Journal
CHEMICAL REVIEWS
Volume 122, Issue 23, Pages 17073-17154Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.2c00344
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Funding
- National Key Research and Development Program of China [2020YFE0204400, 2021YFC2100800]
- National Natural Science Foundation of China [22208240, 22175152, 52103188, 21621004, 21961132005, 22078238]
- Zhejiang Provincial Natural Science Foundation of China [LHDMZ22H300011]
- Huadong Medicine [LHDMZ22H300011]
- Fundamental Research Funds for the Central Universities [226-2022-00146]
- Open Funding Project of the National Key Laboratory of Biochemical Engineering
- Office of Naval Research [N0001420-1-2731]
- National Science Foundation [DMR 2002940, CBET 2103295, 1806138, 2107619]
- ACS Petroleum Research Fund [65277-ND7]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [2107619] Funding Source: National Science Foundation
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1806138] Funding Source: National Science Foundation
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This review provides a comprehensive overview of the fundamentals, properties, and biomedical applications of zwitterionic materials.
The term zwitterionic polymers refers to polymers that bear a pair of oppositely charged groups in their repeating units. When these oppositely charged groups are equally distributed at the molecular level, the molecules exhibit an overall neutral charge with a strong hydration effect via ionic solvation. The strong hydration effect constitutes the foundation of a series of exceptional properties of zwitterionic materials, including resistance to protein adsorption, lubrication at interfaces, promotion of protein stabilities, antifreezing in solutions, etc. As a result, zwitterionic materials have drawn great attention in biomedical and engineering applications in recent years. In this review, we give a comprehensive and panoramic overview of zwitterionic materials, covering the fundamentals of hydration and nonfouling behaviors, different types of zwitterionic surfaces and polymers, and their biomedical applications.
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