Journal
CHANNELS
Volume 16, Issue 1, Pages 198-215Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19336950.2022.2103234
Keywords
VGSCs; VGCCs; natural products; plants; fungi; pain
Categories
Funding
- National Institutes of Health [NS098772, NS120663, DA042852]
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This review synthesizes information on approximately 30 compounds derived from natural sources such as plants and fungi, and delineates their effects on VGSCs and VGCCs in human diseases, particularly in pain. Some natural products have entered clinical trials, while others are under investigation for their action mechanisms.
Voltage-gated sodium and calcium channels (VGSCs and VGCCs) play an important role in the modulation of physiologically relevant processes in excitable cells that range from action potential generation to neurotransmission. Once their expression and/or function is altered in disease, specific pharmacological approaches become necessary to mitigate the negative consequences of such dysregulation. Several classes of small molecules have been developed with demonstrated effectiveness on VGSCs and VGCCs; however, off-target effects have also been described, limiting their use and spurring efforts to find more specific and safer molecules to target these channels. There are a great number of plants and herbal preparations that have been empirically used for the treatment of diseases in which VGSCs and VGCCs are involved. Some of these natural products have progressed to clinical trials, while others are under investigation for their action mechanisms on signaling pathways, including channels. In this review, we synthesize information from similar to 30 compounds derived from natural sources like plants and fungi and delineate their effects on VGSCs and VGCCs in human disease, particularly pain. [GRAPHICS] .
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