4.7 Article

Misfolded protein oligomers induce an increase of intracellular Ca2+ causing an escalation of reactive oxidative species

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors

Giulia Fani et al.

Summary: Alzheimer's disease, the most common form of dementia, is characterized by the toxicity mechanism of Aβ oligomers through perturbing the mechanical properties of lipid membranes sensed by NMDA and AMPA receptors.

ACS CHEMICAL NEUROSCIENCE (2021)

Review Biochemistry & Molecular Biology

Calcium Dyshomeostasis in Alzheimer's Disease Pathogenesis

Roberta Cascella et al.

Summary: Alzheimer's disease is a common age-related neurodegenerative disorder characterized by amyloid beta-protein deposition and neurofibrillary tangles, leading to cognitive decline and dementia. Despite extensive research, the exact mechanisms underlying AD remain unknown and effective treatment is not available.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Oxidative stress and the amyloid beta peptide in Alzheimer's disease

C. Cheignon et al.

REDOX BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Calcium signaling in Alzheimer's disease & therapies

Benjamin Chun-Kit Tong et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)

Article Neurosciences

Soluble Oligomers Require a Ganglioside to Trigger Neuronal Calcium Overload

Roberta Cascella et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Review Neurosciences

Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease

Eric Tonnies et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Review Neurosciences

Molecular Pathogenesis of Alzheimer's Disease: An Update

Alfredo Sanabria-Castro et al.

ANNALS OF NEUROSCIENCES (2017)

Article Integrative & Complementary Medicine

Ginsenoside Rg1 inhibits high-voltage-activated calcium channel currents in hippocampal neurons of beta-amyloid peptide-exposed rat brain slices

Qian-kun Quan et al.

Chinese Journal of Integrative Medicine (2016)

Review Medicine, Research & Experimental

The amyloid hypothesis of Alzheimer's disease at 25years

Dennis J. Selkoe et al.

EMBO MOLECULAR MEDICINE (2016)

Article Agriculture, Multidisciplinary

Impact of Phosphatidylethanolamine on the Antioxidant Activity of α-Tocopherol and Trolox in Bulk Oil

Leqi Cui et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2015)

Review Biochemistry & Molecular Biology

Calcium and ROS: A mutual interplay

Agnes Goerlach et al.

REDOX BIOLOGY (2015)

Review Pharmacology & Pharmacy

Calcium channelopathies and Alzheimer's disease: Insight into therapeutic success and failures

Shreaya Chakroborty et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2014)

Review Neurosciences

Models of β-amyloid induced Tau-pathology: the long and folded road to understand the mechanism

Ilie-Cosmin Stancu et al.

MOLECULAR NEURODEGENERATION (2014)

Article Geriatrics & Gerontology

Nature of the neurotoxic membrane actions of amyloid-β on hippocampal neurons in Alzheimer's disease

Fernando J. Sepulveda et al.

NEUROBIOLOGY OF AGING (2014)

Article Biochemistry & Molecular Biology

Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro

Roberta Cascella et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)

Article Geriatrics & Gerontology

Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N

Francesca Tatini et al.

NEUROBIOLOGY OF AGING (2013)

Review Cell Biology

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

Yan Zhao et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)

Article Biochemistry & Molecular Biology

Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

Kristina Leuner et al.

ANTIOXIDANTS & REDOX SIGNALING (2012)

Review Neurosciences

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

Iryna Benilova et al.

NATURE NEUROSCIENCE (2012)

Article Cell Biology

Amyloid β peptide oligomers directly activate NMDA receptors

Laura Texido et al.

CELL CALCIUM (2011)

Article Cell Biology

A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells

Mariagioia Zampagni et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2011)

Article Genetics & Heredity

Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane

Mariagioia Zampagni et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2010)

Article Biochemistry & Molecular Biology

N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers

Helena Decker et al.

JOURNAL OF NEUROCHEMISTRY (2010)

Article Biochemistry & Molecular Biology

A causative link between the structure of aberrant protein oligomers and their toxicity

Silvia Campioni et al.

NATURE CHEMICAL BIOLOGY (2010)

Review Neurosciences

Oxidative stress in Alzheimer disease: A possibility for prevention

David J. Bonda et al.

NEUROPHARMACOLOGY (2010)

Article Multidisciplinary Sciences

Small molecule blockers of the Alzheimer Aβ calcium channel potently protect neurons from Aβ cytotoxicity

Juan Carlos Diaz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Cell Biology

Oxidative stress in Alzheimer disease

Alejandro Gella et al.

CELL ADHESION & MIGRATION (2009)

Review Cell Biology

Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide

Christian Haass et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

A Demuro et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Biochemistry & Molecular Biology

Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases

KS Montine et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2004)

Article Biochemistry & Molecular Biology

The inhibitory and facilitatory actions of amyloid-β peptides on nicotinic ACh receptors and AMPA receptors

H Tozaki et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

Article Biochemistry & Molecular Biology

Vaccination with soluble Aβ oligomers generates toxicity-neutralizing antibodies

MP Lambert et al.

JOURNAL OF NEUROCHEMISTRY (2001)

Article Geriatrics & Gerontology

Oxidative stress and protein aggregation during biological aging

TC Squier

EXPERIMENTAL GERONTOLOGY (2001)

Review Biochemistry & Molecular Biology

Protein oxidation and age-dependent alterations in calcium homeostasis

TC Squier et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2000)