Journal
CELL HOST & MICROBE
Volume 30, Issue 10, Pages 1464-+Publisher
CELL PRESS
DOI: 10.1016/j.chom.2022.08.013
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Funding
- Dutch Heart Foundation
- Netherlands Organisation for Health Research and Development (ZonMw)
- European Union (FP-7)
- European Fund for the Integration of non-EU immigrants (EIF)
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [813781]
- ZonMw VICI grant 2020 [09150182010020]
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This study conducted a large-scale fecal microbiome genome-wide association study on a multiethnic cohort, revealing ethnic-specific associations between host genomes and gut microbiota. The study also sheds light on the potential effects of gut microbes on cardiometabolic health factors.
Previous studies in mainly European populations have reported that the gut microbiome composition is associated with the human genome. However, the genotype-microbiome interaction in different ethnicities is largely unknown. We performed a large fecal microbiome genome-wide association study of a single multiethnic cohort, the Healthy Life in an Urban Setting (HELIUS) cohort (N = 4,117). Mendelian randomization was performed using the multiethnic Pan-UK Biobank (N = 460,000) to dissect potential causality. We identified ethnicity-specific associations between host genomes and gut microbiota. Certain microbes were associated with genotype in multiple ethnicities. Several of the microbe-associated loci were found to be related to immune functions, interact with glutamate and the mucus layer, or be expressed in the gut or brain. Additionally, we found that gut microbes potentially influence cardiometabolic health factors such as BMI, cholesterol, and blood pressure. This provides insight into the relationship of ethnicity and gut microbiota and into the possible causal effects of gut microbes on cardiometabolic traits.
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