Zwitterionic Biomaterials

Article Engineering, Multidisciplinary

Fully Superhydrophilic, Self-Floatable, and Multi-Contamination-Resistant Solar Steam Generator Inspired by Seaweed

Chiyu Wen et al.

Summary: We have developed a seaweed-inspired, independently floatable superhydrophilic solar evaporator that can achieve continuous water pumping and heat concentration, and has anti-contamination and anti-fouling properties.

ENGINEERING (2023)

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Article Engineering, Mechanical

Biodegradable lubricating mesoporous silica nanoparticles for osteoarthritis therapy

Li Wan et al.

Summary: This study developed biodegradable lubricating drug-loaded nanoparticles for the treatment of osteoarthritis. The nanoparticles showed enhanced lubrication and sustained drug release behavior. The results suggest that these nanoparticles may be a promising approach for osteoarthritis therapy.

FRICTION (2022)

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Article Chemistry, Multidisciplinary

Fluorination and Betaine Modification Augment the Blood-Brain Barrier-Crossing Ability of Cylindrical Polymer Brushes

Ruonan Wang et al.

Summary: This study reports an exciting finding that fluorination and betaine modification can significantly enhance the blood-brain barrier (BBB)-crossing ability of cylindrical polymer brushes (CPBs).

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Engineering, Environmental

Self-healing polydimethylsiloxane antifouling coatings based on zwitterionic polyethylenimine-functionalized gallium nanodroplets

Baoluo He et al.

Summary: The study successfully developed PEIS modified GLM nanodroplets with potential applications in marine antifouling. These nanodroplets exhibit good antibacterial properties and antifouling performance.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Mechanical

Gelatin-based composite hydrogels with biomimetic lubrication and sustained drug release

Kuan Zhang et al.

Summary: The study successfully synthesized gelatin-based composite hydrogels with biomimetic lubrication and sustained drug release properties, which showed good biocompatibility and effective protection of chondrocytes from inflammatory damage.

FRICTION (2022)

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Article Chemistry, Multidisciplinary

A Safe, Fibrosis-Mitigating, and Scalable Encapsulation Device Supports Long-Term Function of Insulin-Producing Cells

Wanjun Liu et al.

Summary: The study introduces a durable and safe nanofibrous device coated with a fibrosis-mitigating hydrogel for encapsulation of islets and SC-beta cells, supporting long-term cell engraftment without significant fibrotic reactions. The scalability and retrievability of the device in dogs further demonstrate its potential for cell therapies to treat T1D and other diseases, with successful correction of diabetes in animal models for extended periods of time.

SMALL (2022)

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Article Engineering, Biomedical

Transepithelial delivery of insulin conjugated with phospholipid-mimicking polymers via biomembrane fusion-me diate d transcellular pathways

Hiroaki Hatano et al.

Summary: This study demonstrates the energy independent permeation of a water-soluble phospholipid-mimicking random copolymer through epithelial barriers, as well as the successful transepithelial delivery of insulin while maintaining its bioactivity. These findings are significant for the development of efficient and safe transepithelial drug delivery systems.

ACTA BIOMATERIALIA (2022)

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Article Polymer Science

Antifouling and antibacterial zwitterionic hydrogels as soft contact lens against ocular bacterial infections

Jing Zhang et al.

Summary: Antifouling and antibacterial zwitterionic hydrogels were developed as soft contact lens for ocular bacterial infection therapy. These hydrogels exhibit high transmittance, water content, water retention rate, and antifouling properties. They can also load and control the release of drugs, demonstrating significant antibacterial effects in vitro and in vivo.

EUROPEAN POLYMER JOURNAL (2022)

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Article Engineering, Chemical

Construction of electro-neutral surface on dialysis membrane for improved toxin clearance and anti-coagulation/inflammation through saltwater fish inspired trimethylamine N-oxide (TMAO)

Yang Liu et al.

Summary: The study demonstrated that modifying the surface of Polysulfone membranes with trimethylamine N-oxide (TMAO) could improve hemocompatibility and toxin clearance, effectively preventing coagulation and inflammation reactions.

JOURNAL OF MEMBRANE SCIENCE (2022)

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Article Engineering, Chemical

Cell-friendly regulation of ice crystals by antifreeze organism-inspired materials

Jing Yang et al.

Summary: In this study, different types of antifreeze organism-inspired ICMs were designed to regulate ice crystals and provide cell-friendly protection. This protection mechanism can effectively improve the efficiency of cryopreservation and further support cell-based therapies.

AICHE JOURNAL (2022)

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Article Biochemical Research Methods

Impacts of a Zwitterionic Peptide on its Fusion Protein

Patrick McMullen et al.

Summary: Modifying therapeutic proteins with high-molecular-weight molecules like EKP can improve their pharmacokinetic properties. However, it is important to assess the impact of EKP on structural behavior and receptor binding of the modified protein. Through yeast display and computational modeling, this study shows that EKP does not hinder receptor binding or alter the structural behavior of GCSF. Moreover, the EKP-GCSF fusion protein demonstrates improved pharmacokinetics and prolonged bioactivity in vivo.

BIOCONJUGATE CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Motif-based zwitterionic peptides impact their structure and immunogenicity

Patrick McMullen et al.

Summary: This study investigates the immunogenicity of EK peptides and identifies different sequence motifs with varying immunogenicity. Computational modeling and experimental results demonstrate a link between charge imbalance and peptide immunogenicity.

CHEMICAL SCIENCE (2022)

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Review Chemistry, Multidisciplinary

Dealing with the Foreign-Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Donghui Zhang et al.

Summary: This review introduces the issue of foreign-body response caused by implanted biomaterials and strategies to resist it. It focuses on three promising foreign-body response resisting materials, discussing their advantages, characteristics, and applications, and suggests future development prospects and current challenges.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Engineering, Environmental

Hypoxia-degradable zwitterionic phosphorylcholine drug nanogel for enhanced drug delivery to glioblastoma

Dejun She et al.

Summary: In this study, a hypoxia-degradable zwitterionic phosphorylcholine nanogels (PMPC)-P-H was developed for enhanced chemotherapy of glioblastoma. The nanogels exhibited favorable biocompatibility, long-circulating property, and the ability to pass through the blood-brain barrier effectively, leading to long-lasting accumulation in glioblastoma tissue and fast drug release in hypoxic environment. Overall, the (PMPC)-P-H drug nanogels showed promising tumor inhibition effect in a glioblastoma model, with negligible side effects, offering a potential nanoplatform for treating hypoxic relevant diseases in the central nervous system.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Nanoscience & Nanotechnology

Zwitterionic Nanocapsules with Salt- and Thermo-Responsiveness for Controlled Encapsulation and Release

Zhijuan Sun et al.

Summary: Intelligent zwitterionic nanocapsules were synthesized using inverse reversible addition fragmentation transfer (RAFT) technique, allowing controlled release of encapsulated substances triggered by salt or temperature variations. The designed nanocapsules with defined core/shell structures and antifouling surfaces show promising applications in biomedical and saline related fields.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Pharmacology & Pharmacy

Hypoxia-degradable and long-circulating zwitterionic phosphorylcholine-based nanogel for enhanced tumor drug delivery

Shaojun Peng et al.

Summary: Hypoxia-responsive nanogels have been developed for tumor drug delivery, showing superior drug release and tumor inhibition effects compared to other degradable nanogels. The synthesized (PMPC)-P-H nanogel exhibits ultra-long blood circulation, desirable immune compatibility, and high and long-lasting accumulation in tumor tissue, making it a promising nanocarrier for advanced tumor drug delivery.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Chemistry, Multidisciplinary

Antifreezing Zwitterionic Hydrogel Electrolyte with High Conductivity of 12.6 mS cm-1 at-40 °C through Hydrated Lithium Ion Hopping Migration

Jianbo Yang et al.

Summary: The new zwitterionic polymer hydrogel electrolytes address the challenge of achieving high conductivity and flexibility at subzero temperatures, making them suitable for use in energy storage devices. The antifreezing electrolyte exhibits outstanding conductivity and mechanical properties, leading to high specific capacitance in supercapacitors.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Bio-Inspired Ionic Skin for Theranostics

Zhouyue Lei et al.

Summary: The research developed a biomimetic hydrogel to address the key challenges encountered by traditional synthetic hydrogel-based ionic skins, providing stability, adhesion, hydration, sensitive detection, and enhanced treatment efficacy in ambient conditions.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Engineering, Environmental

In situ generation of amphiphilic coatings based on a self-catalytic zwitterionic precursor and their antifouling performance

Donghui Wang et al.

Summary: The study developed a new zwitterionic precursor for easy fabrication of amphiphilic antifouling coatings, which effectively mitigated microfouling and demonstrated excellent resistance to mussel fouling. The precursor could hydrolyze in-situ into zwitterionic groups during the curing process, improving compatibility with PDMS and leading to a relatively homogeneous and smooth surface after prolonged submersion.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Environmental

A starch-based zwitterionic hydrogel coating for blood-contacting devices with durability and bio-functionality

Mengmeng Yao et al.

Summary: The study developed a novel hydrogel coating that effectively prevents thrombosis, exhibiting excellent biocompatibility and anti-adhesion properties. By introducing specific proteins on the coating surface, it promotes the adhesion and migration of specific cells while reducing the adhesion of others.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Physical

Zwitterion-functionalized mesoporous silica nanoparticles for enhancing oral delivery of protein drugs by overcoming multiple gastrointestinal barriers

Yikun Gao et al.

Summary: By modifying meso-porous silica nanoparticles with distinct coatings, the oral delivery of protein drugs was enhanced in terms of permeation and absorption in the gastrointestinal tract. Furthermore, the modified carrier showed reduced chances of entering lysosomes and displayed outstanding hypoglycemic effects in diabetic rats.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Zwitterionic self-assembled nanoparticles as carriers for Plasmodium targeting in malaria oral treatment

Arnau Biosca et al.

Summary: Novel nanoparticles were designed and synthesized to enhance the bioavailability of antimalarials, showing specific targeting to Plasmodium falciparum-infected red blood cells with maintained in vitro efficacy upon encapsulation of the lipophilic antimalarial drug curcumin. In vivo assays demonstrated increased curcumin concentration in mouse blood after oral administration of the nanoparticles, leading to similar antimalarial activities compared to free drug in Plasmodium yoelii yoelii-infected mice. Microscopic analysis revealed the presence of the polymer inside parasitized erythrocytes one hour after oral administration to infected animals.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Multidisciplinary Sciences

High-strength and fibrous capsule-resistant zwitterionic elastomers

Dianyu Dong et al.

Summary: This study presents a unique class of materials, called zwitterionic-elastomeric-networked (ZEN) hydrogels, which combine two weak zwitterionic hydrogels into a high-strength pure zwitterionic hydrogel to achieve both high mechanical properties and long-term resistance to fibrous capsule formation. This successful integration provides design principles for durable and fibrous capsule-resistant materials.

SCIENCE ADVANCES (2021)

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Article Nanoscience & Nanotechnology

Antifouling Antioxidant Zwitterionic Dextran Hydrogels as Wound Dressing Materials with Excellent Healing Activities

Xia Qiu et al.

Summary: Dextran-based hydrogels with zwitterionic structures showed faster wound healing rates compared to natural dextran hydrogel and commercial dressings, attributed to their protein resistance and ability to scavenge free radicals. These hydrogels also demonstrated excellent cytocompatibility and antibacterial properties, along with self-healing capabilities for irregular wounds, providing a new pathway for multifunctional polysaccharide hydrogels in wound treatment and pain relief during dressing changes.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Machine Learning-Enabled Design and Prediction of Protein Resistance on Self-Assembled Monolayers and Beyond

Yonglan Liu et al.

Summary: A data-driven machine learning model was developed to computationally design highly antifouling self-assembled monolayers (SAMs), demonstrating robustness and predictive ability. Experimental validation confirmed the accuracy of the model predictions, showcasing its potential for accelerating the discovery and understanding of functional materials for next-generation antifouling surfaces.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Kill-Resist-Renew Trinity: Hyperbranched Polymer with Self-Regenerating Attack and Defense for Antifouling Coatings

Guoxiong Dai et al.

Summary: This study presents a novel approach to combat marine biofouling by developing a polymeric coating with integrated fouling killing, resistance, and releasing functions. The coating degrades at the surface/seawater interface, generating antifouling and zwitterionic groups for effective protection. The controllable degradation rate and synergistic antibacterial effects make this coating a promising solution to the challenge of marine biofouling.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Strong Surface Hydration and Salt Resistant Mechanism of a New Nonfouling Zwitterionic Polymer Based on Protein Stabilizer TMAO

Hao Huang et al.

Summary: Research has shown that zwitterionic polymer brushes based on TMAO exhibit strong surface hydration, effectively resisting disruptions induced by salts and proteins, thus demonstrating excellent nonfouling performance.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Biophysics

Surface characterization of a silicone hydrogel contact lens having bioinspired 2-methacryloyloxyethyl phosphorylcholine polymer layer in hydrated state

Xinfeng Shi et al.

Summary: A silicone hydrogel contact lens material with unique chemical and physical structure was enhanced through surface modification using a bioinspired MPC polymer, resulting in improved surface characteristics such as hydrophilicity and lubricity. The hydrated MPC polymer layer on the surface led to softer surface properties and reduced friction, which are expected to contribute to excellent ocular performance.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Chemistry, Multidisciplinary

Nanoscaled Morphology and Mechanical Properties of a Biomimetic Polymer Surface on a Silicone Hydrogel Contact Lens

Xinfeng Shi et al.

Summary: The study modified the surface of a silicone hydrogel contact lens with a biomimetic phospholipid polymer to mimic the natural corneal tissue, resulting in nanoscaled concavities and convexities on the surface. The mechanical properties of the surface were found to be similar to natural tissues, and the material remained intact after 30 days of clinical use. These results demonstrate the validity of material preparation by biomimetic methods and suggest potential for development of human-friendly medical devices.

LANGMUIR (2021)

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Article Engineering, Biomedical

Inhibition of oral biofilm formation by zwitterionic nonfouling coating

Fang Sun et al.

Summary: The synthesized polymer coating is effective in inhibiting oral biofilm formation, reducing protein adsorption and bacterial adhesion significantly. It has great potential in future dental clinical applications for preventing dental caries and periodontal diseases.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2021)

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Article Engineering, Biomedical

Cartilage-like tribological performance of charged double network hydrogels

Shabnam Z. Bonyadi et al.

Summary: This study compared the tribological behavior of four double network hydrogels with fresh cartilage in water and FBS, finding that hydrogels with neutral or zwitterionic second networks exhibited the lowest friction and shear stresses, meeting or even surpassing the lubrication demands for cartilage replacement in load bearing joints. Differences in charge and structure were more pronounced in water than in FBS, with all hydrogels showing a wide range of lubrication responses. In FBS, most friction coefficient values were below 0.3, indicating a similar lubrication mechanism as that of cartilage in maintaining a stable solution layer at the interface during sliding.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface

Kazuhiko Ishihara et al.

Summary: A novel antifouling silicone hydrogel contact lens material with a cross-linked polymer layer of 2-methacryloyloxyethyl phosphorylcholine (MPC) was developed, showing significant resistance to lipid deposition and decreased fibroblast cell adhesion compared to conventional silicone hydrogel contact lenses. The MPC polymer layer improved surface properties and cell movement on the ocular tissue.

ACS OMEGA (2021)

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Article Engineering, Biomedical

Zwitterion-Driven Shape Program of Prodrug Nanoassemblies with High Stability, High Tumor Accumulation, and High Antitumor Activity

Guanting Li et al.

Summary: Zwitterionic surfactants have been shown to play a crucial role in the surface modification of prodrug nanoassemblies, impacting their in vivo fate and leading to the development of advanced nanomedicines with enhanced antitumor activity.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Reverse Actuation of Polyelectrolyte Effect for In Vivo Antifouling

Woojin Choi et al.

Summary: Zwitterionic polymers possess extraordinary properties such as significant hydration and the antipolyelectrolyte effect, making them suitable for biomedical applications. By studying the essential parameters, experimental verifications, and enhancing antifouling performance, it has been found that the antipolyelectrolyte effect can effectively reduce biofilm formation.

ACS NANO (2021)

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Article Biochemistry & Molecular Biology

Hypoxia-Sensitive Zwitterionic Vehicle for Tumor-Specific Drug Delivery through Antifouling-Based Stable Biotransport Alongside PDT-Sensitized Controlled Release

Tingjie Yin et al.

Summary: The hypoxia-sensitive zwitterionic vehicle D-High-PEI-(A+P) was developed for tumor-specific delivery of chemotherapeutics and biomacromolecules, with antifouling properties and photodynamic therapy-sensitized hypoxic response to enable controlled drug release. It demonstrated high drug loading, efficient tumor targeting, and responsive drug release, amplifying the therapeutic outcome with minimal collateral damage in orthotopic mouse models. D-High-PEI-(A+P) has the potential to serve as a universal vehicle for the tumor-specific delivery of drugs with diverse physicochemical properties.

BIOMACROMOLECULES (2021)

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Article Engineering, Biomedical

Combination of polycarboxybetaine coating and factor XII inhibitor reduces clot formation while preserving normal tissue coagulation during extracorporeal life support

Noritsugu Naito et al.

Summary: By comparing the effects of different anticoagulation methods on clot formation and bleeding times during ECLS, this study found that the combination of PCB coating and FXII900 inhibitor significantly reduced clotting and tissue bleeding times, making it a promising anticoagulation method for clinical ECLS.

BIOMATERIALS (2021)

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Article Engineering, Environmental

Zwitterionic hydrogel coated superhydrophilic hierarchical antifouling floater enables unimpeded interfacial steam generation and multi-contamination resistance in complex conditions

Chiyu Wen et al.

Summary: Developing antifouling coatings is crucial for ensuring the long-term and stable operation of solar desalination devices. The superhydrophilic hierarchical antifouling floater (SHAF) consists of zwitterionic hydrogel-coated materials, which can accelerate water evaporation and resist multiple contaminations.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Environmental

Polyzwitterion-crosslinked hybrid tissue with antithrombogenicity, endothelialization, anticalcification properties

Fan Yang et al.

Summary: This study developed a new method to copolymerize zwitterionic monomer and methacrylated porcine pericardium for the fabrication of TAV leaflets with robust antithrombotic and anticalcification properties. The experimental results showed that this new hybrid material has lower thrombogenicity and can effectively inhibit the calcification of valve leaflets, promising to extend the lifespan of TAV.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Polymer Science

Strong anti-polyelectrolyte zwitterionic hydrogels with superior self-recovery, tunable surface friction, conductivity, and antifreezing properties

Shengwei Xiao et al.

Summary: Salt-responsive hydrogels with zwitterionic monomer VBIPS were prepared, showing strong mechanical properties and recoverability. They exhibit different properties in water and salt solution, and after complexing with multivalent cations, a decreased freezing point was observed.

EUROPEAN POLYMER JOURNAL (2021)

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Article Chemistry, Physical

A Zwitterionic-Aromatic Motif-Based ionic skin for highly biocompatible and Glucose-Responsive sensor

Hongshuang Guo et al.

Summary: The novel zwitterionic-aromatic skin sensor exhibits high biocompatibility, anti-bacterial activity, glucose-responsive property, excellent mechanical properties, and sensitive pressure detection, making it a promising candidate for wearable e-skins and tissue-interfaced biosensors.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Engineering, Biomedical

An in situ-forming polyzwitterion hydrogel: Towards vitreous substitute application

Binbin He et al.

Summary: The study introduces a novel vitreous substitute based on zwitterionic polymer hydrogel, which exhibits excellent anti-fouling ability and biocompatibility, effectively reducing inflammatory responses and complications.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Biomedical

Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion-drug conjugates with cell-membrane affinity

Siqin Chen et al.

Summary: Conjugates of small-molecule anticancer drugs with a polyzwitterion that has negligible interaction with proteins and weak interaction with phospholipids can effectively eradicate large tumours and patient-derived tumour xenografts in mice by facilitating their transcytosis-mediated extravasation and infiltration into tumours, showcasing potential for translational anticancer nanomedicines.

NATURE BIOMEDICAL ENGINEERING (2021)

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Article Nanoscience & Nanotechnology

Lubricin-Inspired Loop Zwitterionic Peptide for Fabrication of Superior Antifouling Surfaces

Chuanxi Li et al.

Summary: Zwitterionic peptides with loop-like structures exhibit better antifouling properties by resisting protein and bacteria adsorption, being more rigid compared to linear-like peptides, reducing interaction with foulants, improving hydrophilicity, and avoiding chain aggregation. This study provides a comprehensive understanding of the conformation effect of zwitterionic peptides, which may contribute to the design of novel antifouling materials in various biomedical applications.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Pro-Healing Zwitterionic Skin Sensor Enables Multi-Indicator Distinction and Continuous Real-Time Monitoring

Hongshuang Guo et al.

Summary: A zwitterionic skin sensor system has been developed to continuously monitor and differentiate three-stimuli-responsive information in real-time, avoiding signal interference. This system utilizes a sandwich structure to monitor temperature, mechanical, and glucose information through variations in capacitance and resistance in different layers, which can be used for smart wound dressings to monitor chronic diabetic wounds.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

A General Crosslinker Strategy to Realize Intrinsic Frozen Resistance of Hydrogels

Dong Zhang et al.

Summary: The study introduces a novel crosslinking strategy to fabricate a series of antifreezing hydrogels with strong antifreezing and mechanical properties in various environments. The hydrogels are proposed to have a general antifreezing property regardless of their network compositions.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

High-Strength and Nonfouling Zwitterionic Triple-Network Hydrogel in Saline Environments

Xiaohui Li et al.

Summary: By constructing a pure zwitterionic triple-network (ZTN) hydrogel, both high mechanical strength and excellent nonfouling properties can be achieved; the strong electrostatic interaction and network entanglement within the structure effectively increase the toughness of the hydrogel, resulting in high strength, toughness, and stiffness in saline environments.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

A Zwitterionic Polyurethane Nanoporous Device with Low Foreign-Body Response for Islet Encapsulation

Qingsheng Liu et al.

Summary: The ZPU encapsulation device is developed with sulfobetaine groups in the polymer backbone, offering superior properties for cell encapsulation therapies with efficient mass transfer and prevention of cell escape. It has demonstrated therapeutic potential for islet encapsulation and treating diabetes, showing low foreign-body response and high biological compatibility.

ADVANCED MATERIALS (2021)

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Article Engineering, Biomedical

Mixed-charge pseudo-zwitterionic copolymer brush as broad spectrum antibiofilm coating

Yang Wu et al.

Summary: This study demonstrates the effectiveness of a novel mixed-charge copolymer brush coating in combating biofilm formation, outperforming traditional zwitterionic polymers. By utilizing oppositely charged monomers, a greater than 99% reduction in biofilm formation was achieved against various bacteria in vitro, with excellent long-term efficacy in murine infection models. These findings suggest the potential of combining readily available singly charged monomers for potent antibiofilm applications.

BIOMATERIALS (2021)

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Article Engineering, Environmental

Ionic conductive hydrogels with long-lasting antifreezing, water retention and self-regeneration abilities

Xiaojie Sui et al.

Summary: Conductive hydrogels face issues of water freezing, water loss, and inability to self-regenerate, but the introduction of highly hydratable lithium chloride has led to the development of a novel ionic conductive hydrogel with antifreezing, water retention, and self-regeneration abilities. This hydrogel can withstand ultralow temperatures for extended periods and rapidly self-regenerate even in dehydrated states.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Environmental

Machine Learning-Enabled Repurposing and Design of Antifouling Polymer Brushes

Yonglan Liu et al.

Summary: This study developed a data-driven, machine learning workflow combined with a benchmark dataset to discover the antifouling property of existing polymer brushes and design new ones. The resulting machine learning models showed reliability, predictivity, and established composition-structure-property relationships.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Environmental

A water-triggered highly self-healable elastomer with enhanced mechanical properties achieved using localized zwitterionic assemblies

Jungsoon Kang et al.

Summary: This study demonstrates the synthesis of a water-triggered highly self-healable elastomer with excellent optical and mechanical properties through localized zwitterionic assemblies using a newly proposed blending method. The elastomer with localized zwitterionic clusters shows superior self-healing efficiency under both dry and wet conditions compared with conventional nonionic elastomers and ionic elastomers with randomly distributed ions. These properties are attributed to the unique intermolecular network resulting from strong interactions between localized zwitterionic clusters.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Chemistry, Multidisciplinary

Nonspecific Binding-Fundamental Concepts and Consequences for Biosensing Applications

Andreas Frutiger et al.

Summary: The differentiation between specific and nonspecific binding in molecular interactions has been achieved in nature through precise control of biomolecules. However, artificial biosensors have struggled to overcome this issue. Through theoretical models and classification frameworks, it is possible to gain a better understanding and optimize the performance of biosensors, while exploring ways to address the challenge of nonspecific binding.

CHEMICAL REVIEWS (2021)

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Article Chemistry, Physical

Cartilage lamina splendens inspired nanostructured coating for biomaterial lubrication

Hongping Wan et al.

Summary: A nanostructured film based on hyaluronic acid and glutathione was proposed to enhance lubrication between cartilage and PCU. The coating of HADN-Glu effectively protected cartilage and exhibited successful grafting onto the PCU surface, enabling enhanced lubrication for potential implant design.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Chemistry, Physical

Marine antifouling coatings with surface topographies triggered by phase segregation

Xin Su et al.

Summary: Marine biofouling is a widespread and longstanding challenge, and new coating technologies can effectively address this issue. Surface structure designs triggered by phase segregation can endow coatings with antifouling properties and reduce the driving forces for marine organism adsorption.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Engineering, Environmental

Multifunctional filtration membrane with anti-viscous-oils-fouling capacity and selective dyes adsorption ability for complex wastewater remediation

Liang Zhou et al.

Summary: This study presents a simple method to fabricate multifunctional filtration membranes (MFMs) with super-hydrophilic/underwater super-oleophobic performance for purifying oil-in-water emulsions. The MFM shows strong chemical and physical resistance, as well as the ability to adsorb soluble dyes and metallic ions, making it ideal for treating complex wastewater.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Materials Science, Biomaterials

Zwitterionic hydrogel-coated heart valves with improved endothelialization and anti-calcification properties

Yu Luo et al.

Summary: In this study, modified bioprosthetic heart valves with enhanced endothelial cell affinity were developed to improve biocompatibility and anti-calcification properties. After 30 days of subcutaneous implantation, the improved valves showed reduced immune response and calcification compared to traditional BHVs.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Multidisciplinary Sciences

Skin-like mechanoresponsive self-healing ionic elastomer from supramolecular zwitterionic network

Wei Zhang et al.

Summary: The stretchable ionic elastomer demonstrated in the study exhibits high stretchability, immense strain-stiffening, good self-healing ability, excellent elasticity, high transparency, anti-freezing properties, water reprocessibility, and easy-to-peel adhesion, making it very promising for use in wearable electronic sensors for human-machine interfacing.

NATURE COMMUNICATIONS (2021)

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Article Polymer Science

Anticancer Activity of Cell -Penetrating Redox Phospholipd Polymers

Masahiro Kaneko et al.

Summary: Redox phospholipid polymers composed of ferrocene or quinone units were prepared as anticancer redox polymers, which can disrupt intracellular redox state and selectively suppress the viability of cancer cells based on their reactivity with intracellular redox species and O-2. The redox potential of the polymers plays a critical role in determining the impact on the viability of human cancer and normal cells.

ACS MACRO LETTERS (2021)

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Article Materials Science, Multidisciplinary

Emulsion-Based Organohydrogels with Switchable Wettability and Underwater Adhesion toward Durable and Ecofriendly Marine Antifouling Coatings

Zhuo Zhang et al.

Summary: The COHGs fabricated in this study exhibit excellent mechanical properties and low-swellable behavior in water or oil, thanks to the synergistic collaboration of covalent linkages, electrostatic interaction, and hydrogen bonding. The amphiphilic heteronetworks possess switchable surface wettability in response to different solvents, and strong wet adhesion to various surfaces, making them ideal for practical applications. The elastic surfaces combined with amphiphilic and zwitterionic features show remarkable fouling resistance and recyclable utilization, presenting a promising approach for the development of high-performance and ecofriendly antifouling materials.

ACS APPLIED POLYMER MATERIALS (2021)

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Article Medicine, Research & Experimental

Charge-switchable zwitterionic polycarboxybetaine particle as an intestinal permeation enhancer for efficient oral insulin delivery

Yan Li et al.

Summary: The study utilized charge-switchable zwitterionic polycarboxybetaine (PCB) to load insulin and form PCB/insulin (PCB/INS) particles, which showed an opening effect on intestinal epithelium, increasing the intestinal permeability of insulin and enhancing the antidiabetic efficacy after oral administration.

THERANOSTICS (2021)

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Review Chemistry, Multidisciplinary

Power generation for wearable systems†

Mingyuan Gao et al.

Summary: Wearable devices are gaining increasing attention for their potential to transform the digital world. This paper reviews cutting-edge power generation methodologies for wearables, discusses key factors such as sensor types and materials, and outlines future directions in wearable technology development.

ENERGY & ENVIRONMENTAL SCIENCE (2021)

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Article Materials Science, Biomaterials

Bioinspired zwitterionic polyphosphoester modified porous silicon nanoparticles for efficient oral insulin delivery

Rong Rao et al.

Summary: The study showed that zwitterionic polyphosphoester modified porous silicon nanoparticles play an important role in oral delivery of protein or peptide drugs, enhancing mucus permeability and cellular internalization.

BIOMATERIALS SCIENCE (2021)

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Article Materials Science, Biomaterials

Bifunctional polymer brush-grafted coronary stent for anticoagulation and endothelialization

Tianyu Zhu et al.

Summary: A bifunctional polymer brush-grafted coronary stent was developed to address clinical complications such as delayed endothelialization, late thrombosis and restenosis. The coating demonstrated good anticoagulant property and significant endothelialization effect, potentially offering a solution to post-operative side effects associated with restenosis and late stent thrombosis.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Chemistry, Multidisciplinary

A Multifunctional Pro-Healing Zwitterionic Hydrogel for Simultaneous Optical Monitoring of pH and Glucose in Diabetic Wound Treatment

Yingnan Zhu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Engineering, Chemical

Zwitterionic electrospun PVDF fibrous membranes with a well-controlled hydration for diabetic wound recovery

Antoine Venault et al.

JOURNAL OF MEMBRANE SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Zwitterionic Nanohydrogels-Decorated Microporous Membrane with Ultrasensitive Salt Responsiveness for Controlled Water Transport

Aqiang Wang et al.

SMALL (2020)

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Article Chemistry, Multidisciplinary

Zwitterionic Osmolyte-Based Hydrogels with Antifreezing Property, High Conductivity, and Stable Flexibility at Subzero Temperature

Xiaojie Sui et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Engineering, Biomedical

Developing mechanically robust, triazole-zwitterionic hydrogels to mitigate foreign body response (FBR) for islet encapsulation

Qingsheng Liu et al.

BIOMATERIALS (2020)

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Article Engineering, Biomedical

Cartilage matrix-inspired biomimetic superlubricated nanospheres for treatment of osteoarthritis

Hao Chen et al.

BIOMATERIALS (2020)

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Article Engineering, Environmental

Three-dimensional flower-like shaped Bi5O7I particles incorporation zwitterionic fluorinated polymers with synergistic hydration-photocatalytic for enhanced marine antifouling performance

Linlin Zhang et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Article Engineering, Chemical

Improved anti-biofouling performance of polyamide reverse osmosis membranes modified with a polyampholyte with effective carboxyl anion and quaternary ammonium cation ratio

Zhe Yang et al.

JOURNAL OF MEMBRANE SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Zwitterionic Polymer Micelles with Dual Conjugation of Doxorubicin and Curcumin: Synergistically Enhanced Efficacy against Multidrug-Resistant Tumor Cells

Guangfu Zhao et al.

LANGMUIR (2020)

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Article Engineering, Mechanical

Synthesis and characterizations of zwitterionic copolymer hydrogels with excellent lubrication behavior

Zhongnan Wang et al.

TRIBOLOGY INTERNATIONAL (2020)

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Review Nanoscience & Nanotechnology

Design of biodegradable, implantable devices towards clinical translation

Chunmei Li et al.

NATURE REVIEWS MATERIALS (2020)

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Article Materials Science, Multidisciplinary

Quantification of the scratch-healing efficiency for novel zwitterionic polymers

Jan Dahlke et al.

NPG ASIA MATERIALS (2020)

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Article Nanoscience & Nanotechnology

Stable Fabrication of Zwitterionic Coating Based on Copper-Phenolic Networks on Contact Lens with Improved Surface Wettability and Broad-Spectrum Antimicrobial Activity

Gongyan Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

An On-Skin Electrode with Anti-Epidermal-Surface-Lipid Function Based on a Zwitterionic Polymer Brush

Ke He et al.

ADVANCED MATERIALS (2020)

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Article Biochemistry & Molecular Biology

Synthesis and Hydration Behavior of a Hydrolysis-Resistant Quasi-Choline Phosphate Zwitterionic Polymer

Masaru Mukai et al.

BIOMACROMOLECULES (2020)

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Review Biochemistry & Molecular Biology

Interactions between Biomolecules and Zwitterionic Moieties: A Review

Amir Erfani et al.

BIOMACROMOLECULES (2020)

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Article Chemistry, Applied

Cytocompatible and non-fouling zwitterionic hyaluronic acid-based hydrogels using thiol-ene click chemistry for cell encapsulation

Yabin Zhang et al.

CARBOHYDRATE POLYMERS (2020)

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Article Engineering, Environmental

Multi-functional zwitterionic coating for silicone-based biomedical devices

Wan Peng et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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MPC-grafted highly cross-linked polyethylene liners retrieved from short-term total hip arthroplasty: Further evidences for the unsuitability of the MPC method

Takashi Hosoi et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2020)

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Review Biochemistry & Molecular Biology

Biofilm Matrixome: Extracellular Components in Structured Microbial Communities

L. Karygianni et al.

TRENDS IN MICROBIOLOGY (2020)

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Quantifying the Search for Solid Li-Ion Electrolyte Materials by Anion: A Data-Driven Perspective

Austin D. Sendek et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2020)

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Synthesis and Characterization of Zwitterionic Polymer Brush Functionalized Hydrogels with Ionic Responsive Coefficient of Friction

Allen O. Osaheni et al.

LANGMUIR (2020)

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Article Materials Science, Multidisciplinary

Zwitterionic polymers and hydrogels for antibiofouling applications in implantable devices

Nandanan Erathodiyil et al.

MATERIALS TODAY (2020)

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Mucopenetrating Zwitterionic Micelles

Essi Taipaleenmaki et al.

CHEMNANOMAT (2020)

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Zwitterionic Nanoconjugate Enables Safe and Efficient Lymphatic Drug Delivery

Bowen Li et al.

NANO LETTERS (2020)

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De novo design of functional zwitterionic biomimetic material for immunomodulation

Bowen Li et al.

SCIENCE ADVANCES (2020)

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Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions

Xiangfei Han et al.

NATURE NANOTECHNOLOGY (2020)

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Amphiphilic Dicyclopentenyl/Carboxybetaine-Containing Copolymers for Marine Fouling-Release Applications

Florian Koschitzki et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Zwitterionic carboxybetaine polymers extend the shelf-life of human platelets

Xiaojie Lin et al.

ACTA BIOMATERIALIA (2020)

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Article Chemistry, Physical

Surface plasma Ag-decorated Bi5O7I microspheres uniformly distributed on a zwitterionic fluorinated polymer with superfunctional antifouling property

Linlin Zhang et al.

APPLIED CATALYSIS B-ENVIRONMENTAL (2020)

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Article Biochemical Research Methods

Zwitterionic Polymer Conjugated Glucagon-like Peptide-1 for Prolonged Glycemic Control

Caroline Tsao et al.

BIOCONJUGATE CHEMISTRY (2020)

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Article Polymer Science

High strength zwitterionic nano-micelle hydrogels with superior self-healing, adhesive and ion conductive properties

Yuanna Sun et al.

EUROPEAN POLYMER JOURNAL (2020)

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Encapsulation and delivery of protein from within poly(sulfobetaine) hydrogel beads

Amir Erfani et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2020)

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Enhanced pulmonary systemic delivery of protein drugs via zwitterionic polymer conjugation

Caroline Tsao et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Engineering, Marine

Marine Biofouling: A European Database for the Marine Renewable Energy Sector

Pedro Almeida Vinagre et al.

JOURNAL OF MARINE SCIENCE AND ENGINEERING (2020)

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Anti-Biofouling Strategies for Long-Term Continuous Use of Implantable Biosensors

Jian Xu et al.

CHEMOSENSORS (2020)

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Photoreactive Carboxybetaine Copolymers Impart Biocompatibility and Inhibit Plasticizer Leaching on Polyvinyl Chloride

Xiaojie Lin et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Surface Zwitterionization of Expanded Poly(tetrafluoroethylene) via Dopamine-Assisted Consecutive Immersion Coating

Peter Matthew Paul T. Fowler et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Zwitterionic Hydrogel-Impregnated Membranes with Polyamide Skin Achieving Superior Water/Salt Separation Properties

Thien Tran et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Simultaneous amphiphilic polymer synthesis and membrane functionalization for oil/water separation

Antoine Venault et al.

JOURNAL OF MEMBRANE SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Zwitterionic 3D-Printed Non-Immunogenic Stealth Microrobots

Poi Cabanach et al.

ADVANCED MATERIALS (2020)

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Zwitterionic Polydopamine Engineered Interface for In Vivo Sensing with High Biocompatibility

Taotao Feng et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Zwitterionic Peptide Cloak Mimics Protein Surfaces for Protein Protection

Zhefan Yuan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Superlubricity of Zwitterionic Bottlebrush Polymers in the Presence of Multivalent Ions

Vahid Adibnia et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Chemistry, Multidisciplinary

MOF-Based Antibiofouling Hemoadsorbent for Highly Efficient Removal of Protein-Bound Bilirubin

Qingsi Li et al.

LANGMUIR (2020)

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Article Biophysics

Antifouling silicone hydrogel contact lenses via densely grafted phosphorylcholine polymers

Alysha Spadafora et al.

BIOINTERPHASES (2020)

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Zwitterionic hydrogels formed via quadruple hydrogen-bonds with ultra-fast room-temperature self-healing ability

Yinlei Lin et al.

MATERIALS LETTERS (2020)

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Article Engineering, Biomedical

Superhydrophilic fluorinated polymer and nanogel for high-performance 19F magnetic resonance imaging

Zujian Feng et al.

BIOMATERIALS (2020)

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Article Multidisciplinary Sciences

Rational flux-tuning of Halomonas bluephagenesis for co-production of bioplastic PHB and ectoine

Hong Ma et al.

NATURE COMMUNICATIONS (2020)

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Integration of photo-induced biocidal and hydrophilic antifouling functions on nanofibrous membranes with demonstrated reduction of biofilm formation

Yue Ma et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2020)

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Article Chemistry, Physical

Mussel-inspired triblock functional protein coating with endothelial cell selectivity for endothelialization

Weiwei Zheng et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2020)

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Zwitterionic nanogels modified nanofibrous membrane for efficient oil/water separation

Linlin Zang et al.

JOURNAL OF MEMBRANE SCIENCE (2020)

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Dual Action Antimicrobial Surfaces: Alternating Photopatterns Maintain Contact-Killing Properties with Reduced Biofilm Formation

Lewis D. Blackman et al.

MACROMOLECULAR MATERIALS AND ENGINEERING (2020)

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Ball-Bearing-Inspired Polyampholyte-Modified Microspheres as Bio-Lubricants Attenuate Osteoarthritis

Jielai Yang et al.

SMALL (2020)

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Active Transportation of Liposome Enhances Tumor Accumulation, Penetration, and Therapeutic Efficacy

Guowei Wang et al.

SMALL (2020)

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Data-Driven Prediction of Protein Adsorption on Self-Assembled Monolayers toward Material Screening and Design

Rudolf Jason Kwaria et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Chemistry, Applied

Self-polishing emulsion platforms: Eco-friendly surface engineering of coatings toward water borne marine antifouling

Jianbin Zhang et al.

PROGRESS IN ORGANIC COATINGS (2020)

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Seawater-responsive SiO2 nanoparticles for in situ generation of zwitterionic polydimethylsiloxane antifouling coatings with underwater superoleophobicity

Jinyan Tan et al.

JOURNAL OF MATERIALS CHEMISTRY A (2020)

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Cartilage-inspired, lipid-based boundary-lubricated hydrogels

Weifeng Lin et al.

SCIENCE (2020)

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Surface hydration for antifouling and bio-adhesion

Chelsey A. Del Grosso et al.

CHEMICAL SCIENCE (2020)

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A zwitterionic hydrogel coated titanium surface with high-efficiency endothelial cell selectivity for rapid re-endothelialization

Chiyu Wen et al.

BIOMATERIALS SCIENCE (2020)

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Single and multi-functional coating strategies for enhancing the biocompatibility and tissue integration of blood-contacting medical implants

Maryam Badv et al.

BIOMATERIALS (2020)

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Phospholipid-mimicking cell-penetrating polymers: principles and applications

Tatsuro Goda et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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A self-healable and antifouling hydrogel based on PDMS centered ABA tri-block copolymer polymersomes: a potential material for therapeutic contact lenses

Sovan Lal Banerjee et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Chemistry, Multidisciplinary

Latest advances in zwitterionic structures modified dialysis membranes

A. Mollahosseini et al.

MATERIALS TODAY CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Winning the fight against biofilms: the first six-month study showing no biofilm formation on zwitterionic polyurethanes

Huifeng Wang et al.

CHEMICAL SCIENCE (2020)

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QSAR without borders

Eugene N. Muratov et al.

CHEMICAL SOCIETY REVIEWS (2020)

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Article Medicine, Research & Experimental

Zwitterionic-to-cationic charge conversion polyprodrug nanomedicine for enhanced drug delivery

Sheng Wang et al.

THERANOSTICS (2020)

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Article Materials Science, Biomaterials

Molecular simulations and understanding of antifouling zwitterionic polymer brushes

Yonglan Liu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Stretchable, self-healing and tissue-adhesive zwitterionic hydrogels as strain sensors for wireless monitoring of organ motions

Xinjie Pei et al.

MATERIALS HORIZONS (2020)

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Article Nanoscience & Nanotechnology

Artificial Heart Valves with Balanced Charged Networks Exhibiting Anti-Calcification Properties

Feng Guo et al.

ACS APPLIED BIO MATERIALS (2020)

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Superhydrophilic Anti-Icing Coatings Based on Polyzwitterion Brushes

Bang Liang et al.

LANGMUIR (2019)

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Development of Zwitterionic Polypeptide Nanoformulation with High Doxorubicin Loading Content for Targeted Drug Delivery

Weifeng Lin et al.

LANGMUIR (2019)

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Mixed-Charged Zwitterionic Polymeric Micelles for Tumor Acidic Environment Responsive Intracellular Drug Delivery

Zhihui Qin et al.

LANGMUIR (2019)

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Blood-Compatible Surfaces with Phosphorylcholine-Based Polymers for Cardiovascular Medical Devices

Kazuhiko Ishihara

LANGMUIR (2019)

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Article Chemistry, Multidisciplinary

Bioinspired Polydopamine/Polyzwitterion Coatings for Underwater Anti-Oil and -Freezing Surfaces

Meng-Qi Ma et al.

LANGMUIR (2019)

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Article Chemistry, Multidisciplinary

Atomistic Study of Zwitterionic Peptoid Antifouling Brushes

David L. Cheung et al.

LANGMUIR (2019)

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Biodegradable Zwitterionic Polymer Coatings for Magnesium Alloy Stents

Sang-Ho Ye et al.

LANGMUIR (2019)

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Article Engineering, Biomedical

Long circulating genetically encoded intrinsically disordered zwitterionic polypeptides for drug delivery

Samagya Banskota et al.

BIOMATERIALS (2019)

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Review Biochemistry & Molecular Biology

Biomaterials: Foreign Bodies or Tuners for the Immune Response?

Erminia Mariani et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Polymer Science

Highly stretchable, ionic conductive and self-recoverable zwitterionic polyelectrolyte-based hydrogels by introducing multiple supramolecular sacrificial bonds in double network

Wenjing Diao et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2019)

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Review Engineering, Biomedical

Revolutionary advances in 2-methacryloyloxyethyl phosphorylcholine polymers as biomaterials

Kazuhiko Ishihara

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2019)

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Article Cardiac & Cardiovascular Systems

A comparison of low and standard anti-coagulation regimens in extracorporeal membrane oxygenation

Jaishankar Raman et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2019)

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Biofouling Control Using Nano Silicon Dioxide Reinforced Mixed-Charged Zwitterionic Hydrogel in Aquaculture Cage Nets

Ahana Mohan et al.

LANGMUIR (2019)

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Review Pharmacology & Pharmacy

Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

Bahman Homayun et al.

PHARMACEUTICS (2019)

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Rechargeable Antibacterial N-Halamine Films with Antifouling Function for Food Packaging Applications

Yue Ma et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Zwitterionic poly-carboxybetaine coating reduces artificial lung thrombosis in sheep and rabbits

Rei Ukita et al.

ACTA BIOMATERIALIA (2019)

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Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration

Duo Xu et al.

ADVANCED MATERIALS (2019)

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Review Biochemical Research Methods

Protein PEPylation: A New Paradigm of Protein-Polymer Conjugation

Yingqin Hou et al.

BIOCONJUGATE CHEMISTRY (2019)

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Substrate-independent polyzwitterionic coating for oil/water separation membranes

Bang Liang et al.

CHEMICAL ENGINEERING JOURNAL (2019)

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Design of Stretchable and Self-Healing Gel Electrolytes via Fully Zwitterionic Polymer Networks in Solvate Ionic Liquids for Li-Based Batteries

Anthony J. D'Angelo et al.

CHEMISTRY OF MATERIALS (2019)

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Article Biophysics

A hemocompatible cryoprotectant inspired by freezing-tolerant plants

Jing Yang et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Translocation Mechanisms of Cell-Penetrating Polymers Identified by Induced Proton Dynamics

Tatsuro Goda et al.

LANGMUIR (2019)

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Nanovoid Membranes Embedded with Hollow Zwitterionic Nanocapsules for a Superior Desalination Performance

Zhijuan Sung et al.

NANO LETTERS (2019)

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Exploiting machine learning for end-to-end drug discovery and development

Sean Ekins et al.

NATURE MATERIALS (2019)

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Applications of machine learning in drug discovery and development

Jessica Vamathevan et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Articular Cartilage-Inspired Surface Functionalization for Enhanced Lubrication

Yixin Wang et al.

ADVANCED MATERIALS INTERFACES (2019)

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In Situ Encapsulation of Postcryopreserved Cells Using Alginate Polymer and Zwitterionic Betaine

Jing Yang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

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Bioinspired Multifunctional Protein Coating for Antifogging, Self-Cleaning, and Antimicrobial Properties

Haishan Qi et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Multiscale modeling and simulations of protein adsorption: progresses and perspectives

Xuebo Quan et al.

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE (2019)

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Novel mussel-inspired zwitterionic hydrophilic polymer to boost membrane water-treatment performance

Hongguang Sun et al.

JOURNAL OF MEMBRANE SCIENCE (2019)

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Fundamentals and applications of zwitterionic antifouling polymers

Yanxian Zhang et al.

JOURNAL OF PHYSICS D-APPLIED PHYSICS (2019)

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Enzyme-activatable polymer-drug conjugate augments tumour penetration and treatment efficacy

Quan Zhou et al.

NATURE NANOTECHNOLOGY (2019)

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A highly transparent and ultra-stretchable conductor with stable conductivity during large deformation

Zhouyue Lei et al.

NATURE COMMUNICATIONS (2019)

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Trimethylamine N-oxide-derived zwitterionic polymers: A new class of ultralow fouling bioinspired materials

Bowen Li et al.

SCIENCE ADVANCES (2019)

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Nonfreezable Water and Polymer Swelling Control the Marine Antifouling Performance of Polymers with Limited Hydrophilic Content

Jan H. Kardela et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Beetle-Inspired Hierarchical Antibacterial Interface for Reliable Fog Harvesting

Chiyu Wen et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Transparent and Scratch-Resistant Antifogging Coatings with Rapid Self-Healing Capability

Bang Liang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Biochemistry & Molecular Biology

Dimethyl Sulfoxide-Free Cryopreservation of Chondrocytes Based on Zwitterionic Molecule and Polymers

Min Liu et al.

BIOMACROMOLECULES (2019)

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Zwitterionic Janus Dendrimer with distinct functional disparity for enhanced protein delivery

Lili Wang et al.

BIOMATERIALS (2019)

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Hypoxia-targeting dendritic MRI contrast agent based on internally hydroxy dendrimer for tumor imaging

Yuxin Han et al.

BIOMATERIALS (2019)

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Molecular Scale Solvation in Complex Solutions

Ellen E. Bruce et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Zwitterionic PMCP-Modified Polycaprolactone Surface for Tissue Engineering: Antifouling, Cell Adhesion Promotion, and Osteogenic Differentiation Properties

Xingyu Chen et al.

SMALL (2019)

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Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice

Jing Wen et al.

NATURE BIOMEDICAL ENGINEERING (2019)

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Self-Generating and Self-Renewing Zwitterionic Polymer Surfaces for Marine Anti-Biofouling

Guoxiong Dai et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Zwitterionic polymer ligands: an ideal surface coating to totally suppress protein-nanoparticle corona formation?

Manon Debayle et al.

BIOMATERIALS (2019)

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Hemocompatible hemoadsorbent for effective removal of protein-bound toxin in serum

Qings Li et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Hydration and Dynamics of Ligands Determine the Antifouling Capacity of Functionalized Surfaces

Matthew Penna et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2019)

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Expansion of primitive human hematopoietic stem cells by culture in a zwitterionic hydrogel

Tao Bai et al.

NATURE MEDICINE (2019)

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Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation

Qingsheng Liu et al.

NATURE COMMUNICATIONS (2019)

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Tough, Adhesive, Self-Healable, and Transparent Ionically Conductive Zwitterionic Nanocomposite Hydrogels as Skin Strain Sensors

Liufang Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Mixed-charge pseudo-zwitterionic mesoporous silica nanoparticles with low-fouling and reduced cell uptake properties

Noemi Encinas et al.

ACTA BIOMATERIALIA (2019)

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The Crown and the Scepter: Roles of the Protein Corona in Nanomedicine

Rong Cai et al.

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Finding the Right Bricks for Molecular Legos: A Data Mining Approach to Organic Semiconductor Design

Christian Kunkel et al.

CHEMISTRY OF MATERIALS (2019)

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Zwitterionic polymer/polydopamine coating reduce acute inflammatory tissue responses to neural implants

Asiyeh Golabchi et al.

BIOMATERIALS (2019)

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Specific Ion Effects in Polyampholyte Hydrogels Dialyzed in Aqueous Electrolytic Solutions

Hemant Charaya et al.

LANGMUIR (2019)

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Nanoscavenger provides long-term prophylactic protection against nerve agents in rodents

Peng Zhang et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Quantitative design rules for protein-resistant surface coatings using machine learning

Tu C. Le et al.

SCIENTIFIC REPORTS (2019)

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Understanding the Antifouling Mechanism of Zwitterionic Monomer-Grafted Polyvinylidene Difluoride Membranes: A Comparative Experimental and Molecular Dynamics Simulation Study

Zi-Yu Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Rational Design of Cancer Nanomedicine for Simultaneous Stealth Surface and Enhanced Cellular Uptake

Qiao Jin et al.

ACS NANO (2019)

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In Vivo Imaging of Single Tumor Cells in Fast-Flowing Bloodstream Using Near-Infrared Quantum Dots and Time-Gated Imaging

Thomas Pons et al.

ACS NANO (2019)

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Rapid and Long-Term Glycemic Regulation with a Balanced Charged Immune-Evasive Hydrogel in T1DM Mice

Jiamin Zhang et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System

Di Wu et al.

ADVANCED MATERIALS (2019)

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Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy

Lei Han et al.

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An introduction to zwitterionic polymer behavior and applications in solution and at surfaces

Lewis D. Blackman et al.

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Domesticating the foreign body response: Recent advances and applications

Omid Veiseh et al.

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Anti-biofilm surfaces from mixed dopamine-modified polymer brushes: synergistic role of cationic and zwitterionic chains to resist staphyloccocus aureus

Yuanyuan He et al.

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Zwitterionic copolymer additive architecture affects membrane performance: fouling resistance and surface rearrangement in saline solutions

Papatya Kaner et al.

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Human Biomolecular Corona of Liposomal Doxorubicin: The Overlooked Factor in Anticancer Drug Delivery

Giulio Caracciolo et al.

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Novel Balanced Charged Alginate/PEI Polyelectrolyte Hydrogel that Resists Foreign-Body Reaction

Jiamin Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Biodegradable Zwitterionic Nanogels with Long Circulation for Antitumor Drug Delivery

Yongzhi Men et al.

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Sulfated zwitterionic poly(sulfobetaine methacrylate) hydrogels promote complete skin regeneration

Jiang Wu et al.

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Zwitterionic Nanocages Overcome the Efficacy Loss of Biologic Drugs

Bowen Li et al.

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An Ethylenediamine-based Switch to Render the Polyzwitterion Cationic at Tumorous pH for Effective Tumor Accumulation of Coated Nanomaterials

Abdul-Hackam Ranneh et al.

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Polypeptides with High Zwitterion Density for Safe and Effective Therapeutics

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Mitigation of Inflammatory Immune Responses with Hydrophilic Nanoparticles

Bowen Li et al.

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Bayesian inference for mining semiconductor manufacturing big data for yield enhancement and smart production to empower industry 4.0

Marzieh Khakifirooz et al.

APPLIED SOFT COMPUTING (2018)

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Zwitterionic starch-based hydrogel for the expansion and sternness maintenance of brown adipose derived stem cells

Dianyu Dong et al.

BIOMATERIALS (2018)

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Polydopamine/cysteine surface modified hemocompatible poly(vinylidene fluoride) hollow fiber membranes for hemodialysis

Zihan An et al.

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Surface zwitterionization of PVDF VIPS membranes for oil and water separation

Antoine Venault et al.

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Bacterial biofilm and associated infections

Muhsin Jamal et al.

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Molecular Simulations of the Hydration Behavior of a Zwitterion Brush Array and Its Antifouling Property in an Aqueous Environment

Yuan Xiang et al.

LANGMUIR (2018)

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Nanocapsules of oxalate oxidase for hyperoxaluria treatment

Ming Zhao et al.

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Implant infections: adhesion, biofilm formation and immune evasion

Carla Renata Arciola et al.

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Ionic liquids for oral insulin delivery

Amrita Banerjee et al.

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Synthesis, antibacterial activity, and application in the antifouling marine coatings of novel acylamino compounds containing gramine groups

Kang Feng et al.

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Formation of zwitterionic coatings with an aqueous lubricating layer for antifogging/anti-icing applications

Chao Tao et al.

PROGRESS IN ORGANIC COATINGS (2018)

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Potential of synthetic chalcone derivatives to prevent marine biofouling

J. R. Almeida et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2018)

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Highly sensitive and stable zwitterionic poly(sulfobetaine-3,4-ethylenedioxythiophene) (PSBEDOT) glucose biosensor

Haiyan Wu et al.

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Synthesis of Phosphatidylserine and Its Stereoisomers: Their Role in Activation of Blood Coagulation

Suman Mallik et al.

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Single quantum dot tracking reveals the impact of nanoparticle surface on intracellular state

Mohammad U. Zahid et al.

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A supramolecular biomimetic skin combining a wide spectrum of mechanical properties and multiple sensory capabilities

Zhouyue Lei et al.

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Progress and challenges towards targeted delivery of cancer therapeutics

Daniel Rosenblum et al.

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Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis

Eleni Bekiari et al.

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Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis

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Salt-responsive zwitterionic polymer brushes with anti-polyelectrolyte property

Shengwei Xiao et al.

CURRENT OPINION IN CHEMICAL ENGINEERING (2018)

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Micelles with ultralow critical micelle concentration as carriers for drug delivery

Yang Lu et al.

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Stretchable and Self-Healing Integrated All-Gel-State Supercapacitors Enabled by a Notch-Insensitive Supramolecular Hydrogel Electrolyte

Yunhui Shi et al.

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Zwitterionic Nanohydrogel Grafted PVDF Membranes with Comprehensive Antifouling Property and Superior Cycle Stability for Oil-in-Water Emulsion Separation

Yuzhang Zhu et al.

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Self-Healing Zwitterionic Microgels as a Versatile Platform for Malleable Cell Constructs and Injectable Therapies

Andrew Sinclair et al.

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Revealing the Immunogenic Risk of Polymers

Bowen Li et al.

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A mussel-inspired chimeric protein as a novel facile antifouling coating

Haishan Qi et al.

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Fabrication of Nafion/zwitterion-functionalized covalent organic framework composite membranes with improved proton conductivity

Yan Li et al.

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Zwitterlation mitigates protein bioactivity loss in vitro over PEGylation

Yanjiao Han et al.

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Antifouling Super Water Absorbent Supramolecular Polymer Hydrogel as an Artificial Vitreous Body

Hongbo Wang et al.

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Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer

Xi Xie et al.

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Zwitterionic Polyurethanes with Tunable Surface and Bulk Properties

Huifeng Wang et al.

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Zwitterionic Skins with a Wide Scope of Customizable Functionalities

Zhouyue Lei et al.

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Multiple-Responsive Mesoporous Silica Nanoparticles for Highly Accurate Drugs Delivery to Tumor Cells

Ronghua Jin et al.

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Zwitterionic poly(sulfobetaine methacrylate)s in water: from upper critical solution temperature (UCST) to lower critical solution temperature (LCST) with increasing length of one alkyl substituent on the nitrogen atom

Ning Wang et al.

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Gram-Scale Preparation of Iron Oxide Nanoparticles with Renal Clearance Properties for Enhanced T1-Weighted Magnetic Resonance Imaging

Guohai Liang et al.

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Emergent heterogeneous microenvironments in biofilms: substratum surface heterogeneity and bacterial adhesion force-sensing

Yijin Ren et al.

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Dual water-healable zwitterionic polymer coatings for anti-biofouling surfaces

Zhanhua Wang et al.

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Synthesis and Antibacterial Study of Sulfobetaine/Quaternary Ammonium-Modified Star-Shaped Poly[2-(dimethylamino)ethyl methacrylate]-Based Copolymers with an Inorganic Core

Yuji Pu et al.

BIOMACROMOLECULES (2017)

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Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility

Yuemei Han et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings

Volkan Yesilyurt et al.

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Preparation and characterization of protein-resistant hydrogels for soft contact lens applications via radical copolymerization involving a zwitterionic sulfobetaine comonomer

Wanlu Zhang et al.

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Machine Learning for Silver Nanoparticle Electron Transfer Property Prediction

Baichuan Sun et al.

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Antifouling zwitterionic hydrogel coating improves hemocompatibility of activated carbon hemoadsorbent

Nana Cai et al.

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Substituted Polyesters by Thiol-Ene Modification: Rapid Diversification for Therapeutic Protein Stabilization

Emma M. Pelegri-O'Day et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Stable and Functionalizable Quantum Dots with a Thin Zwitterionic Carboxybetaine Layer

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Preparation of Vascular Endothelial Cadherin Loaded-Amphoteric Copolymer Decorated Coronary Stents for Anticoagulation and Endothelialization

Huan Chen et al.

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Poly(ectoine) Hydrogels Resist Nonspecific Protein Adsorption

Priyesh Jain et al.

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Dendrimers meet zwitterions: development of a unique antifouling nanoplatform for enhanced blood pool, lymph node and tumor CT imaging

Zhijuan Xiong et al.

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DNA protection by ectoine from ionizing radiation: molecular mechanisms

Marc Benjamin Hahn et al.

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How to manipulate the upper critical solution temperature (UCST)?

Jukka Niskanen et al.

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Effect of the zwitterion structure on the thermo-responsive behaviour of poly(sulfobetaine methacrylates)

Viet Hildebrand et al.

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Inflammation and metabolism in tissue repair and regeneration

Sabine A. Eming et al.

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Cell-Penetrating Peptides: From Basic Research to Clinics

Giulia Guidotti et al.

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Simple Protein Modification Using Zwitterionic Polymer to Mitigate the Bioactivity Loss of Conjugated Insulin

Jinbing Xie et al.

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Zwitterion-coated ultrasmall iron oxide nanoparticles for enhanced T1-weighted magnetic resonance imaging applications

Dan Ma et al.

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Water-repairable zwitterionic polymer coatings for anti-biofouling surfacese

Zhanhua Wang et al.

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One-step synthesis of an antibacterial and pro-healing wound dressing that can treat wound infections

Yingnan Zhu et al.

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Towards clinically translatable in vivo nanodiagnostics

Seung-min Park et al.

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Machine Learning and Data Mining Methods in Diabetes Research

Ioannis Kavakiotis et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2017)

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Marine antifouling performance of polymer coatings incorporating zwitterions

Claudia Ventura et al.

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Exploring the Potential of Biocompatible Osmoprotectants as Highly Efficient Cryoprotectants

Jing Yang et al.

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Macrofouling induced localized corrosion of stainless steel in Singapore seawater

Daniel J. Blackwood et al.

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Paper Sensor Coated with a Poly(carboxybetaine)-Multiple DOPA Conjugate via Dip-Coating for Biosensing in Complex Media

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Zwitterionic sulfobetaine polymer-immobilized surface by simple tyrosinase-mediated grafting for enhanced antifouling property

Ho Joon Kwon et al.

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Ultrathin Cell-Membrane-Mimic Phosphorylcholine Polymer Film Coating Enables Large Improvements for InVivo Electrochemical Detection

Xiaomeng Liu et al.

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Superdurable Coating Fabricated from a Double-Sided Tape with Long Term Zero Bacterial Adhesion

Wei Wang et al.

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A Coating-Free Nonfouling Polymeric Elastomer

Hsiang-Chieh Hung et al.

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Cellular uptake of nanoparticles: journey inside the cell

Shahed Behzadi et al.

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Zwitterionic Nanocarrier Surface Chemistry Improves siRNA Tumor Delivery and Silencing Activity Relative to Polyethylene Glycol

Meredith A. Jackson et al.

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Amphiphilic Antifogging/Anti-Icing Coatings Containing POSS-PDMAEMA-b-PSBMA

Chuan Li et al.

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Natural zwitterionic L-Carnitine as efficient cryoprotectant for solvent-free cell cryopreservation

Hongwen Zhai et al.

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Contribution of Charges in Polyvinyl Alcohol Networks to Marine Antifouling

Wufang Yang et al.

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Superhydrophilic In-Situ-Cross-Linked Zwitterionic Polyelectrolyte/PVDF-Blend Membrane for Highly Efficient Oil/Water Emulsion Separation

Yuzhang Zhu et al.

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Proton-sensing transistor systems for detecting ion leakage from plasma membranes under chemical stimuli

Yuki Imaizumi et al.

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An overview of the role of neutrophils in innate immunity, inflammation and host-biomaterial integration

Gretchen S. Selders et al.

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Polymer Coating Materials and Their Fouling Release Activity: A Cheminformatics Approach to Predict Properties

Bakhtiyor Rasulev et al.

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The Hydration Properties of Carboxybetaine Zwitterion Brushes

Hongbo Du et al.

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Enhanced Oral Delivery of Protein Drugs Using Zwitterion-Functionalized Nanoparticles to Overcome both the Diffusion and Absorption Barriers

Wei Shan et al.

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Physical Cross-Linking Starch-Based Zwitterionic Hydrogel Exhibiting Excellent Biocompatibility, Protein Resistance, and Biodegradability

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Incorporating Zwitterionic Graphene Oxides into Sodium Alginate Membrane for Efficient Water/Alcohol Separation

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Zwitterionic-Modified Starch-Based Stealth Micelles for Prolonging Circulation Time and Reducing Macrophage Response

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ACS APPLIED MATERIALS & INTERFACES (2016)

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In Situ Clickable Zwitterionic Starch-Based Hydrogel for 3D Cell Encapsulation

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Adsorption and Unfolding of a Single Protein Triggers Nanoparticle Aggregation

Sergio Dominguez-Medina et al.

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Significantly reduced adsorption and activation of blood components in a membrane oxygenator system coated with crosslinkable zwitterionic copolymer

Yan-Bing Wang et al.

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Development of anti-biofouling interface on hydroxyapatite surface by coating zwitterionic MPC polymer containing calcium-binding moieties to prevent oral bacterial adhesion

Sunah Kang et al.

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Zwitterionic nanogels crosslinked by fluorescent carbon dots for targeted drug delivery and simultaneous bioimaging

Wenchen Li et al.

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Synthesis and characterization of a zwitterionic hydrogel blend with low coefficient of friction

Allen O. Osaheni et al.

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Achieving low-fouling surfaces with oppositely charged polysaccharides via LBL assembly

Yuping Wei et al.

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Molecular level studies on interfacial hydration of zwitterionic and other antifouling polymers in situ

Chuan Leng et al.

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Intestinal permeation enhancers for oral peptide delivery

Sam Maher et al.

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Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population

Qi Yang et al.

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Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals

Bing-Mae Chen et al.

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Ectoine as a promising protective agent in humans and animals

Adam Bownik et al.

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Membrane Translocation and Organelle-Selective Delivery Steered by Polymeric Zwitterionic Nanospheres

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Development of Long-Circulating Zwitterionic Cross-Linked Micelles for Active-Targeted Drug Delivery

Weifeng Lin et al.

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Hierarchical Polymer Brushes with Dominant Antibacterial Mechanisms Switching from Bactericidal to Bacteria Repellent

Shunjie Yan et al.

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Silicone hydrogels grafted with natural amino acids for ophthalmological application

Chen Xu et al.

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Butyrylcholinesterase nanocapsule as a long circulating bioscavenger with reduced immune response

Peng Zhang et al.

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In situ growth of a C-terminal interferon-alpha conjugate of a phospholipid polymer that outperforms PEGASYS in cancer therapy

Jin Hu et al.

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Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation

Peng Zhang et al.

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Fabrication of electro-neutral nanofiltration membranes at neutral pH with antifouling surface via interfacial polymerization from a novel zwitterionic amine monomer

Tianyi Ma et al.

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Antifouling pseudo-zwitterionicpoly(vinylidene fluoride) membranes with efficient mixed-charge surface grafting via glow dielectric barrier discharge plasma-induced copolymerization

Antoine Venault et al.

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PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs

Peter L. Turecek et al.

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Unveiling the Amphiphilic Nature of TMAO by Vibrational Sum Frequency Generation Spectroscopy

Tatsuhiko Ohto et al.

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Amino Acid-Based Zwitterionic Polymer Surfaces Highly Resist Long-Term Bacterial Adhesion

Qingsheng Liu et al.

LANGMUIR (2016)

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pH-Sensitive Poly(histidine methacrylamide)

Huifeng Wang et al.

LANGMUIR (2016)

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Molecular Dynamics Simulations of a Poly(ethylene glycol)-Grafted Polyamide Membrane and Its Interaction with a Calcium Alginate Gel

Yuan Xiang et al.

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Antifouling Zwitterionic Coating via Electrochemically Mediated Atom Transfer Radical Polymerization on Enzyme-Based Glucose Sensors for Long-Time Stability in 37 °C Serum

Yichuan Hu et al.

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Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins

Sheng Liang et al.

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Chemical conjugation of zwitterionic polymers protects immunogenic enzyme and preserves bioactivity without polymer-specific antibody response

Sijun Liu et al.

Nano Today (2016)

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Emerging understanding of the protein corona at the nano-bio interfaces

Morteza Mahmoudi et al.

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Biofilms: an emergent form of bacterial life

Hans-Curt Flemming et al.

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Enzyme Biosensors for Biomedical Applications: Strategies for Safeguarding Analytical Performances in Biological Fluids

Gaia Rocchitta et al.

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Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response

Ajaykumar Vishwakarma et al.

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Electroactive poly(sulfobetaine-3,4-ethylenedioxythiophene) (PSBEDOT) with controllable antifouling and antimicrobial properties

Bin Cao et al.

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Harnessing isomerization-mediated manipulation of nonspecific cell/matrix interactions to reversibly trigger and suspend stem cell differentiation

Tao Bai et al.

CHEMICAL SCIENCE (2016)

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Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma

Fang Sun et al.

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A zwitterionic gel electrolyte for efficient solid-state supercapacitors

Xu Peng et al.

NATURE COMMUNICATIONS (2016)

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Carbon-Quantum-Dots-Loaded Mesoporous Silica Nanocarriers with pH-Switchable Zwitterionic Surface and Enzyme-Responsive Pore-Cap for Targeted Imaging and Drug Delivery to Tumor

Zhongning Liu et al.

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The effects of poly(zwitterions)s versus poly(ethylene glycol) surface coatings on the biodistribution of protein nanoparticles

Jing Wang et al.

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Zwitterionic hydrogels promote skin wound healing

Yingnan Zhu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2016)

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Zwitterionic nanocomposite hydrogels as effective wound dressings

Kang-Ting Huang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2016)

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Analysis of nanoparticle delivery to tumours

Stefan Wilhelm et al.

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Natural zwitterionic betaine enables cells to survive ultrarapid cryopreservation

Jing Yang et al.

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Safety concerns over the use of intestinal permeation enhancers: A mini-review

Fiona McCartney et al.

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Development of Robust and Recoverable Ultralow-Fouling Coatings Based on Poly(carboxybetaine) Ester Analogue

Guangzhi Wang et al.

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Applying Thermosettable Zwitterionic Copolymers as General Fouling-Resistant and Thermal-Tolerant Biomaterial Interfaces

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Probing the Surface Hydration of Nonfouling Zwitterionic and PEG Materials in Contact with Proteins

Chuan Leng et al.

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Sulfobetaine-Vinylimidazole Block Copolymers: A Robust Quantum Dot Surface Chemistry Expanding Bioimaging's Horizons

Mariana Tasso et al.

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Stealth Surface Modification of Surface-Enhanced Raman Scattering Substrates for Sensitive and Accurate Detection in Protein Solutions

Fang Sun et al.

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Cleaning of Oil Fouling with Water Enabled by Zwitterionic Polyelectrolyte Coatings: Overcoming the Imperative Challenge of Oil-Water Separation Membranes

Ke He et al.

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Surface and Interfacial Engineering of Iron Oxide Nanoplates for Highly Efficient Magnetic Resonance Angiography

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EKylation: Addition of an Alternating-Charge Peptide Stabilizes Proteins

Erik J. Liu et al.

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Surface protonation/deprotonation controlled instant affinity switch of nano drug vehicle (NDV) for pH triggered tumor cell targeting

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Site-Specific Zwitterionic Polymer Conjugates of a Protein Have Long Plasma Circulation

Somnath Bhattacharjee et al.

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Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications

Xiangkui Ren et al.

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Dropwise condensation theory revisited Part II. Droplet nucleation density and condensation heat flux

Xiuliang Liu et al.

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER (2015)

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Critical update on 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer science

Tatsuro Goda et al.

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Probing the Surface Hydration of Nonfouling Zwitterionic and Poly(ethylene glycol) Materials with Isotopic Dilution Spectroscopy

Chuan Leng et al.

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A Multifunctional Polymer Combining the Imidazole and Zwitterion Motifs as a Biocompatible Compact Coating for Quantum Dots

Wentao Wang et al.

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Structure-Function Relationships of a Tertiary Amine-Based Polycarboxybetaine

Chen-Jung Lee et al.

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Salt-Responsive Zwitterionic Polymer Brushes with Tunable Friction and Antifouling Properties

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LANGMUIR (2015)

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Zwitterionic Antifouling Coatings for the Purification of High-Salinity Shale Gas Produced Water

Rong Yang et al.

LANGMUIR (2015)

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Preparation of compact biocompatible quantum dots using multicoordinating molecular-scale ligands based on a zwitterionic hydrophilic motif and lipoic acid anchors

Naiqian Zhan et al.

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Zwitterionic gel encapsulation promotes protein stability, enhances pharmacokinetics, and reduces immunogenicity

Peng Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Zwitterionic chitosan-silica-PVA hybrid ultrafiltration membranes for protein separation

Guan Liu et al.

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Extracorporeal Membrane Oxygenation-Hemostatic Complications

Deirdre A. Murphy et al.

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Zwitterionic copolymer-based and hydrogen bonding-strengthened self-healing hydrogel

He Liu et al.

RSC ADVANCES (2015)

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Innate Immunity and Biomaterials at the Nexus: Friends or Foes

Susan N. Christo et al.

BIOMED RESEARCH INTERNATIONAL (2015)

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Green materials science and engineering reduces biofouling: approaches for medical and membrane-based technologies

Kerianne M. Dobosz et al.

FRONTIERS IN MICROBIOLOGY (2015)

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Development of zwitterionic polyurethanes with multi-shape memory effects and self-healing properties

Shaojun Chen et al.

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Biocompatible long-circulating star carboxybetaine polymers

Weifeng Lin et al.

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Molecular Understanding and Design of Zwitterionic Materials

Qing Shao et al.

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The Langmuir isotherm: A commonly applied but misleading approach for the analysis of protein adsorption behavior

Robert A. Latour

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Ultrathin Zwitterionic Coatings for Roughness-Independent Underwater Superoleophobicity and Gravity-Driven Oil-Water Separation

Rong Yang et al.

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Introducing Mixed-Charge Copolymers As Wound Dressing Biomaterials

Jheng-Fong Jhong et al.

ACS APPLIED MATERIALS & INTERFACES (2014)

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Building an Antifouling Zwitterionic Coating on Urinary Catheters Using an Enzymatically Triggered Bottom-Up Approach

Carlos Diaz Blanco et al.

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Bacterial Resistance Control on Mineral Surfaces of Hydroxyapatite and Human Teeth via Surface Charge-Driven Antifouling Coatings

Antoine Venault et al.

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Cell-Penetrating Peptides: Design, Synthesis, and Applications

Dana Maria Copolovici et al.

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Two amino acid-based superlow fouling polymers: Poly(lysine methacrylamide) and poly(ornithine methacrylamide)

Qingsheng Liu et al.

ACTA BIOMATERIALIA (2014)

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Synergistic Prevention of Biofouling in Seawater Desalination by Zwitterionic Surfaces and Low-Level Chlorination

Rong Yang et al.

ADVANCED MATERIALS (2014)

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25th Anniversary Article: Designer Hydrogels for Cell Cultures: A Materials Selection Guide

Julian Thiele et al.

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25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine

Nasim Annabi et al.

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Cellulose Paper Sensors Modified with Zwitterionic Poly(carboxybetaine) for Sensing and Detection in Complex Media

Yongheng Zhu et al.

ANALYTICAL CHEMISTRY (2014)

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Restraint of the Differentiation of Mesenchymal Stem Cells by a Nonfouling Zwitterionic Hydrogel

Tao Bai et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

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Protein Interactions with Polymer Coatings and Biomaterials

Qiang Wei et al.

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A Robust Graft-to Strategy To Form Multifunctional and Stealth Zwitterionic Polymer-Coated Mesoporous Silica Nanoparticles

Yongheng Zhu et al.

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Optical imaging of fibrin deposition to elucidate participation of mast cells in foreign body responses

Yi-Ting Tsai et al.

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The OPEP protein model: from single molecules, amyloid formation, crowding and hydrodynamics to DNA/RNA systems

Fabio Sterpone et al.

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Sulfobetaine-based polymer brushes in marine environment: Is there an effect of the polymerizable group on the antifouling performance?

Robert Quintana et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2014)

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Antifouling, adsorption and reversible flux properties of zwitterionic grafted PVDF membrane prepared via physisorbed free radical polymerization

Qing Zhou et al.

DESALINATION (2014)

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Improved Antifouling Properties of Poly(vinyl chloride) Ultrafiltration Membranes via Surface Zwitterionicalization

Junao Zhu et al.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2014)

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Thermoresponsive/Low-Fouling Zwitterionic Hydrogel for Controlled Drug Release

Renchang Zeng et al.

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Polyampholyte polymers as a versatile zwitterionic biomaterial platform

Matthew Bernards et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2014)

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Hemocompatibility of pseudozwitterionic polymer brushes with a systematic well-defined charge-bias control

Jheng-Fong Jhong et al.

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Amino acid-based zwitterionic polymers: antifouling properties and low cytotoxicity

Wenchen Li et al.

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Recent advances of zwitterionic carboxybetaine materials and their derivatives

Bin Cao et al.

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Zwitterionic hyperbranched polyester functionalized cardiovascular stent and its biocompatibility

Xiaobo Wang et al.

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Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA

Yan Li et al.

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Hemocompatibility and film stability improvement of crosslinkable MPC copolymer coated polypropylene hollow fiber membrane

Yan-Bing Wang et al.

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Fouling behavior of zwitterionic membranes: Impact of electrostatic and hydrophobic interactions

Mahsa Hadidi et al.

JOURNAL OF MEMBRANE SCIENCE (2014)

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Influence of Charged Groups on the Properties of Zwitterionic Moieties: A Molecular Simulation Study

Qing Shao et al.

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Simulations of Protein Aggregation: Insights from Atomistic and Coarse-Grained Models

Alex Morriss-Andrews et al.

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Bioinspired Bottle-Brush Polymer Exhibits Low Friction and Amontons-like Behavior

Xavier Banquy et al.

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Zwitterionic Poly(amino acid methacrylate) Brushes

Abdullah M. Alswieleh et al.

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Development of Zwitterionic Polymer-Based Doxorubicin Conjugates: Tuning the Surface Charge To Prolong the Circulation and Reduce Toxicity

Zhen Wang et al.

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Antifouling Gold Surfaces Grafted with Aspartic Acid and Glutamic Acid Based Zwitterionic Polymer Brushes

Wenchen Li et al.

LANGMUIR (2014)

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Biologically Inspired Stealth Peptide-Capped Gold Nanoparticles

Ann K. Nowinski et al.

LANGMUIR (2014)

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One-pot synthesis of responsive sulfobetaine nanoparticles by RAFT polymerisation: the effect of branching on the UCST cloud point

Helen Willcock et al.

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Polymer brush coatings for combating marine biofouling

Wen Jing Yang et al.

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Advances in skin grafting and treatment of cutaneous wounds

Bryan K. Sun et al.

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Zwitterionic-Coated Stealth Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System

Karina Pombo Garcia et al.

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Liquid-phase extraction coupled with metal-organic frameworks-based dispersive solid phase extraction of herbicides in peanuts

Na Li et al.

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Reversibly switchable polymer with cationic/zwitterionic/anionic behavior through synergistic protonation and deprotonation

Harihara Subramanian Sundaram et al.

CHEMICAL SCIENCE (2014)

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Development of nonfouling polypeptides with uniform alternating charges by polycondensation of the covalently bonded dimer of glutamic acid and lysine

Qinghua Yang et al.

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Peptide-Modified Zwitterionic Porous Hydrogels for Endothelial Cell and Vascular Engineering

Chih-Yeh Lin et al.

BIORESEARCH OPEN ACCESS (2014)

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Development of Nonstick and Drug-Loaded Wound Dressing Based on the Hydrolytic Hydrophobic Poly(carboxybetaine) Ester Analogue

Fangqin Ji et al.

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Charge Tunable Zwitterionic Polyampholyte Layers Formed in Cyclic Olefin Copolymer Microchannels through Photochemical Graft Polymerization

Xianglu Peng et al.

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Engineered Iron-Oxide-Based Nanoparticles as Enhanced T1 Contrast Agents for Efficient Tumor Imaging

Zijian Zhou et al.

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Directly Functionalizable Surface Platform for Protein Arrays in Undiluted Human Blood Plasma

Norman D. Brault et al.

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Amino Acid-Based Zwitterionic Poly(serine methacrylate) as an Antifouling Material

Qingsheng Liu et al.

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Engineering Buffering and Hydrolytic or Photolabile Charge Shifting in a Polycarboxybetaine Ester Gene Delivery Platform

Andrew Sinclair et al.

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The impact of structure on elasticity, switchability, stability and functionality of an all-in-one carboxybetaine elastomer

Bin Cao et al.

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Bioinspired phosphorylcholine-modified polyplexes as an effective strategy for selective uptake and transfection of cancer cells

Lina Chen et al.

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Synthesis of biomimetic hyperbranched zwitterionic polymers as targeting drug delivery carriers

Xiaohong Wang et al.

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(3-glycidoxypropyl) Trimethoxy silane induced switchable zwitterionic membrane with high protein capture and separation properties

Tina Chakrabarty et al.

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Investigations on the Interactions of Proteins with Polyampholyte-Coated Magnetite Nanoparticles

Tao Zhao et al.

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Charged Gold Nanoparticles with Essentially Zero Serum Protein Adsorption in Undiluted Fetal Bovine Serum

Avinash K. Murthy et al.

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Controlled pH Stability and Adjustable Cellular Uptake of Mixed-Charge Nanoparticles

Pramod P. Pillai et al.

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Passive Tumor Targeting of Renal-Clearable Luminescent Gold Nanoparticles: Long Tumor Retention and Fast Normal Tissue Clearance

Jinbin Liu et al.

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Multidentate Zwitterionic Ligands Provide Compact and Highly Biocompatible Quantum Dots

Naiqian Zhan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

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Risk of venous thromboembolism associated with peripherally inserted central catheters: a systematic review and meta-analysis

Vineet Chopra et al.

LANCET (2013)

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All charged up about implanted biomaterials

David W. Grainger

NATURE BIOTECHNOLOGY (2013)

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Zwitterionic hydrogels implanted in mice resist the foreign-body reaction

Lei Zhang et al.

NATURE BIOTECHNOLOGY (2013)

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Physical hydrogels composed of polyampholytes demonstrate high toughness and viscoelasticity

Tao Lin Sun et al.

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Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

Anna Salvati et al.

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Bacterial flagella explore microscale hummocks and hollows to increase adhesion

Ronn S. Friedlander et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Hydrolytic Cationic Ester Microparticles for Highly Efficient DNA Vaccine Delivery

Lei Zhang et al.

SMALL (2013)

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Accelerated Materials Design of Lithium Superionic Conductors Based on First-Principles Calculations and Machine Learning Algorithms

Koji Fujimura et al.

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Switchable Antimicrobial and Antifouling Hydrogels with Enhanced Mechanical Properties

Bin Cao et al.

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Blood compatibility of a new zwitterionic bare metal stent with hyperbranched polymer brushes

Xiaobo Wang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2013)

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Neutrophil recruitment and function in health and inflammation

Elzbieta Kolaczkowska et al.

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Softer Zwitterionic Nanogels for Longer Circulation and Lower Splenic Accumulation

Lei Zhang et al.

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Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor

You-Yong Yuan et al.

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Controlled Hierarchical Architecture in Surface-initiated Zwitterionic Polymer Brushes with Structurally Regulated Functionalities

Chun-Jen Huang et al.

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Mucus Penetrating Nanoparticles: Biophysical Tool and Method of Drug and Gene Delivery

Laura M. Ensign et al.

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Zwitterionic Polymer-Based Platform with Two-Layer Architecture for Ultra Low Fouling and High Protein Loading

Chun-Jen Huang et al.

ANALYTICAL CHEMISTRY (2012)

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Reversibly Switching the Function of a Surface between Attacking and Defending against Bacteria

Zhiqiang Cao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

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Zwitterionic sulfobetaine-grafted poly(vinylidene fluoride) membrane surface with stably anti-protein-fouling performance via a two-step surface polymerization

Qian Li et al.

APPLIED SURFACE SCIENCE (2012)

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The impact and control of biofouling in marine aquaculture: a review

Isla Fitridge et al.

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Two-Layer Architecture Using Atom Transfer Radical Polymerization for Enhanced Sensing and Detection in Complex Media

Norman D. Brault et al.

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Synchronizing nonfouling and antimicrobial properties in a zwitterionic hydrogel

Luo Mi et al.

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Direct cell encapsulation in biodegradable and functionalizable carboxybetaine hydrogels

Hsiu-Wen Chien et al.

BIOMATERIALS (2012)

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Biomimetic hydration lubrication with various polyelectrolyte layers on cross-linked polyethylene orthopedic bearing materials

Masayuki Kyomoto et al.

BIOMATERIALS (2012)

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The effect of lightly crosslinked poly(carboxybetaine) hydrogel coating on the performance of sensors in whole blood

Wei Yang et al.

BIOMATERIALS (2012)

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Fouling Release Coatings: A Nontoxic Alternative to Biocidal Antifouling Coatings

Marlene Lejars et al.

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Hydration lubrication: exploring a new paradigm

Anastasya Gaisinskaya et al.

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Assessment of the Antifouling Properties of Polyzwitterions from Free Energy Calculations by Molecular Dynamics Simulations

Ryo Nagumo et al.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2012)

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Different effects of zwitterion and ethylene glycol on proteins

Qing Shao et al.

JOURNAL OF CHEMICAL PHYSICS (2012)

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Using zwitterionic amino acid L-DOPA to modify the surface of thin film composite polyamide reverse osmosis membranes to increase their fouling resistance

Sara Azari et al.

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Grafting zwitterionic brush on the surface of PVDF membrane using physisorbed free radical grafting technique

Mi-Zi Li et al.

JOURNAL OF MEMBRANE SCIENCE (2012)

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High Viability of Cells Encapsulated in Degradable Poly(carboxybetaine) Hydrogels

Hsiu-Wen Chien et al.

LANGMUIR (2012)

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Superhydrophilic Zwitterionic Polymers Stabilize Liposomes

Zhiqiang Cao et al.

LANGMUIR (2012)

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Facile Preparation of Zwitterion-Stabilized Superparamagnetic Iron Oxide Nanoparticles (ZSPIONs) as an MR Contrast Agent for in Vivo Applications

Dongkyu Kim et al.

LANGMUIR (2012)

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Ultrathin Antifouling Coatings with Stable Surface Zwitterionic Functionality by Initiated Chemical Vapor Deposition (iCVD)

Rong Yang et al.

LANGMUIR (2012)

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Compact Zwitterion-Coated Iron Oxide Nanoparticles for Biological Applications

He Wei et al.

NANO LETTERS (2012)

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Super-hydrophilic zwitterionic poly(carboxybetaine) and amphiphilic non-ionic poly(ethylene glycol) for stealth nanoparticles

Zhiqiang Cao et al.

NANO TODAY (2012)

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Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity

Andrew J. Keefe et al.

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Molecular dynamics simulations for microscopic behavior of water molecules in the vicinity of zwitterionic self-assembled monolayers

Ryo Nagumo et al.

POLYMER JOURNAL (2012)

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Cell membrane-inspired phospholipid polymers for developing medical devices with excellent biointerfaces

Yasuhiko Iwasaki et al.

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS (2012)

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Vascular Catheters with a Nonleaching Poly-Sulfobetaine Surface Modification Reduce Thrombus Formation and Microbial Attachment

Roger S. Smith et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

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Decoding nonspecific interactions from nature

Andrew D. White et al.

CHEMICAL SCIENCE (2012)

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The second skin: ecological role of epibiotic biofilms on marine organisms

Martin Wahl et al.

FRONTIERS IN MICROBIOLOGY (2012)

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The betaine-GABA transporter (BGT1, slc6a12) is predominantly expressed in the liver and at lower levels in the kidneys and at the brain surface

Y. Zhou et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2012)

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Effect of hydrophilic polymer conjugation on heat-induced conformational changes in a protein

Ji-Hun Seo et al.

ACTA BIOMATERIALIA (2011)

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A Thermoresponsive Antimicrobial Wound Dressing Hydrogel Based on a Cationic Betaine Ester

Luo Mi et al.

ADVANCED FUNCTIONAL MATERIALS (2011)

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Manipulating Sticky and Non-Sticky Properties in a Single Material

Zhiqiang Cao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

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Luminescent Gold Nanoparticles with Efficient Renal Clearance

Chen Zhou et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

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Environmental drivers of Atlantic salmon behaviour in sea-cages: A review

Frode Oppedal et al.

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Poly(carboxybetaine methacrylamide)-Modified Nanoparticles: A Model System for Studying the Effect of Chain Chemistry on Film Properties, Adsorbed Protein Conformation, and Clot Formation Kinetics

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Thermoresponsive Polypeptides from Pegylated Poly-L-glutamates

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Surface Modification with Poly(sulfobetaine methacrylate-co-acrylic acid) To Reduce Fibrinogen Adsorption, Platelet Adhesion, and Plasma Coagulation

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Functionalizable and nonfouling zwitterionic carboxybetaine hydrogels with a carboxybetaine dimethacrylate crosslinker

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Multifunctional and degradable zwitterionic nanogels for targeted delivery, enhanced MR imaging, reduction-sensitive drug release, and renal clearance

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Zwitterionic poly(carboxybetaine) hydrogels for glucose biosensors in complex media

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Surface-Tethered Zwitterionic Ultrathin Antifouling Coatings on Reverse Osmosis Membranes by Initiated Chemical Vapor Deposition

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Anti-biofouling properties of amphiphilic phosphorylcholine polymer films

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Polyzwitterionic brushes: Extreme lubrication by design

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Grafting short-chain amino acids onto membrane surfaces to resist protein fouling

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Molecular Dynamics Simulation Study of Ion Interactions with Zwitterions

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Water Mobility: A Bridge between the Hofmeister Series of Ions and the Friction of Zwitterionic Surfaces in Aqueous Environments

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Importance of Sialic Acid Residues Illuminated by Live Animal Imaging Using Phosphorylcholine Self-Assembled Monolayer-Coated Quantum Dots

Tatsuya Ohyanagi et al.

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Enhancement of Cellular Uptake and Antitumor Efficiencies of Micelles with Phosphorylcholine

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Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing

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Ultralow-Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications

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Nanoparticles for Drug Delivery Prepared from Amphiphilic PLGA Zwitterionic Block Copolymers with Sharp Contrast in Polarity between Two Blocks

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Modulation of barnacle (Balanus amphitrite Darwin) cyprid settlement behavior by sulfobetaine and carboxybetaine methacrylate polymer coatings

Nick Aldred et al.

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Super-hydrophilic silicone hydrogels with interpenetrating poly(2-methacryloyloxyethyl phosphorylcholine) networks

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Mediating high levels of gene transfer without cytotoxicity via hydrolytic cationic ester polymers

Louisa R. Carr et al.

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Functionalizable and ultra-low fouling zwitterionic surfaces via adhesive mussel mimetic linkages

Changlu Gao et al.

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Imaging and cell targeting characteristics of magnetic nanoparticles modified by a functionalizable zwitterionic polymer with adhesive 3,4-dihydroxyphenyl-L-alanine linkages

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Cell-penetrating macromolecules: Direct penetration of amphipathic phospholipid polymers across plasma membrane of living cells

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The relationship between platelet adhesion on surfaces and the structure versus the amount of adsorbed fibrinogen

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Zwitterionic phosphorylcholine as a better ligand for gold nanorods cell uptake and selective photothermal ablation of cancer cells

Wenbo Zhou et al.

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Simple surface modification of a titanium alloy with silanated zwitterionic phosphorylcholine or sulfobetaine modifiers to reduce thrombogenicity

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Biofilm formation and the food industry, a focus on the bacterial outer surface

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Characterization of the in vitro macrophage response and in vivo host response to poly(ethylene glycol)-based hydrogels

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Strategies for controlling biofouling in membrane filtration systems: challenges and opportunities

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Effect of sludge characteristics on membrane fouling in membrane bioreactors

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Impact of glycoprotein VI and platelet adhesion on atherosclerosis-A possible role of fibronectin

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Difference in Hydration between Carboxybetaine and Sulfobetaine

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Small and Stable Sulfobetaine Zwitterionic Quantum Dots for Functional Live-Cell Imaging

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Integrated Antimicrobial and Nonfouling Hydrogels to Inhibit the Growth of Planktonic Bacterial Cells and Keep the Surface Clean

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Functionalizable and Ultrastable Zwitterionic Nanogels

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Hemocompatible Mixed-Charge Copolymer Brushes of Pseudozwitterionic Surfaces Resistant to Nonspecific Plasma Protein Fouling

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Synthetic polymer coatings for long-term growth of human embryonic stem cells

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Rapid translocation of nanoparticles from the lung airspaces to the body

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Design considerations for tumour-targeted nanoparticles

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Surface hydration: Principles and applications toward low-fouling/nonfouling biomaterials

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Proangiogenic scaffolds as functional templates for cardiac tissue engineering

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An overview of coagulation disorders in cancer patients

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Barrier properties of mucus

Richard A. Cone

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Phosphorylcholine Impairs Susceptibility to Biofilm Formation of Hydrogel Contact Lenses

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Label-free detection of cancer biomarker candidates using surface plasmon resonance imaging

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Extracorporeal Life Support Registry Report 2008: Neonatal and Pediatric Cardiac Cases

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A small diameter, fibrous vascular conduit generated from a poly(ester urethane)urea and phospholipid polymer blend

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Conformational recovery and preservation of protein nature from heat-induced denaturation by water-soluble phospholipid polymer conjugation

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Functionalizable and ultra stable nanoparticles coated with zwitterionic poly(carboxybetaine) in undiluted blood serum

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Ultra-low fouling peptide surfaces derived from natural amino acids

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Zwitterionic carboxybetaine polymer surfaces and their resistance to long-term biofilm formation

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Functionalizable surface platform with reduced nonspecific protein adsorption from full blood plasma-Material selection and protein immobilization optimization

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Intraperitoneal administration of paclitaxel solubilized with poly(2-methacryloxyethyl phosphorylcholine-co n-butyl methacrylate) for peritoneal dissemination of gastric cancer

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Nanocarriers' entry into the cell: relevance to drug delivery

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Quantitative and Qualitative Evaluation of Adsorption/Desorption of Bovine Serum Albumin on Hydrophilic and Hydrophobic Surfaces

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Polysulfobetaine-Grafted Surfaces as Environmentally Benign Ultralow Fouling Marine Coatings

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Anti-Biofouling Properties of Polymers with a Carboxybetaine Moiety

Susumu Tada et al.

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Lubrication at Physiological Pressures by Polyzwitterionic Brushes

Meng Chen et al.

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A new avenue to nonfouling materials

Shengfu Chen et al.

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Ultralow fouling and functionalizable surface chemistry based on a zwitterionic polymer enabling sensitive and specific protein detection in undiluted blood plasma

Hana Vaisocherova et al.

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A Switchable Biocompatible Polymer Surface with Self-Sterilizing and Nonfouling Capabilities

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Poly(2-methacryloyloxyethyl phosphorylcholine) for Protein Conjugation

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Nonfouling Behavior of Polycarboxybetaine-Grafted Surfaces: Structural and Environmental Effects

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Zwitterionic polymers exhibiting high resistance to nonspecific protein adsorption from human serum and plasma

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The hydrolysis of cationic polycarboxybetaine esters to zwitterionic polycarboxybetaines with controlled properties

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Blood compatibility of surfaces with superlow protein adsorption

Zheng Zhang et al.

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Ultra low fouling zwitterionic polymers with a biomimetic adhesive group

Guozhu Li et al.

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The multifunctional role of ectoine as a natural cell protectant

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Effect of 2-methacryloyloxyethyl phosphorylcholine concentration on photo-induced graft polymerization of polyethylene in reducing the wear of orthopaedic bearing surface

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The MARTINI coarse-grained force field: Extension to proteins

Luca Monticelli et al.

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Ultralow Fouling Zwitterionic Polymers Grafted from Surfaces Covered with an Initiator via an Adhesive Mussel Mimetic Linkage

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A Highly stable nonbiofouling surface with well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion

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Molecular simulation studies of protein interactions with zwitterionic phosphorylcholine self-assembled monolayers in the presence of water

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Protein-resistant poly(ethylene oxide)-grafted surfaces: Chain density-dependent multiple mechanisms of action

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Structure of water incorporated in amphoteric polymer thin films as revealed by FT-IR spectroscopy

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Nonfouling polymer brushes via surface-initiated, two-component atom transfer radical polymerization

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Thickness-dependent properties of polyzwitterionic brushes

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Hydration of phosphorylcholine groups attached to highly swollen polymer hydrogels studied by thermal analysis

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Foreign body reaction to biomaterials

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Exploring the full spectrum of macrophage activation

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Aggregation-resistant water-soluble gold nanoparticles

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Compact cysteine-coated CdSe(ZnCdS) quantum dots for in vivo applications

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Reduced foreign body response at nitric oxide-releasing subcutaneous implants

Evan M. Hetrick et al.

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Renal clearance of quantum dots

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Inhibition of bacterial adhesion and biofilm formation on zwitterionic surfaces

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Molecular simulation studies of nanoscale friction between phosphorylcholine self-assembled monolayer surfaces: Correlation between surface hydration and friction

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Preclinical biocompatibility assessment of the EVAHEART ventricular assist device: Coating comparison and platelet activation

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Adsorption, lubrication, and wear of lubricin on model surfaces: Polymer brush-like behavior of a glycoprotein

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Coarse-grained protein molecular dynamics simulations

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Bacterial cell attachment, the beginning of a biofilm

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Superlow fouling sulfobetaine and carboxybetaine polymers on glass slides

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Molecular simulation studies of the structure of phosphorylcholine self-assembled monolayers

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Strong resistance of a thin crystalline layer of balanced charged groups to protein adsorption

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Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant

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Surface grafted sulfobetaine polymers via atom transfer radical polymerization as superlow fouling coatings

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Soft contact lens biomaterials from bioinspired phospholipid polymers

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Non-biofouling materials prepared by atom transfer radical polymerization grafting of 2-methacryloloxyethyl phosphorylcholine: Separate effects of graft density and chain length on protein repulsion

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UCST wetting transitions of polyzwitterionic brushes driven by self-association

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Correlation between the structure of water in the vicinity of carboxybetaine polymers and their blood-compatibility

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Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: Insights into nonfouling properties of zwitterionic materials

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In uremia, plasma levels of anti-protein C and anti-protein S antibodies are associated with thrombosis

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Design of functional hollow fiber membranes modified with phospholipid polymers for application in total hemopurification system

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Adsorption of fibrinogen and lysozyme on silicon grafted with poly(2-methacryloyloxyethyl phosphorylcholine) via surface-initiated atom transfer radical polymerization

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Self-assembled biomimetic monolayers using phospholipid-containing disulfides

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Structure of water incorporated in sulfobetaine polymer films as studied by ATR-FTIR

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Initial and follow-up results of the BiodivYsio phosphorylicholine coated stent for treatment of coronary artery disease

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Molecular simulation to characterize the adsorption behavior of a fibrinogen γ-chain fragment

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Mediation of biomaterial-cell interactions by adsorbed proteins: A review

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Neutrophil extracellular traps kill bacteria

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The zwitterion effect in high-conductivity polyelectrolyte materials

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Effect of water-soluble phospholipid polymers conjugated with papain on the enzymatic stability

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Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis

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Synthesis of hydrophilic cross-linker having phosphorylcholine-like linkage for improvement of hydrogel properties

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Structure of water in the vicinity of phospholipid analogue copolymers as studied by vibrational spectroscopy

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Antifouling blood purification membrane composed of cellulose acetate and phospholipid polymer

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Energy consumption and membrane replacement cost for seawater RO desalination plants

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Effect of membrane surface roughness on colloid-membrane DLVO interactions

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Enhanced solubility of paclitaxel using water-soluble and biocompatible 2-methacryloyloxyethyl phosphorylcholine polymers

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Kosmotropes form the basis of protein-resistant surfaces

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In vivo evaluation of a MPC polymer coated continuous flow left ventricular assist system

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Platelet adhesion onto segmented polyurethane surfaces modified by carboxybetaine

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Long-term stability of a coronary stent coating post implantation

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Synthesis and solution properties of zwitterionic polymers

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Hydrogen-bonded network structure of water in aqueous solution of sulfobetaine polymers

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Fluidity of bound hydration layers

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A nonthrombogenic gas-permeable membrane composed of a phospholipid polymer skin film adhered to a polyethylene porous membrane

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Preparation of blood-compatible hollow fibers from a polymer alloy composed of polysulfone and 2-methacryloyloxyethyl phosphorylcholine polymer

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Analysis of a phosphorylcholine-based polymer coating on a coronary stent pre- and post-implantation

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Stenting very small coronary narrowings (< 2 mm) using the biocompatible phosphorylcholine-coated coronary stent

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CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS (2002)

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The vascular prosthesis without pseudointima prepared by anti thrombogenic phospholipid polymer

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Grafting sulfobetaine monomer onto the segmented poly(ether-urethane) surface to improve hemocompatibility

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Preparation of cross-linked biocompatible poly(2-methacryloyloxyethyl phosphorylcholine) gel and its strange swelling behavior in water/ethanol mixture

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A novel phosphorylcholine-coated contact lens for extended wear use

SL Willis et al.

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Self-assembled monolayers that resist the adsorption of proteins and the adhesion of bacterial and mammalian cells

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A survey of structure-property relationships of surfaces that resist the adsorption of protein

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Facile synthesis of well-defined, biocompatible phosphorylcholine-based methacrylate copolymers via atom transfer radical polymerization at 20 °C

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Surface properties, fibrinogen adsorption, and cellular interactions of a novel phosphorylcholine-containing self-assembled monolayer on gold

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Zwitterionic SAMs that resist nonspecific adsorption of protein from aqueous buffer

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Riddle of biofilm resistance

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Crosslinkable coatings from phosphorylcholine-based polymers

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Protein adsorption to oligo(ethylene glycol) self-assembled monolayers: Experiments with fibrinogen, heparinized plasma, and serum

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Four years field experience with fouling resistant reverse osmosis membranes

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Raman spectroscopic study on the structure of water in aqueous polyelectrolyte solutions

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Characterization of protein adsorption at the phosphorylcholine incorporated polymer-water interface

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MACROMOLECULES (2000)

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Article Ecology

Comparative effects of temperature on suspension feeding and energy budgets of the pearl oysters Pinctada margaritifera and P-maxima

H Yukihira et al.

MARINE ECOLOGY PROGRESS SERIES (2000)

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Article Cardiac & Cardiovascular Systems

Biocompatibility of phosphorylcholine coated stents in normal porcine coronary arteries

DM Whelan et al.

HEART (2000)

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Article Engineering, Biomedical

Small diameter vascular prosthesis with a nonthrombogenic phospholipid polymer surface: Preliminary study of a new concept for functioning in the absence of pseudo- or neointima formation

T Yoneyama et al.

ARTIFICIAL ORGANS (2000)

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Article Polymer Science

Effects of polyelectrolyte complexation on the UCST of zwitterionic polymer

L Chen et al.

POLYMER (2000)

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Zwitterionic Biomaterials

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