4.7 Article

In-situ NO release and conversion for highly efficient synergistic gas therapy and phototherapy

Journal

CHEMICAL ENGINEERING JOURNAL
Volume 444, Issue -, Pages -

Publisher

ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2022.136512

Keywords

Carbon nanodots; NO therapy; Photodynamic therapy; Photothermal therapy; NIR-II

Funding

  1. National Natural Science Foundation of China [21571045, 81101085]
  2. Natural Science Foundation of Heilongjiang Province of China [TD2020B001, LH2020H067]
  3. Excellent Scientific Research Team Project of Harbin Normal University [XKYT202001]
  4. Basic Scientific Research Pro-jects of Department of Education of Heilongjiang [2020-KYYWF-0353]
  5. Heilongjiang Postdoctoral Program [LBH-Q16173]

Ask authors/readers for more resources

In this paper, simple nitrated carbon dots (CDs-NO) were synthesized as a nanoparticle that combines gas therapy and phototherapy therapy. Under near-infrared irradiation, the generated ROS combines with NO to form highly cytotoxic radicals, effectively inhibiting cancer cells. The synergistic NO therapy and photothermal/dynamic therapy not only have a significant therapeutic effect on tumor-bearing mice but also efficiently inhibit metastasis.
In this paper, simple nitrated carbon dots (CDs-NO) were prepared as NO donor as well as photosensitizer to integrate gas therapy and phototherapy therapy into one nanoparticle. Firstly, carbon nanodots (CDs) were synthesized by using methylene blue (MB) as carbon source via hydrothermal strategy with H2SO4 as oxidization and dehydration (carbonization) agent. On account of the aromas property and the present heteroatom of MB, as synthesized CDs possess great NIR-II harvest and photothermal conversion ability (29.7 %). To take advantage of the abundant incoming -OH, nitration treatment is performed to obtain CDs-NO, which produces NO gas under the stimuli of glutathione (GSH) and hyperpyrexia. The consumption of GSH also benefits to the elevation of intracellular oxidative stress. Under NIR-II (1064 nm) irradiation, the generated ROS would combine with NO in situ to form ONOO- radicals, which possess the higher cytotoxicity to cancer cells. The short distance between ROS and NO makes sure the quick conversion and high utilization of NO. The synergistic NO therapy and photothermal/dynamic therapy not only reveals remarkable therapeutic effect for tumor bearing mice but also arouses immune response for metastasis inhibition efficiently.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available