido carboxylic acid skeleton

Muhamad Mustafa et al.

Summary: Small molecule inhibitors of focal adhesion kinase have shown promising therapeutic potential in cancer treatment. Among the 1,2,4-triazole derivatives tested, compounds 3c and 3d demonstrated the strongest antiproliferative activity, with 3d being identified as a potent preclinical candidate for cancer treatment.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

Article Biochemistry & Molecular Biology

Antiproliferative activity, enzymatic inhibition and apoptosis-promoting effects of benzoxazole-based hybrids on human breast cancer cells

A-Mohsen M. E. Omar et al.

Summary: Novel benzoxazole derivatives were synthesized and evaluated for their anticancer activities, showing selectivity towards breast cancer cells and promising apoptosis-inducing properties. Compound 7a and 8e demonstrated potent inhibition of EGFR and ARO enzymes, highlighting their potential as anti-breast cancer agents.

BIOORGANIC CHEMISTRY (2021)

Article Chemistry, Medicinal

Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems

Ilenia Grieco et al.

Summary: Protein kinase CK1 delta plays a crucial role in various neuroinflammatory and neurodegenerative diseases, making it a potential therapeutic target. The development of ATP competitive inhibitors for CK1 delta, such as [1,2,4]triazolo[1,5-c]pyrimidines and [1,2,4]triazolo[1,5-a][1,3,5] triazines, represents a promising approach for future treatments. By identifying key interactions and structures, researchers aim to develop new inhibitors capable of crossing the blood-brain barrier for more effective treatment options.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Physical

Design, synthesis and biological evaluation of novel 5-(4-chlorophenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols as an anticancer agent

Krupa R. Patel et al.

Summary: The p53 protein is crucial for cancer prevention, and restoring p53 function through disrupting the p53-MDM2 interaction shows promise as a non-genotoxic anticancer therapeutic strategy. A novel series of molecules with a 1,2,4-triazole-3-thiol scaffold was successfully discovered, with some compounds exhibiting good inhibitory activity and one compound showing strong antitumor activity.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Review Chemistry, Organic

Recent Trends in the Chemistry of [1,2,4]Triazole[1,5-a]pyrimidines

Ashraf M. Mohamed et al.

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL (2021)

Article Chemistry, Multidisciplinary

Synthesis, Hemolytic Studies, and In Silico Modeling of Novel Acefylline-1,2,4-Triazole Hybrids as Potential Anti-cancer Agents against MCF-7 and A549

Irum Shahzadi et al.

Summary: A series of novel theophylline-7-acetic acid (acefylline)-derived 1,2,4-triazole hybrids with N-phenyl acetamide moieties were synthesized and tested for inhibitory potential against lung and breast cancer cell lines. Compound 11g showed the strongest inhibition with the lowest IC50 value and low cytotoxicity, and in silico modeling was carried out to confirm its binding mode in relation to its anti-cancer activity.

ACS OMEGA (2021)

Article Medicine, Research & Experimental

OMA1520 and OMA1774, novel 1,2,4-triazole bearing analogs of combretastatin A-4, inhibit hepatocellular carcinoma: Histological and immunohistochemical studies

Amany E. Nofal et al.

Summary: The study demonstrated that OMA1520 and OMA1774 have significant chemotherapeutic effects against HCC, reducing the cytotoxicity of MNU, restoring normal liver functions, and showing potential antioxidant properties. Co-administration of both analogs showed synergistic activity, suggesting they could be alternative anticancer agents.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Biochemistry & Molecular Biology

Discovery of novel celastrol-triazole derivatives with Hsp90-Cdc37 disruption to induce tumor cell apoptosis

Na Li et al.

Summary: Compound 6, designed to enhance the disruption of Hsp90-Cdc37, showed enhanced anti-proliferative activity on cancer cell lines, inhibited the expression of key clients, and induced tumor cell apoptosis. The compound's increased activity may be attributed to its enhanced covalent binding with thiols and ability to arrest cells in the G0/G1 phase. Further exploration of compound 6 for cancer treatment is warranted.

BIOORGANIC CHEMISTRY (2021)

Review Chemistry, Medicinal

The Medicinal Chemistry of 3-nitro-1,2,4-triazoles: Focus on Infectious Diseases

Rodolfo Rodrigo Florido Franca et al.

Summary: Infectious diseases are a major cause of death globally, particularly in developing countries. The pharmaceutical industry has historically shown little interest in developing new drugs for diseases such as tuberculosis, leishmaniasis, and Chagas disease, leaving many individuals reliant on ineffective treatments. Azole derivatives, particularly 3-nitro-1,2,4-triazoles, have shown promise in providing more effective and less toxic treatment options for these diseases through various mechanisms of action.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2021)

Article Chemistry, Medicinal

Identification of novel 1,3-diaryl-1,2,4-triazole-capped histone deacetylase 6 inhibitors with potential anti-gastric cancer activity

Xin-Hui Zhang et al.

Summary: In this study, a series of 1,3-diaryl-1,2,4-triazole-capped HDAC6 inhibitors were designed, synthesized and verified, with compound 9r showing the best inhibitory activity with potential for gastric cancer therapy. The high selectivity and affinity of 9r to HDAC6, along with its ability to upregulate acetylated alpha-tubulin levels and exhibit antiproliferative and anti-metastatic effects without significant toxicity, suggest that 9r could serve as a lead compound for the development of novel therapeutic agents for gastric cancer.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Synthesis of Biologically Relevant 1,2,3-and 1,3,4-Triazoles: From Classical Pathway to Green Chemistry

Lori Gonnet et al.

Summary: Green Chemistry has gained increasing research interest in the past two decades, with nonconventional methods such as microwave, mechanical mixing, visible light, and ultrasound being used for chemical reactions. 1,2,3-triazoles have significant applications in pharmaceutical chemistry, whereas their 1,2,4 counterparts are less developed. This review focuses on the synthesis of 1,2,3 and 1,2,4-triazole systems through classical and green chemistry conditions, emphasizing compounds/scaffolds with biological/pharmacophoric properties. Additionally, the formal cycloreversion of 1,2,3-triazole compounds under mechanical forces and their potential use in biological systems will be discussed.

MOLECULES (2021)

Review Chemistry, Organic

RECENT ADVANCES IN 1,2,4-TRIAZOLE RING CONSTRUCTION VIA CYCLOADDITION REACTIONS

Nataliya Korol et al.

Summary: This review article examines the sources that describe cycloaddition reactions leading to substituted 1,2,4-triazoles and their fused derivatives, covering literature data from 2011 to 2021. It highlights the synthetic particularities of cycloaddition products, optimization of reaction conditions, and factors influencing the direction of the reaction. Cycloaddition reactions are presented as a convenient method for obtaining functional 1,2,4-triazoles and their fused derivatives.

HETEROCYCLES (2021)

Article Multidisciplinary Sciences

Design, Synthesis, and Biological Evaluation of 1,2,4-Thiadiazole-1,2,4-Triazole Derivatives Bearing Amide Functionality as Anticancer Agents

Yazala Jyothsna Pragathi et al.

Summary: A novel library of amide compounds was designed and synthesized, with most showing moderate to potent anticancer activities against four different cancer cell lines. Certain synthesized compounds exhibited more potent activity than the standard drug, with inhibitory concentration values ranging from 0.10 +/- 0.084 to 11.5 +/- 6.49 μM.

ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING (2021)

Review Biochemistry & Molecular Biology

Structural and clinical impact of anti-allergy agents: An overview

Yagyesh Kapoor et al.

BIOORGANIC CHEMISTRY (2020)

Article Chemistry, Medicinal

NO-releasing STAT3 inhibitors suppress BRAF-mutant melanoma growth

Tamer S. Kaoud et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Chemistry, Medicinal

Recent Development of 1,2,4-triazole-containing Compounds as Anticancer Agents

Xiaoyue Wen et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2020)

Review Chemistry, Multidisciplinary

Exploring recent developments on 1,2,4-triazole: Synthesis and biological applications

Reshma Sathyanarayana et al.

JOURNAL OF THE CHINESE CHEMICAL SOCIETY (2020)

Review Chemistry, Medicinal

1,2,4-Triazole: A Privileged Scaffold for the Development of Potent Antifungal Agents - A Brief Review

Christophe Tratrat

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Design, synthesis, and cytotoxic screening of novel azole derivatives on hepatocellular carcinoma (HepG2 Cells)

Mohammed K. Abdelhameid et al.

BIOORGANIC CHEMISTRY (2020)

Review Chemistry, Organic

Fused bicyclic 1,2,4-triazoles with one extra sulfur atom: Synthesis, properties, and biological activity

Mikhailo V. Slivka et al.

JOURNAL OF HETEROCYCLIC CHEMISTRY (2020)

Article Chemistry, Medicinal

Discovery of new [1,2,4] Triazolo[1,5-a]Pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway

Shuai Wang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Chemistry, Multidisciplinary

TosMIC: A Powerful Synthon for Cyclization and Sulfonylation

Kapil Kumar

CHEMISTRYSELECT (2020)

Review Chemistry, Multidisciplinary

Recent Advances in 1,2,4-Triazole Scaffolds as Antiviral Agents

S. A. El-Sebaey

CHEMISTRYSELECT (2020)

Article Biochemistry & Molecular Biology

Novel 1,2,4-triazole derivatives as apoptotic inducers targeting p53: Synthesis and antiproliferative activity

Hesham A. M. Gomaa et al.

BIOORGANIC CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds

Oleksandr Grytsai et al.

BIOORGANIC CHEMISTRY (2020)

Review Chemistry, Medicinal

An insight on medicinal attributes of 1,2,4-triazoles

Ranjana Aggarwal et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Chemistry, Multidisciplinary

Two decades of the synthesis of mono- and bis-aminomercapto[1,2,4]triazoles

Sayed M. Riyadh et al.

RSC ADVANCES (2020)

Article Chemistry, Medicinal

Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction

Danqi Chen et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Identification of 1,2,4-triazoles as new thymidine phosphorylase inhibitors: Future anti-tumor drugs

Sohail Anjum Shahzad et al.

BIOORGANIC CHEMISTRY (2019)

Article Chemistry, Medicinal

Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors

Sonia Martinez-Gonzalez et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Chemistry, Organic

Diversity-Oriented Synthetic Approaches for Furoindoline: A Review

Ramandeep Kaur et al.

CURRENT ORGANIC SYNTHESIS (2019)

Article Chemistry, Organic

Diversified Synthetic Strategies for Pyrroloindoles: An Overview

Sundeep Kaur Manjal et al.

JOURNAL OF HETEROCYCLIC CHEMISTRY (2019)

Article Chemistry, Medicinal

Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study

Muhamad Mustafa et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Chemistry, Multidisciplinary

Synthesis and biological evaluation of 4-(1H-1,2,4-triazol-1-yl)benzoic acid hybrids as anticancer agents

Hatem A. Abuelizz et al.

RSC ADVANCES (2019)

Article Biochemistry & Molecular Biology

Synthesis, activity evaluation, and pro-apoptotic properties of novel 1,2,4-triazol-3-amine derivatives as potent anti-lung cancer agents

Xian-yu Sun et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2019)

Article Chemistry, Medicinal

1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of Na(v)1.7 inhibition

Alessandro A. Boezio et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Review Chemistry, Organic

Coumarin-triazole Hybrids and Their Biological Activities

Yi-Lei Fan et al.

JOURNAL OF HETEROCYCLIC CHEMISTRY (2018)

Article Chemistry, Organic

One-pot synthesis of [4-(tert-butyl)-1H-pyrrol-3-yl](phenyl)methanone from tosylmethyl isocyanide and carbonyl compound

Ramandeep Kaur et al.

CHEMISTRY OF HETEROCYCLIC COMPOUNDS (2018)

Review Chemistry, Medicinal

Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review

Ramandeep Kaur et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Chemistry, Organic

A Highly Stereoselective Chiral Auxiliary-assisted Reductive Cyclization to Furoindoline

Kapil Kumar et al.

JOURNAL OF HETEROCYCLIC CHEMISTRY (2017)

Article Chemistry, Medicinal

Design, Synthesis, Molecular Docking, and Anticancer Activity of Phthalazine Derivatives as VEGFR-2 Inhibitors

Abdel-Ghany A. El-Helby et al.

ARCHIV DER PHARMAZIE (2017)

Review Biochemistry & Molecular Biology

Synthetic and medicinal perspective of thiazolidinones: A review

Sundeep Kaur Manjal et al.

BIOORGANIC CHEMISTRY (2017)

Review Biochemistry & Molecular Biology

Recent synthetic and medicinal perspectives of tryptanthrin

Ramandeep Kaur et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2017)

Review Oncology

Recent Developments on 1,2,4-Triazole Nucleus in Anticancer Compounds: A Review

Ramandeep Kaur et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2016)

Article Chemistry, Medicinal

Synthetic and Medicinal Prospective of Structurally Modified Curcumins

Bhupinder Kumar et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)

Article Chemistry, Multidisciplinary

ZrCl4 Catalysed Diastereoselective Synthesis of Spirocarbocyclic Oxindoles via [4+2] Cycloaddition

Kapil Kumar et al.

CHEMISTRYSELECT (2016)

Article Chemistry, Multidisciplinary

Zirconocene dichloride catalysed one-pot synthesis of pyrroles through nitroalkene-enamine assembly

Sandeep Goyal et al.

RSC ADVANCES (2015)

Article Chemistry, Multidisciplinary

Lithium hydroxide mediated synthesis of 3,4-disubstituted pyrroles

Ratnesh Sharma et al.

RSC ADVANCES (2013)

Review Pharmacology & Pharmacy

Current targets for anticancer drug discovery

NH Nam et al.

CURRENT DRUG TARGETS (2003)