Journal
CERAMICS INTERNATIONAL
Volume 49, Issue 4, Pages 5613-5620Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2022.10.163
Keywords
Composite; Green synthesis; Nanoparticles; Anticancer
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This study proposes a green synthesis approach for the production of zinc oxide/silver nanoparticles using plant extracts. The nanoparticles were characterized using various techniques and it was found that those synthesized with moringa oleifera extracts had a narrow size distribution. The research also demonstrated the strong anticancer activity of the zinc oxide/silver nanoparticles, suggesting their potential use in biomedicine.
This study proposes a simple, effective, and environmentally friendly approach for the synthesis of zinc oxide/ silver nanoparticles (ZnO/Ag NPs) using three different plant extracts. The plants used in this study were moringa oleifera (MO), mentha piperita (MP), and citrus lemon (CL). Characterizations of ZnO/Ag NPs were done using ultraviolet-visible spectroscopy (UV vis), X-ray diffraction (XRD), field emission scanning electron microscope (FESEM) along with energy dispersive spectroscopy (EDX), and fourier transform infrared spec-troscopy (FTIR). In accordance with size distribution findings, ZnO/Ag NPs synthesized with MO have a narrow size distribution, with the average particle size being 119 +/- 36 nm. Among these three reducing agent MO act as the best reducing agent. Moreover, the anticancer activity of silver nanoparticles (Ag NPs), zinc oxide nano -particles (ZnO NPs) and ZnO/Ag NPs synthesized with MO were demonstrated in human cervical cancer cells (HeLA). The results revealed that ZnO/Ag NPs demonstrate in vitro cell viability of 72%, 81%, and 84% using 2.5, 5, and 10 mu gml-1of ZnO/Ag NPs for 24 h. While Ag NPs and ZnO NPs prepared with MO showed 50% and 60% cell viability using 2.5 mu gml-1concentration for 24 h. This showed that the ZnO/Ag NPs act as a strong anticancer agent compared to Ag NPs and ZnO NPs. Overall, this research proposes a green synthesis approach for ZnO/Ag NPs with a wide range of potential uses, particularly in biomedicine.
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